Publikationen im NUM
Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.
K. Subbarayan,
K. Ulagappan,
C. Wickenhauser and
B. Seliger,
"Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues",
Current Cancer Drug Targets,
vol. 21,
no. 5,
pp. 428—442,
Jul.
2021.
| DOI: | 10.2174/1568009620666201207145019 |
| Datei: | https://www.eurekaselect.com/article/112117 |
D. W. L. Wong,
B. M. Klinkhammer,
S. Djudjaj,
S. Villwock,
M. C. Timm,
E. M. Buhl,
S. Wucherpfennig,
C. Cacchi,
T. Braunschweig,
R. Knüchel-Clarke,
D. Jonigk,
C. Werlein,
R. D. Bülow,
E. Dahl,
S. Stillfried and
P. Boor,
"Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients",
Cells,
vol. 10,
no. 8,
pp. 1900,
Jul.
2021.
| DOI: | 10.3390/cells10081900 |
| Datei: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394956/ |
S. Stillfried,
S. Villwock,
R. D. Bülow,
S. Djudjaj,
E. Buhl,
A. Maurer,
N. Ortiz-Brüchle,
P. Celec,
B. M. Klinkhammer,
D. W. Wong,
C. Cacchi,
T. Braunschweig,
R. Knüchel-Clarke,
E. Dahl and
P. Boor,
"SARS-CoV-2 RNA screening in routine pathology specimens",
Microb Biotechnol,
vol. 14,
no. 4,
pp. 1627-1641,
Jul.
2021.
| DOI: | 10.1111/1751-7915.13828 |
[en]
S. Stillfried,
S. Villwock,
R. D. Bülow,
S. Djudjaj,
E. M. Buhl,
A. Maurer,
N. Ortiz-Brüchle,
P. Celec,
B. M. Klinkhammer,
D. W. L. Wong,
C. Cacchi,
T. Braunschweig,
R. Knüchel-Clarke,
E. Dahl and
P. Boor,
"SARS-CoV-2 RNA screening in routine pathology specimens",
Microbial Biotechnology,
vol. 14,
no. 4,
pp. 1627—1641,
Jul.
2021.
| DOI: | 10.1111/1751-7915.13828 |
| Datei: | https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-7915.13828 |
[en]
M. O'Hare,
D. Amarnani,
H. A. B. Whitmore,
M. An,
C. Marino,
L. Ramos,
S. Delgado-Tirado,
X. Hu,
N. Chmielewska,
A. Chandrahas,
A. Fitzek,
F. Heinrich,
S. Steurer,
B. Ondruschka,
M. Glatzel,
S. Krasemann,
D. Sepulveda-Falla,
D. Lagares,
J. Pedron,
J. H. Bushweller,
P. Liu,
J. F. Arboleda-Velasquez and
L. A. Kim,
"Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators",
The American Journal of Pathology,
vol. 191,
no. 7,
pp. 1193—1208,
Jul.
2021.
| DOI: | 10.1016/j.ajpath.2021.04.006 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S0002944021001619 |
C. Grimm,
S. Dickel,
A. Sachkova,
M. Popp,
M. Golinksi,
F. Fichtner,
P. Kranke,
C. Seeber,
S. Laudi,
S. Voigt-Radloff and
O. Moerer,
"Targeted Minimal Staff-to-Patient Ratios Are Unachievable - A Nationwide Survey in German ICUs During the COVID-19 Pandemic",
Cureus,
vol. 13,
no. 6,
pp. e15755,
Jun.
2021.
| DOI: | 10.7759/cureus.15755 |
M. Metzendorf and
R. M. Featherstone,
"Evaluation of the comprehensiveness, accuracy and currency of the Cochrane COVID-19 Study Register for supporting rapid evidence synthesis production",
Res Synth Methods,
Jun.
2021.
| DOI: | 10.1002/jrsm.1501 |
J. Schaible,
S. Meiler,
F. Poschenrieder,
G. Scharf,
F. Zeman,
C. Knobloch,
J. Rennert,
B. Pregler,
H. Kleine,
C. Menzel,
C. Stroszczynski,
N. Zorger and
O. W. Hamer,
"CT Features of COVID-19 Pneumonia Differ Depending on the Severity and Duration of Disease",
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
vol. 193,
no. 6,
pp. 672-682,
Jun.
2021.
