Publikationen im NUM

Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.

D. Thole, T. Ole Diesterhöft, S. Vogel, M. Greve, E. Bauer, S. Strathmann, C. Elsner, N. Kolbe and D. Krefting, "Relevant Aspects for Sustainable Open Source Pandemic Apps and Platform Deployment with Focus on Community Building", Stud Health Technol Inform, vol. 283, pp. 186—193, 2021.
DOI:10.3233/SHTI210580
K. Ansems, F. Grundeis, K. Dahms, A. Mikolajewska, V. Thieme, V. Piechotta, M. Metzendorf, M. Stegemann, C. Benstoem and F. Fichtner, "Remdesivir for the treatment of COVID‐19", Cochrane Database of Systematic Reviews, vol. 2021, no. 8, pp. CD014962, 2021.
DOI:10.1002/14651858.CD014962
D. Wurzer, P. Spielhagen, A. Siegmann, A. Gercekcioglu, J. Gorgass, S. Henze, Y. Kolar, F. Koneberg, S. Kukkonen, H. McGowan, S. Schmid-Eisinger, A. Steger, M. Dommasch, H. U. Haase, A. Müller, E. Martens, B. Haller, K. M. Huster and G. Schmidt, "Remote monitoring of COVID-19 positive high-risk patients in domestic isolation: A feasibility study", PLOS ONE, vol. 16, no. 9, pp. e0257095, 2021.
DOI:10.1371/journal.pone.0257095
Datei:https://doi.org/10.1371/journal.pone.0257095
S. Graf, L. Engelmann, O. Wölfler and D. Stahl, "Reopening the Bavarian State Opera Safely: Hygiene Strategies and Incidence of COVID-19 in Artistic Staff During Theater Season 2020/2021", Journal of Voice, 2021.
DOI:10.1016/j.jvoice.2021.11.012
Datei:https://doi.org/10.1016/j.jvoice.2021.11.012
M. Salholz-Hillel, P. Grabitz, M. Pugh-Jones, D. Strech and N. J. DeVito, "Results availability and timeliness of registered COVID-19 clinical trials: interim cross-sectional results from the DIRECCT study", BMJ Open, vol. 11, no. 11, pp. e053096, 2021.
DOI:10.1136/bmjopen-2021-053096
F. Nordsiek, E. Bodenschatz, G. Bagheri and et al, "Risk assessment for airborne disease transmission by poly-pathogen aerosols", PLOS ONE, 2021.
DOI:10.1371/journal.pone.0248004
M. Wunsch, D. Aschemeier, E. Hegera and et al, "Safe and effective pool testing for SARS-CoV-2 detection", J Clin Virol, vol. 145, 2021.
DOI:10.1016/j.jcv.2021.105018
S. Reis, M. Popp, B. Schmid, M. Stegemann, M. Metzendorf, P. Kranke, P. Meybohm and S. Weibel, "Safety and Efficacy of Intermediate- and Therapeutic-Dose Anticoagulation for Hospitalised Patients with COVID-19: A Systematic Review and Meta-Analysis", J Clin Med, vol. 11, no. 1, pp. 57, 2021.
DOI:10.3390/jcm11010057
D. Hillus and et al, "Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study", The Lancet Respiratory Medicine, 2021.
DOI:10.1016/S2213-2600(21)00357-X
[en] S. Pfefferle, T. Günther, R. Kobbe, M. Czech-Sioli, D. Nörz, R. Santer, J. Oh, S. Kluge, L. Oestereich, K. Peldschus, D. Indenbirken, J. Huang, A. Grundhoff, M. Aepfelbacher, J. K. Knobloch, M. Lütgehetmann and N. Fischer, "SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany", Clinical Microbiology and Infection, vol. 27, no. 1, pp. 130.e5—130.e8, Jan. 2021.
DOI:10.1016/j.cmi.2020.09.034
Datei:https://www.sciencedirect.com/science/article/pii/S1198743X20305875
M. Möckel, V. Corman, M. S. Stegemann and et al, "SARS-CoV-2 antigen rapid immunoassay for diagnosis of COVID-19 in the emergency department", Biomarker, vol. 26, no. 3, 2021.
