Publikationen im NUM

Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.

T. Houwaart, S. Belhaj, E. Tawalbeh, D. Nagels, Y. Fröhlich, P. Finzer, P. Ciruela, A. Sabrià, M. Herrero, C. Andrés, A. Antón, A. Benmoumene, D. Asskali, H. Haidar, J. von Dahlen, J. Nicolai, M. Stiller, J. Blum, C. Lange, C. Adelmann, B. Schroer, U. Osmers, C. Grice, P. Kirfel, H. Jomaa, D. Strelow, L. Hülse, M. Pigulla, P. Kreuzer, A. Tyshaieva, J. Weber, T. Wienemann, M. Kohns Vasconcelos, K. Hoffmann, N. Lübke, S. Hauka, M. Andree, C. Scholz, N. Jazmati, K. Göbels, R. Zotz, K. Pfeffer, J. Timm, L. Ehlkes, A. Walker, A. Dilthey and German COVID-19 OMICS Initiative (DeCOI), "Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021", Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 27, no. 43, 2022.
DOI:10.2807/1560-7917.ES.2022.27.43.2101089
H. Torsten, B. Samir, T. Emran, N. Dirk, F. Yara, F. Patrick, C. Pilar, S. Aurora, H. Mercè, A. Cristina, A. Andrés, B. Assia, A. Dounia, H. Hussein, Janina, N. Jessica, S. Mygg, B. Jacqueline, L. Christian, A. Carla, S. Britta, O. Ute, G. Christiane, K. P. P., J. Hassan, S. Daniel, H. Lisanna, P. Moritz, K. Pascal, T. Alona, W. Jonas, W. Tobias, K. V. Malte, H. Katrin, L. Nadine, H. Sandra, A. Marcel, S. C. Juergen, J. Nathalie, G. Klaus, Z. Rainer, P. Klaus, T. Joerg, E. Lutz, W. Andreas, D. A. T. and G. C. O. I. (DeCOI), "Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021.", Eurosurveillance, 2022.
DOI:10.2807/1560-7917.ES.2022.27.43.2101089
Datei:https://doi.org/10.2807/1560-7917.ES.2022.27.43.2101089
A. Müller, H. Haneke, V. Kirchberger, G. Mastella, M. Dommasch, U. Merle, O. Heinze, A. Siegmann, C. Spinner, A. Buiatti, K. Laugwitz, G. Schmidt and E. Martens, "Integration of mobile sensors in a telemedicine hospital system: Remote-monitoring in COVID-19 patients", Journal of Public Health, vol. 30, no. 1, pp. 93—97, 2022.
DOI:10.1007/s10389-021-01655-2
M. Kantauskaite and et al, "Intensity of mycophenolate mofetil treatment is associated with an impaired immune response to SARS-CoV-2 vaccination in kidney transplant recipients", American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 22, pp. 634–639, 2022.
DOI:10.1111/ajt.16851
Oorschot and D. Stahl, "Interaktive Homepage für Trauernde in Pandemiezeiten", Schmerz, Nervenarzt, Forum DKG, Urologe, Onkologe, 2022.
P. Dönges, J. Wagner, S. Contreras, E. N. Iftekhar, S. Bauer, S. B. Mohr, J. Dehning, A. C. Valdez, M. Kretzschmar, M. Mäs, K. Nagel and V. Priesemann, "Interplay Between Risk Perception, Behavior, and COVID-19 Spread", Frontiers in Physics, vol. 10, pp. 842180, 2022.
DOI:10.3389/fphy.2022.842180
S. Stillfried, R. Bülow, R. Röhrig, P. Meybohm and P. Boor, "Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report", Critical care (London, England), vol. 26, pp. 83, 2022.
DOI:10.1186/s13054-022-03945-x
B. Pauli, J. Strupp, K. Schloesser and D. Stahl, "It’s like standing in front of a prison fence – Dying during the SARS-CoV2 pandemic: A qualitative study of bereaved relatives’ experiences", Palliative Medicine, 2022.
