Publikationen im NUM
Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.
A. Wulff,
C. Baier,
M. Marschollek and
et al,
"SmICS: Eine smarte Lösung zur automatisierten Ausbruchserkennung im Krankenhaus",
Gesundhyte,
vol. 14,
2021.
| Datei: |  https://www.systembiologie.de/lw_resource/datapool/systemfiles/elements/files/D344CA9772B73013E0537E695E8653F9/live/document/PTJ-009_gesundhyte_14_2021_dt_WEB-ISSN_2702-2552_211215_WEB.pdf |
C. Schug,
E. Morawa,
F. Geiser,
N. Hiebel,
P. Beschoner,
L. Jerg-Bretzke,
C. Albus,
K. Weidner,
S. Steudte-Schmiedgen,
A. Borho,
M. Lieb and
Y. Erim,
"Social Support and Optimism as Protective Factors for Mental Health among 7765 Healthcare Workers in Germany during the COVID-19 Pandemic: Results of the VOICE Study",
International Journal of Environmental Research and Public Health,
vol. 18,
no. 7,
2021.
| DOI: | 10.3390/ijerph18073827 |
| Datei: | https://doi.org/10.3390/ijerph18073827 |
N. Dragano,
J. Hoebel,
B. Wachtler,
M. Diercke,
T. Lunau and
M. Wahrendorf,
"Soziale Ungleichheit in der regionalen Ausbreitung von SARS-CoV-2",
Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz,
vol. 64,
pp. 1116—1124,
2021.
| DOI: | 10.1007/s00103-021-03387-w |
R. Rubio-Acero,
J. Beyerl,
M. Muenchhoff,
M. S. Roth,
N. Castelletti,
I. Paunovic,
K. Radon,
B. Springer,
C. Nagel,
B. Boehm,
M. M. Böhmer,
A. Graf,
H. Blum,
S. Krebs,
O. T. Keppler,
A. Osterman,
Z. N. Khan,
M. Hoelscher and
A. Wieser,
"Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience",
The Science of the total environment,
vol. 797,
pp. 149031,
2021.
Abstract:
Wastewater-based epidemiology (WBE) is a tool now increasingly proposed to monitor the SARS-CoV-2 burden in populations without the need for individual mass testing. It is especially interesting in metropolitan areas where spread can be very fast, and proper sewage systems are available for sampling with short flow times and thus little decay of the virus. We started in March 2020 to set up a once-a-week qualified spot sampling protocol in six different locations in Munich carefully chosen to contain primarily wastewater of permanent residential areas, rather than industry or hospitals. We used RT-PCR and sequencing to track the spread of SARS-CoV-2 in the Munich population with temporo-spatial resolution. The study became fully operational in mid-April 2020 and has been tracking SARS-CoV-2 RNA load weekly for one year. Sequencing of the isolated viral RNA was performed to obtain information about the presence and abundance of variants of concern in the Munich area over time. We demonstrate that the evolution of SARS-CoV-2 RNA loads (between \textless7.5 and 3874/ml) in these different areas within Munich correlates well with official seven day incidence notification data (between 0.0 and 327 per 100,000) obtained from the authorities within the respective region. Wastewater viral loads predicted the dynamic of SARS-CoV-2 local incidence about 3 weeks in advance of data based on respiratory swab analyses. Aligning with multiple different point-mutations characteristic for certain variants of concern, we could demonstrate the gradual increase of variant of concern B.1.1.7 in the Munich population beginning in January 2021, weeks before it became apparent in sequencing results of swabs samples taken from patients living in Munich. Overall, the study highlights the potential of WBE to monitor the SARS-CoV-2 pandemic, including the introduction of variants of concern in a local population.