Abstract:
CT is important in the care of patients with COVID-19 pneumonia. However, CT morphology can change significantly over the course of the disease. To evaluate the CT morphology of RT-PCR-proven COVID-19 pneumonia in a German cohort with special emphasis on identification of potential differences of CT features depending on duration and severity of disease. All patients with RT-PCR-proven COVID-19 pneumonia and chest CT performed between March 1 and April 15, 2020 were retrospectively identified. The CT scans were evaluated regarding the presence of different CT features (e. g. ground glass opacity, consolidation, crazy paving, vessel enlargement, shape, and margin of opacifications), distribution of lesions in the lung and extent of parenchymal involvement. For subgroup analyses the patients were divided according to the percentage of parenchymal opacification (0-33 %, 34-66 %, 67-100 %) and according to time interval between symptom onset and CT date (0-5 d, 6-10 d, 11-15 d, > 15 d). Differences in CT features and distribution between subgroups were tested using the Mantel-Haenszel Chi Squared for trend. The frequency of CT features (ground glass opacity, consolidation, crazy paving, bronchial dilatation, vessel enlargement, lymphadenopathy, pleural effusion) as well as pattern of parenchymal involvement differed significantly depending on the duration of disease and extent of parenchymal involvement. The early phase of disease was characterized by GGO and to a lesser extent consolidation. The opacifications tended to be round and to some extent with sharp margins and a geographic configuration. The vessels within/around the opacifications were frequently dilated. Later on, the frequency of consolidation and especially crazy paving increased, and the round/geographic shape faded. After day 15, bronchial dilatation occurred, and lymphadenopathy and pleural effusion were seen more frequently than before. The prevalence of CT features varied considerably during the course of disease and depending on the severity of parenchymal involvement. Radiologists should take into account the time interval between symptom onset and date of CT and the severity of disease when discussing the likelihood of COVID-19 pneumonia based on CT morphology. · The frequency of CT features and pattern of parenchymal involvement vary depending on the duration and extent of COVID-19 pneumonia.. · The early phase is characterized by GGO and consolidation which demonstrate a round shape and at least to some extent have sharp margins and a geographic configuration.. · The frequency of consolidation and especially crazy paving increases during the course of disease.. · Beyond day 15 after symptom onset, bronchial dilatation occurs.. · Radiologists should take into account the duration and severity of disease when considering COVID-19 pneumonia.. · Schaible J, Meiler S, Poschenrieder F et al. CT Features of COVID-19 Pneumonia Differ Depending on the Severity and Duration of Disease. Fortschr Röntgenstr 2021; 193: 672 - 682.
| DOI: | 10.1055/a-1293-9163 |
| Datei: | https://pubmed.ncbi.nlm.nih.gov/33336354/ |
Abstract:
CT is important in the care of patients with COVID-19 pneumonia. However, CT morphology can change significantly over the course of the disease. To evaluate the CT morphology of RT-PCR-proven COVID-19 pneumonia in a German cohort with special emphasis on identification of potential differences of CT features depending on duration and severity of disease. All patients with RT-PCR-proven COVID-19 pneumonia and chest CT performed between March 1 and April 15, 2020 were retrospectively identified. The CT scans were evaluated regarding the presence of different CT features (e. g. ground glass opacity, consolidation, crazy paving, vessel enlargement, shape, and margin of opacifications), distribution of lesions in the lung and extent of parenchymal involvement. For subgroup analyses the patients were divided according to the percentage of parenchymal opacification (0-33 %, 34-66 %, 67-100 %) and according to time interval between symptom onset and CT date (0-5 d, 6-10 d, 11-15 d, > 15 d). Differences in CT features and distribution between subgroups were tested using the Mantel-Haenszel Chi Squared for trend. The frequency of CT features (ground glass opacity, consolidation, crazy paving, bronchial dilatation, vessel enlargement, lymphadenopathy, pleural effusion) as well as pattern of parenchymal involvement differed significantly depending on the duration of disease and extent of parenchymal involvement. The early phase of disease was characterized by GGO and to a lesser extent consolidation. The opacifications tended to be round and to some extent with sharp margins and a geographic configuration. The vessels within/around the opacifications were frequently dilated. Later on, the frequency of consolidation and especially crazy paving increased, and the round/geographic shape faded. After day 15, bronchial dilatation occurred, and lymphadenopathy and pleural effusion were seen more frequently than before. The prevalence of CT features varied considerably during the course of disease and depending on the severity of parenchymal involvement. Radiologists should take into account the time interval between symptom onset and date of CT and the severity of disease when discussing the likelihood of COVID-19 pneumonia based on CT morphology. · The frequency of CT features and pattern of parenchymal involvement vary depending on the duration and extent of COVID-19 pneumonia.. · The early phase is characterized by GGO and consolidation which demonstrate a round shape and at least to some extent have sharp margins and a geographic configuration.. · The frequency of consolidation and especially crazy paving increases during the course of disease.. · Beyond day 15 after symptom onset, bronchial dilatation occurs.. · Radiologists should take into account the duration and severity of disease when considering COVID-19 pneumonia.. · Schaible J, Meiler S, Poschenrieder F et al. CT Features of COVID-19 Pneumonia Differ Depending on the Severity and Duration of Disease. Fortschr Röntgenstr 2021; 193: 672 - 682.
[en]
T. Hansen,
U. Titze,
N. S. A. Kulamadayil-Heidenreich,
S. Glombitza,
J. J. Tebbe,
C. Röcken,
B. Schulz,
M. Weise and
L. Wilkens,
"First case of postmortem study in a patient vaccinated against SARS-CoV-2",
International Journal of Infectious Diseases,
vol. 107,
pp. 172—175,
Jun.