DOI:10.1080/1354750X.2021.1876769
S. Deinhardt-Emmer, S. Bottcher, C. Haring, L. Giebeler, A. Henke and e. a. Zell, "SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction", J Virol, 2021.
D. Wendisch and et al, "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis", Cell, vol. 184, pp. 6243-6261.e27, 2021.
DOI:10.1016/j.cell.2021.11.033
D. Wendisch, O. Dietrich, T. Mari and et al, "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis", Cell, 2021.
DOI:10.1016/j.cell.2021.11.033
D. Wendisch, O. Dietrich, T. Mari, S. Stillfried, I. Ibarra, M. Mittermaier, C. Mache, R. Chua, R. Knoll, S. Timm and D. Stahl, "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis", Cell, vol. 184, no. 26, pp. 6243—6261.e27, 2021.
DOI:10.1016/j.cell.2021.11.033
D. Wendisch, O. Dietrich, T. Mari, S. Stillfried, I. L. Ibarra and e. a. Mittermaier, "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis", Cell, vol. 184, pp. 6243—6261.e6227, 2021.
DOI:10.1016/j.cell.2021.11.033
D. Wendisch, O. Dietrich, T. Mari, S. Von Stillfried, I. Ibarra, M. Mittermaier, C. Mache, R. Chua, R. Knoll, S. Timm, S. Brumhard, T. Kramer, R. Mothes, R. Bülow, J. Schulze, S. Djudjaj, F. Pott, J. Kazmierski, J. Radke, S. Baßler, B. Conrad, M. Landthaler, E. Wyler, D. Horst, S. Hippenstiel, A. Hocke, F. Heppner, A. Uhrig, C. V. García, S. Herold, S. Elezkurtaj, C. Thibeault, M. Witzenrath, N. Suttorp, C. Drosten, C. Goffinet, F. Kurth, J. L. Schultze, H. Radbruch, M. Ochs, R. Eils, H. C. Müller-Redetzky, A. E. Hauser, C. Conrad, T. Wolff, P. Boor, L. E. Sander, H. Zauber, A. Hiller, A. Pascual-Reguant, A. Leipold, F. Erhard, R. Geffers, P. Pergantis, A. Aschenbrenner, B. Sawitzki, C. Cochain, M. Luecken, F. Theis, M. Selbach, A. Saliba and F. Machleidt, "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.", Cell. 2021;184(26):6243-6261.e27., 2021.
J. Jansen, K. Reimer, J. Nagai and et al, "SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids", Cell Stem Cell, 2021.
DOI:10.1016/j.stem.2021.12.010
M. Hoffmann and et al, "SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization", Cell Reports, vol. 35, pp. 109017, 2021.
DOI:10.1016/j.celrep.2021.109017
J. J. Malin and et al, "SARS-CoV-2 neutralizing antibody treatment in COVID-19 patients with immunodeficiency due to B-cell non-Hodgkin lymphoma", Blood advances, 2021.
DOI:10.1182/bloodadvances.2021006655
T. Schwarz and et al, "SARS-CoV-2 Proteome-Wide Analysis Revealed Significant Epitope Signatures in COVID-19 Patients", Frontiers in immunology, vol. 12, pp. 629185, 2021.
DOI:10.3389/fimmu.2021.629185
S. Heinemann, A. Bludau, H. Kaba, P. Knolle, H. Grundmann and S. Scheithauer, "SARS-CoV-2 surveillance and testing: results of a survey from the Network of University Hospitals (NUM), B-FAST", GMS Hyg Infect Control, vol. 16, 2021.
DOI:10.3205/dgkh000402
S. Heinemann, A. Bludau, H. Kaba, P. Knolle, H. Grundmann and S. Scheithauer, "SARS-CoV-2 surveillance and testing: results of a survey from the Network of University Hospitals (NUM), B-FAST", GMS hygiene and infection control, vol. 16, pp. Doc31, 2021.