| DOI: | 10.1016/j.scitotenv.2021.149031 |
Abstract:
Wastewater-based epidemiology (WBE) is a tool now increasingly proposed to monitor the SARS-CoV-2 burden in populations without the need for individual mass testing. It is especially interesting in metropolitan areas where spread can be very fast, and proper sewage systems are available for sampling with short flow times and thus little decay of the virus. We started in March 2020 to set up a once-a-week qualified spot sampling protocol in six different locations in Munich carefully chosen to contain primarily wastewater of permanent residential areas, rather than industry or hospitals. We used RT-PCR and sequencing to track the spread of SARS-CoV-2 in the Munich population with temporo-spatial resolution. The study became fully operational in mid-April 2020 and has been tracking SARS-CoV-2 RNA load weekly for one year. Sequencing of the isolated viral RNA was performed to obtain information about the presence and abundance of variants of concern in the Munich area over time. We demonstrate that the evolution of SARS-CoV-2 RNA loads (between \textless7.5 and 3874/ml) in these different areas within Munich correlates well with official seven day incidence notification data (between 0.0 and 327 per 100,000) obtained from the authorities within the respective region. Wastewater viral loads predicted the dynamic of SARS-CoV-2 local incidence about 3 weeks in advance of data based on respiratory swab analyses. Aligning with multiple different point-mutations characteristic for certain variants of concern, we could demonstrate the gradual increase of variant of concern B.1.1.7 in the Munich population beginning in January 2021, weeks before it became apparent in sequencing results of swabs samples taken from patients living in Munich. Overall, the study highlights the potential of WBE to monitor the SARS-CoV-2 pandemic, including the introduction of variants of concern in a local population.
R. Rubio-Acero,
J. Beyerl,
M. Muenchhoff and
et al,
"Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich: One year of experience",
Sci Total Environ,
vol. 797,
2021.
| DOI: | 10.1016/j.scitotenv.2021.149031 |
S. Einhauser,
D. Peterhoff,
H. H. Niller and
et al,
"Spectrum bias and individual strengths of SARS-CoV-2 serological tests—A population-based evaluation",
Diagnostics,
vol. 11,
no. 10,
2021.
| DOI: | 10.3390/diagnostics11101843 |
| Datei: | https://doi.org/10.3390/diagnostics11101843 |
D. Alvarez-Fischer,
M. Borsche,
A. Balck and
et al,
"Spreading of SARS-CoV-2 Among Adult Asylum Seekers in Refugee Shelters in Germany",
Lancet,
2021.
| DOI: | 10.2139/ssrn.3889435 |
M. Geraedts,
M. Eberlein-Gonska,
R. Hecker,
K. Schneider,
I. Schroeder-Printzen and
M. Zeuner,
"Stationäre Versorgung: Empfehlungen für ein künftiges Pandemiemanagement",
Dtsch Arztebl International,
vol. 118,
no. 19—20,
pp. A-991,
2021.
C. R. Torres Reyes,
E. Steinmann,
N. Timmesfeld and
et al,
"Students in Dormitories were not major drivers of the pandemic during winter term 2020/2021: A cohort study with RT-PCR and antibody surveillance in a German university city",
COVID,
vol. 1,
no. 1,
2021.
| DOI: | 10.3390/covid1010029 |
S. Warnat-Herresthal and
et al,
"Swarm Learning for decentralized and confidential clinical machine learning",
Nature,
2021.
| DOI: | 10.1038/s41586-021-03583-3 |
T. Hempel and
et al,
"Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties",
Chemical Science,
vol. 12,
pp. 12600–12609,
2021.
| DOI: | 10.1039/D1SC01494C |
C. Wagner,
M. Griesel,
A. Mikolajewska,
A. Mueller,
M. Nothacker,
K. Kley,
M. Metzendorf,
A. Fischer,
M. Kopp,
M. Stegemann,
N. Skoetz and
F. Fichtner,
"Systemic corticosteroids for the treatment of COVID-19",
Cochrane Database of Systematic Reviews,
vol. 2021,
pp. CD014963,
2021.
| DOI: | 10.1002/14651858.CD014963 |
M. O'Hare,
D. Amarnani,
H. A. B. Whitmore,
M. An,
C. Marino,
L. Ramos,
S. Delgado-Tirado,
X. Hu,
N. Chmielewska,
A. Chandrahas and
others,
"Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators",
Am J Pathol,
vol. 191,
no. 7,
pp. 1193-1208,
2021.
