Publikationen im NUM

Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.

C. Thibeault and et al, "Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study", Infection, 2021.
DOI:10.1007/s15010-021-01594-w
C. Thibeault, B. Mühlemann, E. Helbig, M. Mittermaier, T. Lingscheid, P. Tober-Lau, L. Meyer-Arndt, L. Meiners, P. Stubbemann, S. Haenel and D. Stahl, "Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study", Infection, vol. 49, no. 4, pp. 703—714, 2021.
DOI:10.1007/s15010-021-01594-w
A. Mikolajewska, A. Fischer, V. Piechotta, A. Mueller, M. Metzendorf, M. Becker, E. Dorando, R. Pacheco, A. L. C. Martimbianco, R. Riera, N. Skoetz and M. Stegemann, "Colchicine for the treatment of COVID‐19", Cochrane Database of Systematic Reviews, vol. 2021, pp. CD015045, 2021.
DOI:10.1002/14651858.CD015045
M. Ochs, S. Timm, S. Elezkurtaj, D. Horst, J. Meinhardt and e. a. Heppner, "Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient", Eur Respir J, vol. 57, 2021.
DOI:10.1183/13993003.02311-2020
K. Herbst, M. Meurer, D. Kirrmaier and D. Stahl, "Colorimetric RT-LAMP and LAMP-sequencing for Detecting SARS-CoV-2 RNA in Clinical Samples", BIO-Protocols, vol. 11, no. 6, 2021.
DOI:10.21769/BioProtoc.3964
Datei:https://doi.org/10.21769/BioProtoc.3964
L. Brunotte, S. Zheng, A. Mecate-Zambrano, J. Tang, S. Ludwig and e. a. Rescher, "Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro", Pharmaceutics, vol. 13, 2021.
A. Müller, F. Engler, D. Schütze, P. Nohl-Deryk and C. Güthlin, "Communication experience by secure instant messaging during the Covid-19 pandemic for general practitioners and public health workers – a qualitative analysis", Doc21dkvf051, 2021.
DOI:10.3205/21dkvf051
A. Osterman, M. Iglhaut, A. Lehner and et al, "Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern", Med Microbiol Immunol, vol. 210, 2021.
DOI:10.1007/s00430-021-00719-0
A. Osterman, M. Iglhaut, A. Lehner, P. Späth, M. Stern, H. Autenrieth, M. Muenchhoff, A. Graf, S. Krebs, H. Blum, A. Baiker, N. Grzimek-Koschewa, U. Protzer, L. Kaderali, H. Baldauf and O. Keppler, "Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern", Medical microbiology and immunology, vol. 210, no. 5-6, pp. 263—275, 2021.
DOI:10.1007/s00430-021-00719-0
A. Osterman, M. Iglhaut, A. Lehner, P. Spaeth, M. Stern, H. Autenrieth, M. Muenchhoff, A. Graf, S. Krebs, H. Blum, A. Baiker, N. Grzimek-Koschewa, U. Protzer, L. Kaderali, H. Baldauf and O. T. Keppler, "Comparison of four commercial, automated antigen tests to detect SARS-CoV-2 variants of concern", Medical Microbiology and Immunology, 2021.
DOI:10.1007/s00430-021-00719-0
Datei:https://doi.org/10.1007/s00430-021-00719-0
P. Georg and et al, "Complement activation induces excessive T cell cytotoxicity in severe COVID-19", Cell, 2021.
DOI:10.1016/j.cell.2021.12.040
P. Georg, R. Astaburuaga-García, L. Bonaguro and et al, "Complement activation induces excessive T cell cytotoxicity in severe COVID-19", Cell, 2021.
DOI:10.1016/j.cell.2021.12.040
B. Föh, M. Borsche, A. Balck and et al, "Complications of nasal and pharyngeal swabs – a relevant challenge of the COVID-19 pandemic?", Eur Respir J, 2021.
DOI:10.1183/13993003.04004-2020
N. Bailis, M. Lerche, H. J. Meyer, A. Wienke and A. Surov, "Contrast reflux into the inferior vena cava on computer tomographic pulmonary angiography is a predictor of 24-hour and 30-day mortality in patients with acute pulmonary embolism", Acta radiologica (Stockholm, Sweden : 1987), vol. 62, no. 1, pp. 34-41, Jan. 2021.