2021.
| DOI: | 10.1016/j.ijid.2021.04.053 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S1201971221003647 |
[en]
D. Nörz,
S. Pfefferle,
M. Grunwald,
N. Fischer,
M. Aepfelbacher and
M. Lütgehetmann,
"Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay",
The Journal of Molecular Diagnostics,
vol. 23,
no. 6,
pp. 777—778,
Jun.
2021.
| DOI: | 10.1016/j.jmoldx.2021.03.007 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S1525157821000891 |
[en]
M. Fuest,
P. Boor,
R. Knuechel,
For The DeRegCOVID,
P. Walter and
S. Salla,
"Postmortem conjunctival and nasopharyngeal swabs in SARS-CoV-2 infected and uninfected patients",
Acta Ophthalmologica,
vol. 99,
no. 4,
pp. e615—e617,
Jun.
2021.
| DOI: | 10.1111/aos.14559 |
| Datei: | https://onlinelibrary.wiley.com/doi/abs/10.1111/aos.14559 |
[Deutsch]
M. Verhoff,
K. Püschel and
B. Ondruschka,
"SARS-CoV-2: Was bei der Leichenschau infizierter Verstorbener zu beachten ist",
MMW - Fortschritte der Medizin,
vol. 12/2021,
no. 163,
pp. 56—58,
Jun.
2021.
| Datei: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8214379/ |
[en]
K. Althaus,
P. Möller,
G. Uzun,
A. Singh,
A. Beck,
M. Bettag,
H. Bösmüller,
M. Guthoff,
F. Dorn,
G. C. Petzold,
H. Henkes,
N. Heyne,
H. Jumaa,
K. Kreiser,
C. Limpach,
B. Luz,
M. Maschke,
J. A. Müller,
J. Münch,
S. Nagel,
B. Pötzsch,
J. Müller,
C. Schlegel,
A. Viardot,
H. Bäzner,
M. Wolf,
L. Pelzl,
V. Warm,
W. A. Willinek,
J. Steiner,
N. Schneiderhan-Marra,
D. Vollherbst,
U. J. Sachs,
F. Fend and
T. Bakchoul,
"Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia",
Haematologica,
vol. 106,
no. 8,
pp. 2170—2179,
Mai
2021.
| DOI: | 10.3324/haematol.2021.279000 |
| Datei: | https://haematologica.org/article/view/haematol.2021.279000 |
[en]
H. Englert,
C. Rangaswamy,
C. Deppermann,
J. Sperhake,
C. Krisp,
D. Schreier,
E. Gordon,
S. Konrath,
M. Haddad,
G. Pula,
R. K. Mailer,
H. Schlüter,
S. Kluge,
F. Länger,
K. Püschel,
K. Panousis,
E. X. Stavrou,
C. Maas,
T. Renné and
M. Frye,
"Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation",
EBioMedicine,
vol. 67,
pp. 103382,
Mai
2021.
| DOI: | 10.1016/j.ebiom.2021.103382 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S2352396421001754 |
[en]
V. van Rüth,
H. -. König,
F. Bertram,
P. Schmiedel,
B. Ondruschka,
K. Püschel,
F. Heinrich and
A. Hajek,
"Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic",
Public Health,
vol. 194,
pp. 60—66,
Mai
2021.
| DOI: | 10.1016/j.puhe.2021.02.026 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S0033350621000858 |
C. Trigaux,
S. Salla,
J. Schroeter,
T. Tourtas,
H. Thomasen,
P. Maier,
O. J. C. Hellwinkel,
I. Wittmershaus,
P. R. Merz,
B. Seitz,
B. Nölle,
N. Schrage,
S. Roters,
M. Apel,
A. Gareiss-Lok,
C. E. Uhlig,
S. Thaler,
F. Raber,
D. Kampik,
G. Geerling and
J. Menzel-Severing,
"SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks",
Current Eye Research,
vol. 46,
no. 5,
pp. 666—671,
Mai
2021.
| DOI: | 10.1080/02713683.2020.1828487 |
| Datei: | https://doi.org/10.1080/02713683.2020.1828487 |
[en]
T. Bayyoud,
A. Iftner,
T. Iftner,
K. U. Bartz-Schmidt,
F. Ziemssen,
H. Bösmüller,
F. Fend,
J. M. Rohrbach,
M. Ueffing,
M. Schindler and
S. Thaler,
"Severe acute respiratory Syndrome-Coronavirus-2: Can it be detected in the retina?",
PLOS ONE,
vol. 16,
no. 5,
pp. e0251682,
Mai
2021.
| DOI: | 10.1371/journal.pone.0251682 |
| Datei: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251682 |
D. Tampe,
S. Hakroush,
M. Bösherz,
J. Franz,
H. Hofmann-Winkler,
S. Pöhlmann,
S. Kluge,
O. Moerer,
C. Stadelmann,
P. Ströbel,
M. S. Winkler and
B. Tampe,
"Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study",
Frontiers in Medicine,
vol. 8,
pp. 644715,
Mai
2021.
| DOI: | 10.3389/fmed.2021.644715 |
| Datei: | https://www.frontiersin.org/articles/10.3389/fmed.2021.644715 |
K. Cramer and
D. Stahl,
"Border Restrictions and Cross-Border Care Relations: The Case of Germany and Vietnam" ,
Mai
2021.