DOI:10.3205/dgkh000402
S. Heinemann, A. Bludau, H. Kaba, P. Knolle, H. Grundmann and S. Scheithauer, "SARS-CoV-2 surveillance and testing: results of a survey from the Network of University Hospitals (NUM), B-FAST", GMS Hyg Infect Control, vol. 16, 2021.
DOI:10.3205/dgkh000402
A. Köster, S. Heinemann, A. Bludau, H. Kaba, P. Knolle, H. Grundmann and S. Scheithauer, "SARS-CoV-2 surveillance and testing: results of a survey from the Network of University Hospitals (NUM), B-FAST. ", GMS Hygiene and Infection Control, 2021.
DOI:10.3205/dgkh000402
Datei:https://doi.org/10.3205/dgkh000402
M. Hoffmann and et al, "SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination", Cell Reports, vol. 36, pp. 109415, 2021.
DOI:10.1016/j.celrep.2021.109415
M. Hoffmann and et al, "SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies", Cell, vol. 184, pp. 2384-2393.e12, 2021.
DOI:10.1016/j.cell.2021.03.036
[Deutsch] B. Ondruschka, K. Püschel, P. Lange, I. Becker, G. Rieger-Ndakorerwa and A. S. Schröder, "SARS-CoV-2-assoziierte Hamburger Sterbefälle in der zweiten Pandemiewelle - Vergleich der bekannt gewordenen Todesfälle in den Gesundheitsämtern und der Rechtsmedizin", Archiv für Kriminologie, vol. 248, no. 5/6, pp. 180—187, 2021.
Datei:https://fis-uke.de/portal/de/publications/sarscov2assoziierte-hamburger-sterbefalle-in-der-zweiten-pandemiewelle—vergleich-der-bekannt-gewordenen-todesfalle-in-den-gesundheitsamtern-und-der-rechtsmedizin(c1c629dc-3719-4958-8c52-40ce6cad0c6b).html
L. Lohner, D. Fröb, C. Edler, A. S. Schröder, E. Dietz and B. Ondruschka, "SARS-CoV-2-assoziierte Todesfälle von erwachsenen Personen bis 50 Jahre: Eine retrospektive Auswertung der COVID-19-assoziierten Todesfälle im Jahr 2020 im Institut für Rechtsmedizin Hamburg, Deutschland [SARS-CoV-2-associated deaths in adult persons up to 50 years of age]", Rechtsmedizin (Berl), pp. 1-9, 2021.
N. Gassen, J. Papies, T. Bajaj, J. Emanuel, F. Dethloff and e. a. Chua, "SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals", Nat Commun, vol. 12, pp. 3818, 2021.
N. Kreuzberger, C. Hirsch, K. L. Chai, E. Tomlinson, Z. Khosravi, M. Popp, M. Neidhardt, V. Piechotta, S. Salomon, S. J. Valk, I. Monsef, C. Schmaderer, E. M. Wood, C. So-Osman, D. J. Roberts, Z. McQuilten, L. J. Estcourt and N. Skoetz, "SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19", Cochrane Database Syst Rev, vol. 9, no. 9, pp. CD013825, 2021.
DOI:10.1002/14651858.CD013825.pub2
N. Kreuzberger and et al, "SARS-CoV-2-neutralising monoclonal antibodies for treatment of COVID-19", Cochrane Database of Systematic Reviews, vol. 9, pp. CD013825, 2021.
DOI:10.1002/14651858.CD013825.pub2
C. Hirsch and et al, "SARS-CoV-2-neutralising monoclonal antibodies to prevent COVID-19", Cochrane Database of Systematic Reviews, 2021.
DOI:10.1002/14651858.CD014945
K. Schmidt and et al, "SARS-CoV-2-Seronegative Subjects Target CTL Epitopes in the SARS-CoV-2 Nucleoprotein Cross-Reactive to Common Cold Coronaviruses", Frontiers in immunology, vol. 12, pp. 627568, 2021.
DOI:10.3389/fimmu.2021.627568
D. Gornyk and et al, "SARS-CoV-2-Seroprävalenz in Deutschland. Eine bevölkerungsbezogene sequenzielle Studie in sieben Regionen", Dtsch Arztebl Int, vol. 118, pp. 824–831, 2021.