DOI:10.1177/0284185120912506
Datei:https://pubmed.ncbi.nlm.nih.gov/32241170/

Abstract:
Acute pulmonary embolism (PE) is a common disease with a high mortality. Computed tomographic pulmonary angiography (CTPA) represents the current gold standard for the evaluation of patients with suspected PE. To search possible CTPA predictors of 24-h and 30-day mortality in PE. Overall, 224 patients with PE (46.4% women, mean age 64.7 ± 16.7 years) were acquired. CTPA was performed on a multi-slice CT scanner. The following radiological parameters were estimated: thrombotic obstruction index; diameter of the pulmonary trunk (mm); short axis ratio of right ventricle/left ventricle; diameter of the azygos vein (mm); diameter of the superior and inferior vena cava (mm); and reflux of contrast medium into the inferior vena cava (IVC). Patients who died within the first 24 h after admission (n = 32, 14.3%) showed a reflux grade 3 into IVC more often than survivors (odds ratio [OR] 7.6, 95% confidence interval [CI] 3.3-17.7; P < 0.001). Other relevant CTPA parameters were diameter of IVC (OR 1.1, 95% CI 1.01-1.21; P = 0.034) and diameter of the pulmonary trunk (OR 0.91, 95% CI 0.82-1.01, P = 0.074), whereas the Mastora score showed nearly no influence (OR 1.01, 95% CI 0.99-1.02, P = 0.406). Furthermore, 61 (27.2%) patients died within the first 30 days after admission. These patients showed a reflux grade 3 into IVC more often than survivors (OR 3.4, 95% CI 1.7-7.0; P = 0.001). Other CTPA parameters, such as diameter of IVC (OR 1.04, 95% CI 0.97-1.12; P = 0.277) and diameter of the pulmonary trunk (OR 0.96, 95% CI 0.89-1.04; P = 0.291), seem to have no relevant influence, whereas Mastora score did (OR 0.99, 95% CI 0.976-0.999, P = 0.045). Subhepatic contrast reflux into IVC is a strong predictor of 24-h and 30-day mortality in patients with acute PE.
V. Piechotta, C. Iannizzi, K. L. Chai, S. J. Valk, C. Kimber, E. Dorando, I. Monsef, E. M. Wood, A. A. Lamikanra, D. J. Roberts, Z. McQuilten, C. So-Osman, L. J. Estcourt and N. Skoetz, "Convalescent plasma or hyperimmune immunoglobulin for people with COVID‐19: a living systematic review", Cochrane Database of Systematic Reviews, vol. 2021, pp. CD013600, 2021.
DOI:10.1002/14651858.CD013600.pub4
F. Beierle and et al, "Corona Health—A Study- and Sensor-Based Mobile App Platform Exploring Aspects of the COVID-19 Pandemic", Int J Environ Res Public Health, vol. 18, pp. 7395, 2021.
DOI:10.3390/ijerph18147395
P. Fervers, J. Kottlors, N. Große Hokamp, J. Bremm, D. Maintz, S. Tritt, O. Safarov, T. Persigehl, N. Vollmar, P. M. Bansmann and N. Abdullayev, "Coronary artery calcification on low-dose chest CT is an early predictor of severe progression of COVID-19-A multi-center, multi-vendor study", PloS one, vol. 16, no. 7, pp. e0255045, 2021.
DOI:10.1371/journal.pone.0255045
Datei:https://pubmed.ncbi.nlm.nih.gov/34288966/

Abstract:
Cardiovascular comorbidity anticipates severe progression of COVID-19 and becomes evident by coronary artery calcification (CAC) on low-dose chest computed tomography (LDCT). The purpose of this study was to predict a patient's obligation of intensive care treatment by evaluating the coronary calcium burden on the initial diagnostic LDCT. Eighty-nine consecutive patients with parallel LDCT and positive RT-PCR for SARS-CoV-2 were included from three centers. The primary endpoint was admission to ICU, tracheal intubation, or death in the 22-day follow-up period. CAC burden was represented by the Agatston score. Multivariate logistic regression was modeled for prediction of the primary endpoint by the independent variables "Agatston score > 0", as well as the CT lung involvement score, patient sex, age, clinical predictors of severe COVID-19 progression (history of hypertension, diabetes, prior cardiovascular event, active smoking, or hyperlipidemia), and laboratory parameters (creatinine, C-reactive protein, leucocyte, as well as thrombocyte counts, relative lymphocyte count, d-dimer, and lactate dehydrogenase levels). After excluding multicollinearity, "Agatston score >0" was an independent regressor within multivariate analysis for prediction of the primary endpoint (p<0.01). Further independent regressors were creatinine (p = 0.02) and leucocyte count (p = 0.04). The Agatston score was significantly higher for COVID-19 cases which completed the primary endpoint (64.2 [interquartile range 1.7-409.4] vs. 0 [interquartile range 0-0]). CAC scoring on LDCT might help to predict future obligation of intensive care treatment at the day of patient admission to the hospital.
S. Steudte-Schmiedgen, L. Stieler, Y. Erim, E. Morawa, F. Geiser, P. Beschoner, L. Jerg-Bretzke, N. Hiebel and K. Weidner, "Correlates and Predictors of PTSD Symptoms Among Healthcare Workers During the COVID-19 Pandemic: Results of the egePan-VOICE Study", Frontiers in Psychiatry, vol. 12, 2021.