| DOI: | 10.1016/j.ajpath.2021.04.006 |
M. Baldinger,
A. Heinrich,
T. Adams,
E. Martens,
M. Dommasch,
A. Muller,
A. Siegmann,
G. Schmidt,
O. Amft and
K. V. Laerhoven,
"TELECOVID: Remote Vital Signs Monitoring of COVID-19 Risk Patients in Home Isolation With an In-Ear Wearable",
IEEE Pervasive Computing,
vol. 20,
no. 2,
pp. 58—62,
2021.
| DOI: | 10.1109/MPRV.2021.3066825 |
G. Nouailles,
E. Wyler,
P. Pennitz,
D. Postmus,
D. Vladimirova,
J. Kazmierski,
F. Pott,
K. Dietert,
M. Muelleder,
V. Farztdinov,
B. Obermayer,
S. Andreotti,
B. Sawitzki,
C. Drosten,
L. E. Sander,
N. Suttorp,
M. Ralser,
D. Beule,
A. Gruber,
C. Goffinet,
M. Landthaler,
J. Trimpert,
M. Witzenrath,
S. Wienhold and
T. Hoefler,
"Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19",
Nat Commun.2021;12(1):4869,
2021.
G. Nouailles,
E. Wyler,
P. Pennitz,
D. Postmus,
D. Vladimirova and
e. a. Kazmierski,
"Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19",
Nat Commun,
vol. 12,
pp. 4869,
2021.
| DOI: | 10.1038/s41467-021-25030-7 |
G. Nouailles,
E. Wyler,
P. Pennitz,
D. Postmus,
D. Vladimirova,
J. Kazmierski,
F. Pott,
K. Dietert,
M. Muelleder,
V. Farztdinov and
others,
"Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19",
Nat Commun,
vol. 12,
no. 1,
pp. 4869,
2021.
| DOI: | 10.1038/s41467-021-25030-7 |
L. Krüger,
M. Gaeddert,
F. Tobian and
others,
"The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2—Evaluation of the accuracy and ease-of-use",
PLOS ONE,
vol. 16,
no. 5,
2021.
| DOI: | 10.1371/journal.pone.0247918 |
| Datei: | https://doi.org/10.1371/journal.pone.0247918 |
M. Witzenrath and
W. Kuebler,
"The CypA-netics of Ventilator-induced Lung Injury",
Am J Respir Crit Care Med,
vol. 204,
no. 4,
pp. 385—387,
2021.
| DOI: | 10.1164/rccm.202104-0919ED |
M. Witzenrath and
W. Kuebler,
"The CypA-netics of Ventilator-induced Lung Injury. Am J Respir Crit Care Med",
204(4):385-387,
2021.
C. Ramirez Alvarez,
C. Kee,
A. K. Sharma,
L. Thomas,
F. I. Schmidt and
e. a. Stanifer,
"The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated with disease severity",
PLOS Pathogens,
vol. 17,
no. 5,
pp. e1009687,
2021.
| DOI: | 10.1371/journal.ppat.1009687 |
F. Hornung,
J. Rogal,
P. Loskill,
B. Löffler and
S. Deinhardt-Emmer,
"The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections",
Int J Mol Sci,
vol. 22,
2021.
V. Clemens,
P. Beschoner,
M. Jarczok,
K. Weimer,
M. Kempf,
E. Morawa,
F. Geiser,
C. Albus,
S. Steudte-Schmiedgen,
H. Gündel,
J. Fegert and
L. Jerg-Bretzke,
"The mediating role of COVID-19-related burden in the association between adverse childhood experiences and emotional exhaustion: Results of the egePan–VOICE study",
European Journal of Psychotraumatology,
vol. 12,
no. 1,
pp. 1976441,
2021.
| DOI: | 10.1080/20008198.2021.1976441 |
M. Hoffmann and
et al,
"The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic",
Cell,
2021.