J. Swoboda,
D. Wittschieber,
J. Sanft,
S. Kleemann,
S. Elschner,
H. Ihle,
M. Hubig,
M. Pletz,
G. Mall and
N. Gassler,
"Bone marrow haemophagocytosis indicates severe infection with severe acute respiratory syndrome coronavirus 2",
Histopathology,
vol. 78,
no. 5,
pp. 727-737,
Apr.
2021.
| DOI: | 10.1111/his.14281 |
[en]
J. Swoboda,
D. Wittschieber,
J. Sanft,
S. Kleemann,
S. Elschner,
H. Ihle,
M. Hubig,
M. W. Pletz,
G. Mall and
N. Gaßler,
"Bone marrow haemophagocytosis indicates severe infection with severe acute respiratory syndrome coronavirus 2",
Histopathology,
vol. 78,
no. 5,
pp. 727—737,
Apr.
2021.
| DOI: | 10.1111/his.14281 |
| Datei: | https://onlinelibrary.wiley.com/doi/abs/10.1111/his.14281 |
[en]
I. Kniep,
A. Heinemann,
C. Edler,
J. P. Sperhake,
K. Püschel,
B. Ondruschka and
A. S. Schröder,
"COVID-19 lungs in post-mortem computed tomography",
Rechtsmedizin,
vol. 31,
no. 2,
pp. 145—147,
Apr.
2021.
| DOI: | 10.1007/s00194-021-00462-z |
| Datei: | https://doi.org/10.1007/s00194-021-00462-z |
A. Hajek,
F. Bertram,
F. Heinrich,
V. Rüth,
B. Ondruschka,
B. Kretzler,
C. Schüler,
K. Püschel and
H. König,
"Determinants of health care use among homeless individuals: evidence from the Hamburg survey of homeless individuals",
BMC Health Services Research,
vol. 21,
no. 1,
pp. 317,
Apr.
2021.
| DOI: | 10.1186/s12913-021-06314-6 |
| Datei: | https://doi.org/10.1186/s12913-021-06314-6 |
[en]
F. Olearo,
D. Nörz,
F. Heinrich,
J. P. Sutter,
K. Roedl,
A. Schultze,
J. Wiesch,
P. Braun,
L. Oestereich,
B. Kreuels,
D. Wichmann,
M. Aepfelbacher,
S. Pfefferle and
M. Lütgehetmann,
"Handling and accuracy of four rapid antigen tests for the diagnosis of SARS-CoV-2 compared to RT-qPCR",
Journal of Clinical Virology,
vol. 137,
pp. 104782,
Apr.
2021.
| DOI: | 10.1016/j.jcv.2021.104782 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S1386653221000494 |
[en]
M. Ricke-Hoch,
E. Stelling,
L. Lasswitz,
A. P. Gunesch,
M. Kasten,
F. J. Zapatero-Belinchón,
G. Brogden,
G. Gerold,
T. Pietschmann,
V. Montiel,
J. Balligand,
F. Facciotti,
E. Hirsch,
T. Gausepohl,
H. Elbahesh,
G. F. Rimmelzwaan,
A. Höfer,
M. P. Kühnel,
D. Jonigk,
J. Eigendorf,
U. Tegtbur,
L. Mink,
M. Scherr,
T. Illig,
A. Schambach,
T. J. Pfeffer,
A. Hilfiker,
A. Haverich and
D. Hilfiker-Kleiner,
"Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease",
PLOS ONE,
vol. 16,
no. 8,
pp. e0255335,
Apr.
2021.
| DOI: | 10.1371/journal.pone.0255335 |
| Datei: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255335 |
M. Casagrande,
A. Fitzek,
M. S. Spitzer,
K. Püschel,
M. Glatzel,
S. Krasemann,
D. Nörz,
M. Lütgehetmann,
S. Pfefferle and
M. Schultheiss,
"Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19",
JAMA Ophthalmology,
vol. 139,
no. 4,
pp. 383—388,
Apr.
2021.
| DOI: | 10.1001/jamaophthalmol.2020.6339 |
| Datei: | https://doi.org/10.1001/jamaophthalmol.2020.6339 |
K. Cramer and
D. Stahl,
"Exploring Disruption and Response in International Cross-Country Comparison" ,
Apr.
2021.
A. Surov,
C. March and
M. Pech,
"[Curricular teaching during the COVID-19-pandemic : Evaluation of an online-based teaching concept]",
Der Radiologe,
vol. 61,
no. 3,
pp. 300-306,
Mä.
2021.