A. Klein, F. Langenwalder, F. Heinrich, K. Meißner, A. S. Schröder, K. Püschel, B. Ondruschka, M. Lütgehetmann and A. Heinemann, "SARS-CoV2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020 [SARS-CoV2 incidental findings among Hamburg deaths: an epidemiological monitoring during the dynamic infection event in spring 2020]", Rechtsmedizin (Berl), pp. 1-7, 2021.
D. Wolday, C. Denkinger and et al, "Scaled testing for COVID-19 needs community involvement", J Glob Health, vol. 11, 2021.
DOI:10.7189/jogh.11.03033
Datei:https://doi.org/10.7189/jogh.11.03033
S. Würstle, C. Spinner, F. Voit and D. Stahl, "Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing", Infection, vol. 49, no. 5, 2021.
DOI:10.1007/s15010-021-01614-9
Datei:https://doi.org/10.1007/s15010-021-01614-9
S. Würstle, C. D. Spinner, F. Voit and et al, "Self-sampling versus health care professional-guided swab collection for SARS-CoV-2 testing", Infection, vol. 49, no. 5, 2021.
DOI:10.1007/s15010-021-01614-9
J. Schmuck, N. Hiebel, M. Rabe, J. Schneider, Y. Erim, E. Morawa, L. Jerg-Bretzke, P. Beschoner, J. Hannemann, K. Weidner, S. Steudte-Schmiedgen, L. Radbruch, H. Brunsch and F. Geiser, "Sense of coherence, social support and religiosity as resources for medical personnel during the COVID-19 pandemic: A web-based survey among 4324 health care workers within the German Network University Medicine", PLOS ONE, vol. 16, no. 7, 2021.
DOI:10.1371/journal.pone.0255211
F. Poschenrieder, S. Meiler, M. Lubnow, F. Zeman, J. Rennert, G. Scharf, J. Schaible, C. Stroszczynski, M. Pfeifer and O. W. Hamer, "Severe COVID-19 pneumonia: Perfusion analysis in correlation with pulmonary embolism and vessel enlargement using dual-energy CT data", PloS one, vol. 16, no. 6, pp. e0252478, 2021.
DOI:10.1371/journal.pone.0252478
Datei:https://pubmed.ncbi.nlm.nih.gov/34101734/

Abstract:
Gas exchange in COVID-19 pneumonia is impaired and vessel obstruction has been suspected to cause ventilation-perfusion mismatch. Dual-energy CT (DECT) can depict pulmonary perfusion by regional assessment of iodine uptake. The purpose of this study was the analysis of pulmonary perfusion using dual-energy CT in a cohort of 27 consecutive patients with severe COVID-19 pneumonia. We retrospectively analyzed pulmonary perfusion with DECT in 27 consecutive patients (mean age 57 years, range 21-73; 19 men and 8 women) with severe COVID-19 pneumonia. Iodine uptake (IU) in regions-of-interest placed into normally aerated lung, ground-glass opacifications (GGO) and consolidations was measured using a dedicated postprocessing software. Vessel enlargement (VE) within opacifications and presence of pulmonary embolism (PE) was assessed by subjective analysis. Linear mixed models were used for statistical analyses. Compared to normally aerated lung 106/151 (70.2%) opacifications without upstream PE demonstrated an increased IU, 9/151 (6.0%) an equal IU and 36/151 (23.8%) a decreased IU. The estimated mean iodine uptake (EMIU) in opacifications without upstream PE (GGO 1.77 mg/mL; 95%-CI: 1.52-2.02; p = 0.011, consolidations 1.82 mg/mL; 95%-CI: 1.56-2.08, p = 0.006) was significantly higher compared to normal lung (1.22 mg/mL; 95%-CI: 0.95-1.49). In case of upstream PE, EMIU of opacifications (combined GGO and consolidations) was significantly decreased compared to normal lung (0.52 mg/mL; 95%-CI: -0.07-1.12; p = 0.043). The presence of VE in opacifications correlated significantly with iodine uptake (p<0.001). DECT revealed the opacifications in a subset of patients with severe COVID-19 pneumonia to be perfused non-uniformly with some being hypo- and others being hyperperfused. Mean iodine uptake in opacifications (both ground-glass and consolidation) was higher compared to normally aerated lung except for areas with upstream pulmonary embolism. Vessel enlargement correlated with iodine uptake: In summary, in a cohort of 27 consecutive patients with severe COVID-19 pneumonia, dual-energy CT demonstrated a wide range of iodine uptake in pulmonary ground-glass opacifications and consolidations as a surrogate marker for hypo- and hyperperfusion compared to normally aerated lung. Applying DECT to determine which pathophysiology is predominant might help to tailor therapy to the individual patient´s needs.