DOI:10.3389/fpsyt.2021.686667
Datei:https://doi.org/10.3389/fpsyt.2021.686667
A. Ebigbo, C. Römmele, C. Bartenschlager and et al, "Cost-effectiveness analysis of SARS-CoV-2 infection prevention strategies including pre-endoscopic virus testing and use of high risk personal protective equipment", Endoscopy, vol. 53, no. 2, 2021.
DOI:10.1055/a-1294-0427
M. Baumann, "COVID-19 and mental health in children and adolescents: a diagnostic panel to map psycho-social consequences in the pandemic context", Discov Ment Health, vol. 1, no. 1, pp. 2, 2021.
DOI:10.1007/s44192-021-00002-x
N. Ritschel, H. Radbruch, C. Herden, N. Schneider, C. Dittmayer and e. a. Franz, "COVID-19 and the central and peripheral nervous system", Pathologe, vol. 42, pp. 172—182, 2021.
DOI:10.1007/s00292-021-00923-w
Q. Ul Ain, A. Hocke and S. Hedtrich, "COVID-19 highlights the model dilemma in biomedical research", Nat Rev Mater, pp. 1—3, 2021.
W. Roth and P. Boor, "COVID-19 im Spiegel der Pathologie [COVID-19 in the mirror of pathology]", Pathologe, vol. 42, no. 2, pp. 147-148, 2021.
E. Gaitzsch, V. Passerini, E. Khatamzas and et al, "COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma", Hemasphere, vol. 5, no. 7, 2021.
DOI:10.1097/HS9.000000000000060
E. Gaitzsch and et al, "COVID-19 in Patients Receiving CD20-depleting Immunochemotherapy for B-cell Lymphoma", HemaSphere, vol. 5, pp. e603, 2021.
DOI:10.1097/HS9.0000000000000603
S. Heinemann, A. Bludau, H. Kaba and et al, "COVID-19 surveillance and testing strategies für patiens in German hospitals – results from a cross-sectional study", DGHM, 2021.
Datei:https://www.egms.de/static/de/journals/dgkh/2021-16/dgkh000402.shtml
R. Tanacli, P. Doeblin, C. Götze, V. Zieschang, A. Faragli, C. Stehning, G. Korosoglou, J. Erley, J. Weiss, A. Berger and D. Stahl, "COVID-19 vs. Classical Myocarditis Associated Myocardial Injury Evaluated by Cardiac Magnetic Resonance and Endomyocardial Biopsy", Front Cardiovasc Med, vol. 8, pp. 737257, 2021.
DOI:10.3389/fcvm.2021.737257
P. Boor, T. Wiech, J. Singh, E. Vonbrunn, A. Knöll, M. Hermann, M. Büttner-Herold, C. Daniel and A. Hartmann, "COVID-19-Auswirkungen auf die Niere [COVID-19 effects on the kidney]", Pathologe, vol. 42, no. 2, pp. 183-187, 2021.
C. Seeber, M. Popp, J. Meerpohl and et al, "COVID-19-Pandemie: Präferenzen und Barrieren für die Disseminierung von Evidenzsynthesen", Anaesthesist, 2021.
DOI:10.1007/s00101-021-01037-z
K. Polotzek, A. Karch, J. Karschau, M. Wagner, B. Lünsmann, M. Menk, C. Römmele and J. Schmitt, "COVID-19-Pandemie: Regionale Steuerung der Patienten", Dtsch Arztebl International, vol. 118, no. 3, pp. 84—, 2021.
C. Werlein, F. Länger, M. P. Kühnel and D. D. Jonigk, "COVID-19: Auswirkungen auf Lunge und Herz [COVID-19: effects on the lungs and heart]", Pathologe, vol. 42, no. 2, pp. 164-171, 2021.
L. Loyal, J. Braun, L. Henze, B. Kruse, M. Dingeldey and e. a. Reimer, "Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination", Science, 2021.
L. Loyal and et al, "Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination", Science (New York, N.Y.), 2021.
DOI:10.1126/science.abh1823
J. Trimpert and et al, "Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters", Viruses, vol. 13, 2021.
DOI:10.3390/v13112290
M. Schwabenland, H. Salié, J. Tanevski, S. Killmer, M. Lago, A. Schlaak, L. Mayer, J. Matschke, K. Püschel, A. Fitzek, B. Ondruschka, H. Mei, T. Boettler, C. Neumann-Haefelin, M. Hofmann, A. Breithaupt, N. Genc, C. Stadelmann, J. Saez-Rodriguez, P. Bronsert, K. Knobeloch, T. Blank, R. Thimme, M. Glatzel, M. Prinz and B. Bengsch, "Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions", Immunity, vol. 54, no. 7, pp. 1594-1610.e11, 2021.