| DOI: | 10.1016/j.cell.2021.12.032 |
J. Wachinger,
I. D. Olaru,
S. Horner and
et al,
"The potential of SARS-CoV-2 antigen-detection tests in the screening of asymptomatic persons",
Clin Microbiol Infect,
vol. 27,
no. 11,
2021.
| DOI: | 10.1016/j.cmi.2021.07.020 |
| Datei: | https://doi.org/10.1016/j.cmi.2021.07.020 |
I. Panchyrz,
S. Pohl,
J. Hoffmann,
C. Gatermann,
F. Walther,
L. Harst,
H. Held,
C. Kleber,
M. Albrecht and
J. Schmitt,
"The role of university hospitals in regional health care management for coping with the COVID-19 pandemic",
Zeitschrift Für Evidenz, Fortbildung Und Qualität Im Gesundheitswesen,
vol. 167,
pp. 68—77,
2021.
| DOI: | 10.1016/j.zefq.2021.09.004 |
J. Wenzel,
J. Lampe,
H. Müller-Fielitz and
et al,
"The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells",
Nat Neurosci,
vol. 24,
no. 11,
pp. 1522-1533,
2021.
| DOI: | 10.1038/s41593-021-00926-1 |
K. Kitazawa,
S. Deinhardt-Emmer,
T. Inomata,
S. Deshpande and
C. Sotozono,
"The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies",
Cells,
vol. 10,
2021.
M. R. Muzoora and
et al,
"Towards FAIR Patient Reported Outcome: Application of the Interoperability Principle for Mobile Pandemic Apps",
Stud Health Technol Inform,
vol. 287,
pp. 85—86,
2021.
| DOI: | 10.3233/SHTI210315 |
E. Wyler,
K. Mosbauer,
V. Franke,
A. Diag,
L. T. Gottula and
e. a. Arsie,
"Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy",
iScience,
vol. 24,
pp. 102151,
2021.
| DOI: | 10.1016/j.isci.2021.102151 |
I. Backhaus,
D. Hermsen,
J. Timm,
F. Boege,
N. Lübke,
K. Göbels,
D. Lieth and
N. Dragano,
"Under-ascertainment of COVID-19 cases among first responders: a seroepidemiological study",
Occupational Medicine,
pp. kqab164,
2021.
| DOI: | 10.1093/occmed/kqab164 |
S. Schuster,
J. Lisack,
I. Subota,
H. Zimmermann,
C. Reuter and
e. a. Mueller,
"Unexpected plasticity in the life cycle of Trypanosoma brucei",
Elife,
vol. 10,
2021.
| DOI: | 10.7554/eLife.62090 |
C. Klinger,
J. Burns,
A. Movsisyan,
R. Biallas,
S. L. Norris,
J. E. Rabe,
J. M. Stratil,
S. Voss,
K. Wabnitz,
E. A. Rehfuess and
B. Verboom,
"Unintended health and societal consequences of international travel measures during the COVID-19 pandemic: A scoping review",
J Travel Med,
2021.
| DOI: | 10.1093/jtm/taab123 |
M. Witkowski,
C. Tizian,
M. Ferreira-Gomes,
D. Niemeyer,
T. C. Jones and
e. a. Heinrich,
"Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells",
Nature,
2021.
| DOI: | 10.1038/s41586-021-03859-9 |
M. Witkowski,
C. Tizian,
M. Ferreira-Gomes and
et al,
"Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells",
Nature,
vol. 600,
no. 7888,
pp. 295-301,
2021.
| DOI: | 10.1038/s41586-021-04142-6 |
M. Witkowski and
et al,
"Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells",
Nature,
2021.
| DOI: | 10.1038/s41586-021-04142-6 |
[German]
S. Berezowska,
P. Boor,
D. Jonigk and
V. Tischler,
"Update on thoracic pathology 2021-report of the working group thoracic pathology of the German Society of Pathology",
Pathologe,
pp. 1-4,
2021.
| DOI: | 10.1007/s00292-021-00991-0 |
T. S. Boender,
W. Cai,
M. Schranz and
others,
"Using routine emergency department data for syndromic surveillance of acute respiratory illness before and during the COVID-19 pandemic in Germany, week 10-2017 and 10-2021",
medRxiv,
Aug.