Abstract:
The COVID-19 pandemic has created multiple challenges for health care, social and economic systems worldwide, but also for school and university teaching. Most learning has been shifted to online classes. So far, it is unclear whether these changes are well received within the student body. The aim of this study was the evaluation of a newly developed online-based teaching concept for medical students studying radiology during the COVID-19 pandemic. The concept consisted of 12 online seminars of the 11-week course "Imaging Procedures", which were combined with 31 prerecorded video presentations. Five weeks after the start of the summer term, we conducted an anonymous online survey, which consisted of 12 questions and a box for additional comments. Furthermore, we analysed the number of requests of the presentations, the duration and the average viewing time. In all, 110 of 213 students (51.6%) completed the survey; 72.7% stated that the new teaching concept drew their interest for radiology, 78.2% agreed that it incited self-study as well as would facilitate time- and place-independent learning (95.5%). The majority indicated that the time investment for the video presentations was appropriate, but shorter video sections would simplify the learning process (70.9%) and the ideal timeframe would be 10-20 min. The majority (80.9%) agreed that the concept should be maintained in upcoming semesters. This newly developed online-based teaching concept enjoys high acceptance rates among students. It offers advantages such as time- and location-independent learning, possibilities for self-study and should be maintained in upcoming semesters after the end of social distancing due to the COVID-19 pandemic.
| DOI: | 10.1007/s00117-020-00793-0 |
| Datei: | https://pubmed.ncbi.nlm.nih.gov/33416926/ |
Abstract:
The COVID-19 pandemic has created multiple challenges for health care, social and economic systems worldwide, but also for school and university teaching. Most learning has been shifted to online classes. So far, it is unclear whether these changes are well received within the student body. The aim of this study was the evaluation of a newly developed online-based teaching concept for medical students studying radiology during the COVID-19 pandemic. The concept consisted of 12 online seminars of the 11-week course "Imaging Procedures", which were combined with 31 prerecorded video presentations. Five weeks after the start of the summer term, we conducted an anonymous online survey, which consisted of 12 questions and a box for additional comments. Furthermore, we analysed the number of requests of the presentations, the duration and the average viewing time. In all, 110 of 213 students (51.6%) completed the survey; 72.7% stated that the new teaching concept drew their interest for radiology, 78.2% agreed that it incited self-study as well as would facilitate time- and place-independent learning (95.5%). The majority indicated that the time investment for the video presentations was appropriate, but shorter video sections would simplify the learning process (70.9%) and the ideal timeframe would be 10-20 min. The majority (80.9%) agreed that the concept should be maintained in upcoming semesters. This newly developed online-based teaching concept enjoys high acceptance rates among students. It offers advantages such as time- and location-independent learning, possibilities for self-study and should be maintained in upcoming semesters after the end of social distancing due to the COVID-19 pandemic.
[de]
S. Traxler,
M. Schindler,
H. Bösmüller and
K. Klingel,
"Biologie und Pathologie von Coronaviren",
Der Pathologe,
vol. 42,
no. 2,
pp. 149—154,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00923-y |
| Datei: | https://doi.org/10.1007/s00292-021-00923-y |
A. Walker,
T. Houwaart,
P. Finzer,
L. Ehlkes,
A. Tyshaieva,
M. Damagnez,
D. Strelow,
A. Duplessis,
J. Nicolai,
T. Wienemann,
T. Tamayo,
M. Kohns Vasconcelos,
L. Hülse,
K. Hoffmann,
N. Lübke,
S. Hauka,
M. Andree,
M. Däumer,
A. Thielen,
S. Kolbe-Busch,
K. Göbels,
R. Zotz,
K. Pfeffer,
J. Timm,
A. Dilthey and
German COVID-19 OMICS Initiative (DeCOI),
"Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting",
Clin Infect Dis,
no. 6,
pp. 1039-1046,
Mä.
2021.
| DOI: | 10.1093/cid/ciab588 |
A. Walker,
T. Houwaart,
P. Finzer,
L. Ehlkes,
A. Tyshaieva,
M. Damagnez,
D. Strelow,
A. Duplessis,
J. Nicolai,
T. Wienemann,
T. Tamayo,
M. Kohns Vasconcelos,
L. Hülse,
K. Hoffmann,
N. Lübke,
S. Hauka,
M. Andree,
M. Däumer,
A. Thielen,
S. Kolbe-Busch,
K. Göbels,
R. Zotz,
K. Pfeffer,
J. Timm,
A. Dilthey and
German COVID-19 OMICS Initiative (DeCOI),
"Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Clusters Based on Integrated Genomic Surveillance, Outbreak Analysis and Contact Tracing in an Urban Setting",
Clin Infect Dis,
no. 6,
pp. 1039-1046,
Mä.
2021.
| DOI: | 10.1093/cid/ciab588 |
[de]
W. Roth and
P. Boor,
"COVID-19 im Spiegel der Pathologie",
Der Pathologe,
vol. 42,
no. 2,
pp. 147—148,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00916-x |
| Datei: | https://doi.org/10.1007/s00292-021-00916-x |
[de]
K. Amann,
P. Boor,
T. Wiech,
J. Singh,
E. Vonbrunn,
A. Knöll,
M. Hermann,
M. Büttner-Herold,
C. Daniel and
A. Hartmann,
"COVID-19-Auswirkungen auf die Niere",
Der Pathologe,
vol. 42,
no. 2,
pp. 183—187,
Mä.