DOI:10.1016/j.immuni.2021.06.002
T. Schwarz and et al, "Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany", Emerging infectious diseases, vol. 27, 2021.
DOI:10.3201/eid2708.211145
N. -. Hoff and et al, "Delayed skin reaction after mRNA-1273 vaccine against SARS-CoV-2: a rare clinical reaction", European Journal of Medical Research, vol. 26, pp. 98, 2021.
DOI:10.1186/s40001-021-00557-z
P. Arora and et al, "Delta variant (B.1.617.2) sublineages do not show increased neutralization resistance", Cellular & Molecular Immunology, vol. 18, pp. 2557—2559, 2021.
DOI:10.1038/s41423-021-00772-y
M. Baumann, M. Berghäuser, T. Bolz and T. Martens, "Den Fokus neu denken - Skizze eines Pandemiemanagements auf Grundlage der Bedürfnisse und Lern- und Entwicklungserfordernissen von Kindern, Jugendlichen und Familien", 2021.
M. Casagrande, A. Fitzek, M. Spitzer, K. Püschel, M. Glatzel, S. Krasemann, D. Nörz, M. Lütgehetmann, S. Pfefferle and M. Schultheiss, "Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19", Br J Ophthalmol, vol. 105, no. 8, pp. 1057-1061, 2021.
M. Döpfner, C. Habbel and et al, "Die psychische Belastung von Kindern und Jugendlichen und ihren Familien während der COVID-19-Pandemie und der Zusammenhang mit emotionalen und Verhaltensauffälligkeiten", Bundesgesundheitsbl, vol. 64, 2021.
DOI:10.1007/s00103-021-03455-1
M. Döpfner, C. Habbel, B. Schulte, K. Schulze-Husmann, M. Simons, F. Heuer, C. Wegner, S. Bender, B. Herpertz-Dahlmann and D. Stahl, "Die psychische Belastung von Kindern, Jugendlichen und ihren Familien während der COVID-19-Pandemie und der Zusammenhang mit emotionalen und Verhaltensauffälligkeiten", Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, vol. 64, no. 12, pp. 1522—1532, 2021.
DOI:10.1007/s00103-021-03455-1
A. Schuppert, K. Polotzek, J. Schmitt, R. Busse, J. Karschau and C. Karagiannidis, "Different spreading dynamics throughout Germany during the second wave of the COVID-19 pandemic: A time series study based on national surveillance data", The Lancet Regional Health - Europe, vol. 6, pp. 100151, 2021.
DOI:10.1016/j.lanepe.2021.100151
Datei:https://doi.org/10.1016/j.lanepe.2021.100151
R. J. Neumann, B. Kollmann, M. M. Plichta, K. Lieb, O. Tüscher and A. Reif, "Differential impact of COVID-related lockdown on mental health in Germany", World Psychiatry, vol. 20, no. 1, pp. 140—141, 2021.
DOI:10.1002/wps.20830
K. Vanshylla and et al, "Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers", Cell host & microbe, 2021.
DOI:10.1016/j.chom.2021.12.010
S. Schlickeiser, T. Schwarz, S. Steiner, K. Wittke, O. Meyer, U. Kalus, A. Pruß, F. Kurth, T. Zoller and D. Stahl, "Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses", Front Immunol, vol. 11, pp. 628971, 2021.
DOI:10.3389/fimmu.2020.628971
F. Heinrich, C. Romich, T. Zimmermann, I. Kniep, A. Fitzek, S. Steurer, M. Glatzel, D. Nörz, T. Günther, M. Czech-Sioli, N. Fischer, A. Grundhoff, M. Lütgehetmann and B. Ondruschka, "Dying of VOC-202012/01 - multimodal investigations in a death case of the SARS-CoV-2 variant", Int J Legal Med, pp. 1-10, 2021.
DOI:10.1007/s00414-021-02618-8
S. Deinhardt-Emmer, D. Wittschieber, J. Sanft, S. Kleemann, S. Elschner and e. a. Haupt, "Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage", Elife, vol. 10, 2021.
L. Gieselmann and et al, "Effective high-throughput isolation of fully human antibodies targeting infectious pathogens", Nature Protocols, 2021.
DOI:10.1038/s41596-021-00554-w
A. Deckert and D. Stahl, "Effectiveness and cost-effectiveness of four different strategies for SARS-CoV-2 surveillance in the general population (CoV-Surv Study): a structured summary of a study protocol for a cluster-randomised, two-factorial controlled trial", Trials, vol. 22, no. 1, 2021.
DOI:10.1186/s13063-020-04982-z
Datei:https://doi.org/10.1186/s13063-020-04982-z