F. Steinbeis, C. Thibeault, F. Doellinger, R. Ring, M. Mittermaier, C. Ruwwe-Glösenkamp, P. Knape, H. Meyer, L. Lippert and D. Stahl, "Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months", Respir Med, vol. 191, pp. 106709, 2021.
DOI:10.1016/j.rmed.2021.106709
F. Günl, A. Mecate-Zambrano, S. Rehländer, S. Hinse, S. Ludwig and L. Brunotte, "Shooting at a Moving Target-Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development", Vaccines (Basel), vol. 9, 2021.
D. Fischer and et al, "Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'", Nature Communications, vol. 12, pp. 4515, 2021.
DOI:10.1038/s41467-021-24730-4
A. Wulff, C. Baier, M. Marschollek and et al, "SmICS: Eine smarte Lösung zur automatisierten Ausbruchserkennung im Krankenhaus", Gesundhyte, vol. 14, 2021.
Datei:pdfhttps://www.systembiologie.de/lw_resource/datapool/systemfiles/elements/files/D344CA9772B73013E0537E695E8653F9/live/document/PTJ-009_gesundhyte_14_2021_dt_WEB-ISSN_2702-2552_211215_WEB.pdf
C. Schug, E. Morawa, F. Geiser, N. Hiebel, P. Beschoner, L. Jerg-Bretzke, K. Weidner, S. Steudte-Schmiedgen, A. Borho, M. Lieb and Y. Erim, "Social Support and Optimism as Protective Factors for Mental Health among 7765 Healthcare Workers in Germany during the COVID-19 Pandemic: Results of the VOICE Study", International Journal of Environmental Research and Public Health, vol. 18, no. 7, 2021.
DOI:10.3390/ijerph18073827
Datei:https://doi.org/10.3390/ijerph18073827
N. Dragano, J. Hoebel, B. Wachtler, M. Diercke, T. Lunau and M. Wahrendorf, "Soziale Ungleichheit in der regionalen Ausbreitung von SARS-CoV-2", Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, vol. 64, pp. 1116—1124, 2021.
DOI:10.1007/s00103-021-03387-w
R. Rubio-Acero, J. Beyerl, M. Muenchhoff, M. Roth, N. Castelletti, I. Paunovic, K. Radon, B. Springer, C. Nagel, B. Boehm, M. Böhmer, A. Graf, H. Blum, S. Krebs, O. Keppler, A. Osterman, Z. Khan, M. Hoelscher and A. Wieser, "Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience", The Science of the total environment, vol. 797, pp. 149031, 2021.
DOI:10.1016/j.scitotenv.2021.149031
R. Rubio-Acero, J. Beyerl, M. Muenchhoff, M. S. Roth, N. Castelletti, I. Paunovic, K. Radon, B. Springer, C. Nagel, B. Boehm, M. M. Böhmer, A. Graf, H. Blum, S. Krebs, O. T. Keppler, A. Osterman, Z. N. Khan, M. Hoelscher, A. Wieser and KoCo19-Study Group, "Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich - One year of experience", Science of The Total Environment, 2021.
DOI:10.1016/j.scitotenv.2021.149031
Datei:https://doi.org/10.1016/j.scitotenv.2021.149031
R. Rubio-Acero, J. Beyerl, M. Muenchhoff and et al, "Spatially resolved qualified sewage spot sampling to track SARS-CoV-2 dynamics in Munich: One year of experience", Sci Total Environ, vol. 797, 2021.
DOI:10.1016/j.scitotenv.2021.149031