2021.
| DOI: | 10.1007/s00292-020-00899-1 |
| Datei: | https://doi.org/10.1007/s00292-020-00899-1 |
[de]
N. Ritschel,
N. Schneider,
C. Dittmayer,
J. Franz,
C. Thomas,
G. Silva Boos,
K. Sohrabi,
A. Schänzer,
A. Németh,
D. „CNS-COVID19“ and
„. P. N. R. COVID-19“,
"COVID-19: Auswirkungen auf das zentrale und periphere Nervensystem",
Der Pathologe,
vol. 42,
no. 2,
pp. 172—182,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00924-x |
| Datei: | https://doi.org/10.1007/s00292-021-00924-x |
[de]
M. Ackermann,
C. Werlein,
F. Länger,
M. P. Kühnel and
D. D. Jonigk,
"COVID-19: Auswirkungen auf Lunge und Herz",
Der Pathologe,
vol. 42,
no. 2,
pp. 164—171,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00918-9 |
| Datei: | https://doi.org/10.1007/s00292-021-00918-9 |
J. Kottlors,
N. Große Hokamp,
P. Fervers,
J. Bremm,
F. Fichter,
T. Persigehl,
O. Safarov,
D. Maintz,
S. Tritt and
N. Abdullayev,
"Early extrapulmonary prognostic features in chest computed tomography in COVID-19 pneumonia: Bone mineral density is a relevant predictor for the clinical outcome - A multicenter feasibility study",
Bone,
vol. 144,
pp. 115790,
Mä.
2021.
Abstract:
Besides throat-nose swab polymerase chain reaction (PCR), unenhanced chest computed tomography (CT) is a recommended diagnostic tool for early detection and quantification of pulmonary changes in COVID-19 pneumonia caused by the novel corona virus. Demographic factors, especially age and comorbidities, are major determinants of the outcome in COVID-19 infection. This study examines the extra pulmonary parameter of bone mineral density (BMD) from an initial chest computed tomography as an associated variable of pre-existing comorbidities like chronic lung disease or demographic factors to determine the later patient's outcome, in particular whether treatment on an intensive care unit (ICU) was necessary in infected patients. We analyzed 58 PCR-confirmed COVID-19 infections that received an unenhanced CT at admission at one of the included centers. In addition to the extent of pulmonary involvement, we performed a phantomless assessment of bone mineral density of thoracic vertebra 9-12. In a univariate regression analysis BMD was found to be a significant predictor of the necessity for intensive care unit treatment of COVID-19 patients. In the subgroup requiring intensive care treatment within the follow-up period a significantly lower BMD was found. In a multivariate logistic regression model considering gender, age and CT measurements of bone mineral density, BMD was eliminated from the regression analysis as a significant predictor. Phantomless assessed BMD provides prognostic information on the necessity for ICU treatment in course of COVID-19 pneumonia. We recommend using the measurement of BMD in an initial CT image to facilitate a potentially better prediction of severe patient outcomes within the 22 days after an initial CT scan. Consequently, in the present sample, additional bone density analysis did not result in a prognostic advantage over simply considering age. Significantly larger patient cohorts with a more homogenous patient age should be performed in the future to illustrate potential effects. While clinical capacities such as ICU beds and ventilators are more crucial than ever to help manage the current global corona pandemic, this work introduces an approach that can be used in a cost-effective way to help determine the amount of these rare clinical resources required in the near future.
| DOI: | 10.1016/j.bone.2020.115790 |
| Datei: | https://pubmed.ncbi.nlm.nih.gov/33301962/ |
Abstract:
Besides throat-nose swab polymerase chain reaction (PCR), unenhanced chest computed tomography (CT) is a recommended diagnostic tool for early detection and quantification of pulmonary changes in COVID-19 pneumonia caused by the novel corona virus. Demographic factors, especially age and comorbidities, are major determinants of the outcome in COVID-19 infection. This study examines the extra pulmonary parameter of bone mineral density (BMD) from an initial chest computed tomography as an associated variable of pre-existing comorbidities like chronic lung disease or demographic factors to determine the later patient's outcome, in particular whether treatment on an intensive care unit (ICU) was necessary in infected patients. We analyzed 58 PCR-confirmed COVID-19 infections that received an unenhanced CT at admission at one of the included centers. In addition to the extent of pulmonary involvement, we performed a phantomless assessment of bone mineral density of thoracic vertebra 9-12. In a univariate regression analysis BMD was found to be a significant predictor of the necessity for intensive care unit treatment of COVID-19 patients. In the subgroup requiring intensive care treatment within the follow-up period a significantly lower BMD was found. In a multivariate logistic regression model considering gender, age and CT measurements of bone mineral density, BMD was eliminated from the regression analysis as a significant predictor. Phantomless assessed BMD provides prognostic information on the necessity for ICU treatment in course of COVID-19 pneumonia. We recommend using the measurement of BMD in an initial CT image to facilitate a potentially better prediction of severe patient outcomes within the 22 days after an initial CT scan. Consequently, in the present sample, additional bone density analysis did not result in a prognostic advantage over simply considering age. Significantly larger patient cohorts with a more homogenous patient age should be performed in the future to illustrate potential effects. While clinical capacities such as ICU beds and ventilators are more crucial than ever to help manage the current global corona pandemic, this work introduces an approach that can be used in a cost-effective way to help determine the amount of these rare clinical resources required in the near future.