2021.
| DOI: | 10.1101/2021.08.19.21262303 |
O. Gross,
O. Moerer,
T. Rauen and
et al,
"Validation of a Prospective Urinalysis-Based Prediction Model for ICU Resources and Outcome of COVID-19 Disease: A Multicenter Cohort Study",
J Clin Med,
vol. 10,
no. 14,
2021.
| DOI: | 10.3390/jcm10143049 |
L. Nicolai,
A. Leunig,
S. Brambs,
R. Kaiser,
M. Joppich,
M. Hoffknecht,
C. Gold,
A. Engel,
V. Polewka,
M. Muenchhoff and
others,
"Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia",
J Thromb Haemost,
vol. 19,
no. 2,
pp. 574-581,
2021.
| DOI: | 10.1111/jth.15179 |
K. Roedl,
S. Heidenreich,
S. Pfefferle,
D. Jarczak,
T. T. Urbanowicz,
D. Nörz,
M. Aepfelbacher,
N. Kröger,
S. Kluge,
M. Lütgehetmann,
M. Christopeit and
D. Wichmann,
"Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19",
Am J Respir Crit Care Med,
vol. 203,
no. 2,
pp. 242-245,
2021.
J. K. Stroehlein,
J. Wallqvist,
C. Iannizzi,
A. Mikolajewska,
M. Metzendorf,
C. Benstoem,
P. Meybohm,
M. Becker,
N. Skoetz,
M. Stegemann and
V. Piechotta,
"Vitamin D supplementation for the treatment of COVID-19: a living systematic review",
Cochrane Database of Systematic Reviews,
vol. 2021,
pp. CD015043,
2021.
| DOI: | 10.1002/14651858.CD015043 |
S. Weigang,
J. Fuchs,
G. Zimmer and
et al,
"Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants",
Nat Commun,
vol. 12,
no. 1,
2021.
| DOI: | 10.1038/s41467-021-26602-3 |
| Datei: | https://doi.org/10.1038/s41467-021-26602-3 |
D. Eggers,
"Best practice models for nursing care in the COVID-19-pandemic: a web-based survey. Joint Scientific Summer Conference DGP/EANS. Lessons learned from the pandemic in different nursing settings. 02.07.2021. Vortrag.",
2021.
M. Metzendorf,
J. Hildebrandt,
T. Jakob and
R. M. Featherstone,
"Das Cochrane COVID-19 Studienregister – eine studienbasierte, strukturierte Datenbank zur effizienten Identifizierung wissenschaftlicher Evidenz"
in Vortrag. 22. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin,
2021.
M. Winter and
et al,
"Exploring the Usability of the German COVID-19 Contact Tracing App in a Combined Eye Tracking and Retrospective Think Aloud Study"
in 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society,
2021,
pp. 2215—2221.
| DOI: | 10.1109/EMBC48546.2021.9630667 |
M. Lowin and
D. Kellner,
"From Twitter to COVID-19: Using NLP to Predict COVID-19 Infections"
in PACIS 2021 Proceedings,
2021.
F. Beierle and
et al,
"Public Perception of the German COVID-19 Contact-Tracing App Corona-Warn-App"
in 2021 IEEE 34th International Symposium on Computer-Based Medical Systems,
2021,
pp. 342—347.
| DOI: | 10.1109/CBMS52030.2021.00120 |
G. Anton,
A. Kuehn-Steven,
M. K. Taucher,
I. Bernemann and
T. Illig,
"Quality management in times of COVID-19: Remote audits as tool to assess sample quality for NAPKON"
in European Biobank Week 2021,
2021.
V. Authors,
"RACOON - die Zukunft durch vernetzte Intelligenz I = Die Plattform der deutschen Radiologie im Netzwerk Universitätsmedizin"
in Deutscher Röntgenkongress,
2021.