K. Subbarayan,
K. Ulagappan,
C. Wickenhauser,
M. Bachmann and
B. Seliger,
"Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues",
Frontiers in Immunology,
vol. 12,
pp. 597399,
Mä.
2021.
| DOI: | 10.3389/fimmu.2021.597399 |
| Datei: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.597399 |
[de]
S. Strobl and
W. Roth,
"Internationale wissenschaftliche Publikationsaktivität zu COVID-19",
Der Pathologe,
vol. 42,
no. 2,
pp. 224—230,
Mä.
2021.
| DOI: | 10.1007/s00292-020-00892-8 |
| Datei: | https://doi.org/10.1007/s00292-020-00892-8 |
[de]
S. Stillfried,
T. Acker,
M. Aepfelbacher,
G. Baretton,
R. D. Bülow,
K. Bürrig,
H. Holtherm,
D. Jonigk,
R. Knüchel,
R. W. Majeed,
R. Röhrig,
J. Wienströer and
P. Boor,
"Kooperatives Vorgehen der Pathologie und Neuropathologie in der COVID-19-Pandemie",
Der Pathologe,
vol. 42,
no. 2,
pp. 216—223,
Mä.
2021.
| DOI: | 10.1007/s00292-020-00891-9 |
| Datei: | https://doi.org/10.1007/s00292-020-00891-9 |
[eng]
C. N. Englisch,
T. Tschernig,
F. Flockerzi,
C. Meier and
R. M. Bohle,
"Lesions in the lungs of fatal corona virus disease Covid-19",
Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft,
vol. 234,
pp. 151657,
Mä.
2021.
| DOI: | 10.1016/j.aanat.2020.151657 |
[de]
S. Stillfried and
P. Boor,
"Nachweismethoden von SARS-CoV-2 in Gewebe",
Der Pathologe,
vol. 42,
no. 2,
pp. 208—215,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00919-8 |
| Datei: | https://doi.org/10.1007/s00292-021-00919-8 |
[de]
P. Boor,
P. Eichhorn,
A. Hartmann,
S. F. Lax,
B. Märkl,
T. Menter,
K. Skok,
J. Slotta-Huspenina,
S. Stillfried,
A. Tzankov and
G. Weirich,
"Praktische Aspekte von COVID-19-Obduktionen",
Der Pathologe,
vol. 42,
no. 2,
pp. 197—207,
Mä.
2021.
| DOI: | 10.1007/s00292-021-00925-w |
| Datei: | https://doi.org/10.1007/s00292-021-00925-w |
K. Althaus,
I. Marini,
J. Zlamal,
L. Pelzl,
A. Singh,
H. Häberle,
M. Mehrländer,
S. Hammer,
H. Schulze,
M. Bitzer,
N. Malek,
D. Rath,
H. Bösmüller,
B. Nieswandt,
M. Gawaz,
T. Bakchoul and
P. Rosenberger,
"Antibody-induced procoagulant platelets in severe COVID-19 infection",
Blood,
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Feb.
2021.
| DOI: | 10.1182/blood.2020008762 |
| Datei: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791311/ |
[en]
J. Ihlow,
E. Michaelis,
S. Greuel,
V. Heynol,
A. Lehmann,
H. Radbruch,
J. Meinhardt,
F. Miller,
H. Herbst,
V. M. Corman,
J. Westermann,
L. Bullinger,
D. Horst,
A. Brünneck and
S. Elezkurtaj,
"B cell depletion and signs of sepsis-acquired immunodeficiency in bone marrow and spleen of COVID-19 deceased",
International Journal of Infectious Diseases,
vol. 103,
pp. 628—635,
Feb.
2021.
| DOI: | 10.1016/j.ijid.2020.12.078 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S1201971220326023 |
[en]
S. Elezkurtaj,
S. Greuel,
J. Ihlow,
E. G. Michaelis,
P. Bischoff,
C. A. Kunze,
B. V. Sinn,
M. Gerhold,
K. Hauptmann,
B. Ingold-Heppner,
F. Miller,
H. Herbst,
V. M. Corman,
H. Martin,
H. Radbruch,
F. L. Heppner and
D. Horst,
"Causes of death and comorbidities in hospitalized patients with COVID-19",
Scientific Reports,
vol. 11,
no. 1,
pp. 4263,
Feb.
2021.
| DOI: | 10.1038/s41598-021-82862-5 |
| Datei: | https://www.nature.com/articles/s41598-021-82862-5 |
[en]
P. Hofman,
M. Ilié,
E. Chamorey,
P. Brest,
R. Schiappa,
V. Nakache,
M. Antoine,
M. Barberis,
H. Begueret,
F. Bibeau,
C. Bonnetaud,
P. Boström,
P. Brousset,
L. Bubendorf,
L. Carvalho,
G. Cathomas,
A. Cazes,
L. Chalabreysse,
M. -. Chenard,
M. -. Copin,
J. -. Côté,
D. Damotte,
L. Leval,
P. Delongova,
V. Montpreville,
A. Muret,
A. Dema,
W. Dietmaier,
M. Evert,
A. Fabre,
F. Forest,
A. Foulet,
S. Garcia,
M. Garcia-Martos,
L. Gibault,
G. Gorkiewicz,
D. Jonigk,
J. Gosney,
A. Hofman,
I. Kern,
K. Kerr,
M. Kossai,
M. Kriegsmann,
S. Lassalle,
E. Long-Mira,
A. Lupo,
A. Mamilos,
R. Matěj,
J. Meilleroux,
C. Ortiz-Villalón,
L. Panico,
A. Panizo,
M. Papotti,
P. Pauwels,
G. Pelosi,
F. Penault-Llorca,
O. Pop,
N. Poté,
S. R. Y. Cajal,
J. -. Sabourin,
I. Salmon,
M. Sajin,
S. Savic-Prince,
H. -. Schildhaus,
P. Schirmacher,
I. Serre,
E. Shaw,
D. Sizaret,
A. Stenzinger,
J. Stojsic,
E. Thunnissen,
W. Timens,
G. Troncone,
C. Werlein,
H. Wolff,
J. -. Berthet,
J. Benzaquen,
C. -. Marquette,
V. Hofman and
F. Calabrese,
"Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future",
ESMO Open,
vol. 6,
no. 1,
pp. 100024,
Feb.
2021.
| DOI: | 10.1016/j.esmoop.2020.100024 |
| Datei: | https://www.sciencedirect.com/science/article/pii/S2059702920328891 |
D. Nörz,
A. Hoffmann,
M. Aepfelbacher,
S. Pfefferle and
M. Lütgehetmann,
"Clinical evaluation of a fully automated, laboratory-developed multiplex RT-PCR assay integrating dual-target SARS-CoV-2 and influenza A/B detection on a high-throughput platform",
Journal of Medical Microbiology,
vol. 70,
no. 2,
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Feb.
2021.
| DOI: | 10.1099/jmm.0.001295 |
| Datei: | https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.001295 |
[eng]
Y. Zhao,
C. Kilian,
J. Turner,
L. Bosurgi,
K. Roedl,
P. Bartsch,
A. Gnirck,
F. Cortesi,
C. Schultheiß,
M. Hellmig,
L. U. B. Enk,
F. Hausmann,
A. Borchers,
M. N. Wong,
H. Paust,
F. Siracusa,
N. Scheibel,
M. Herrmann,
E. Rosati,
P. Bacher,
D. Kylies,
D. Jarczak,
M. Lütgehetmann,
S. Pfefferle,
S. Steurer,
J. S. Zur-Wiesch,
V. G. Puelles,
J. Sperhake,
M. M. Addo,
A. W. Lohse,
M. Binder,
S. Huber,
T. B. Huber,
S. Kluge,
S. Bonn,
U. Panzer,
N. Gagliani and
C. F. Krebs,
"Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients",
Science Immunology,
vol. 6,
no. 56,
pp. eabf6692,
Feb.
2021.
| DOI: | 10.1126/sciimmunol.abf6692 |
J. Holz,
"Der Erfolg Vietnams im Kampf gegen das Virus",
Südostasien. Zeitschrift für Politik, Kultur, Dialog,
Feb.
2021.
[en]
J. Meinhardt,
J. Radke,
C. Dittmayer,
J. Franz,
C. Thomas,
R. Mothes,
M. Laue,
J. Schneider,
S. Brünink,
S. Greuel,
M. Lehmann,
O. Hassan,
T. Aschman,
E. Schumann,
R. L. Chua,
C. Conrad,
R. Eils,
W. Stenzel,
M. Windgassen,
L. Rößler,
H. Goebel,
H. R. Gelderblom,
H. Martin,
A. Nitsche,
W. J. Schulz-Schaeffer,
S. Hakroush,
M. S. Winkler,
B. Tampe,
F. Scheibe,
P. Körtvélyessy,
D. Reinhold,
B. Siegmund,
A. A. Kühl,
S. Elezkurtaj,
D. Horst,
L. Oesterhelweg,
M. Tsokos,
B. Ingold-Heppner,
C. Stadelmann,
C. Drosten,
V. M. Corman,
H. Radbruch and
F. L. Heppner,
"Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19",
Nature Neuroscience,
vol. 24,
no. 2,
pp. 168—175,
Feb.
2021.
| DOI: | 10.1038/s41593-020-00758-5 |
| Datei: | https://www.nature.com/articles/s41593-020-00758-5 |