DOI:10.1177/02692163221076355
S. Krishnaratne, H. Littlecott, K. Sell, J. Burns, J. E. Rabe, J. M. Stratil, T. Litwin, C. Kreutz, M. Coenen, K. Geffert, A. H. Boger, A. Movsisyan, S. Kratzer, C. Klinger, K. Wabnitz, B. Strahwald, B. Verboom, E. Rehfuess, R. L. Biallas, C. Jung-Sievers, S. Voss and L. M. Pfadenhauer, "Measures implemented in the school setting to contain the COVID-19 pandemic: a rapid review", Cochrane Database of Systematic Reviews, vol. 2022, pp. CD015029, 2022.
DOI:10.1002/14651858.CD015029
[eng] M. Ackermann and D. D. Jonigk, "Microvascular placental alterations in maternal COVID-19", American Journal of Obstetrics and Gynecology, vol. 226, no. 1, pp. 135—136, Jan. 2022.
DOI:10.1016/j.ajog.2021.06.098
J. Schwartz, M. C. Reuters, M. Schallenburger, S. Meier, C. Roch, L. Werner, B. Oorschot and M. Neukirchen, "Modelle guter Praxis: Alleine sterben ist ethisch nicht vertretbar", Praxis Palliative Care, vol. 54, pp. 29-36, 2022.
N. Wanner, G. Andrieux, P. Badia-i-Mompel and et al, "Molecular consequences of SARS-CoV-2 liver tropism", Nat Metab, vol. 4, pp. 310-319, 2022.
DOI:10.1038/s42255-022-00552-6
H. Gruell and et al, "mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant", Nature Medicine, 2022.
DOI:10.1038/s41591-021-01676-0
Z. Liu and et al, "Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19", Frontiers in immunology, vol. 13, pp. 838132, 2022.
DOI:10.3389/fimmu.2022.838132
T. Illig, "NAPKON- Eine Erfolgsgeschichte", Plenarvortrag, Nationales Biobanken Symposium, 2022.
C. Bausewein, F. Hodiamont, N. Berges, A. Ullrich, C. Gerlach, K. Oechsle, B. Pauli, J. Weber, S. Stiel, N. Schneider and D. Stahl, "National strategy for palliative care of severely ill and dying people and their relatives in pandemics (PallPan) in Germany - study protocol of a mixed-methods project", BMC palliative care, vol. 21, no. 1, pp. 10, 2022.
DOI:10.1186/s12904-021-00898-w
F. Heinrich, K. Roedl, D. Jarczak and et al, "New Insights in the Occurrence of Venous Thromboembolism in Critically Ill Patients with COVID-19—A Large Postmortem and Clinical Analysis", Viruses, vol. 14, pp. 811, 2022.
DOI:10.3390/v14040811
P. Arora and et al, "No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2", Cellular & Molecular Immunology, 2022.
DOI:10.1038/s41423-021-00811-8
M. S. Ercanoglu and et al, "No substantial preexisting B cell immunity against SARS-CoV-2 in healthy adults", iScience, vol. 25, pp. 103951, 2022.
DOI:10.1016/j.isci.2022.103951
S. Zellmer, E. Bachmann, A. Muzalyova and et al, "One year of the COVID-19 pandemic in dental medical facilities in Germany: A questionnaire-based analysis", Int J Environ Res Public Health, vol. 19, no. 1, 2022.
DOI:10.3390/ijerph19010175
D. Jonigk, C. Werlein and et al, "Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?", Virchows Arch, 2022.
DOI:10.1007/s00428-022-03319-2
Oorschot and D. Stahl, "PallPan Richtig handeln in der Betreuung Schwerkranker und Sterbender in Pandemiezeiten", Der Ophthalmologe, 2022.
J. Ebler, P. Ebert, W. Clarke, T. Rausch, P. Audano, T. Houwaart, Y. Mao, J. Korbel, E. Eichler, M. Zody, A. Dilthey and T. Marschall, "Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes", Nature genetics, vol. 54, no. 4, pp. 518—525, 2022.
DOI:10.1038/s41588-022-01043-w
J. Ebler, P. Ebert, W. E. Clarke, T. Rausch, P. A. Audano, T. Houwaart, Y. Mao, J. O. Korbel, E. E. Eichler, M. C. Zody, A. T. Dilthey and T. Marschall, "Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes", Nature Genetics, 2022.
DOI:10.1038/s41588-022-01043-w
Datei:https://doi.org/10.1038/s41588-022-01043-w
F. Heinrich, A. Schröder, A. Gerberding and et al, "Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths", Emerg Infect Dis, vol. 28, pp. 244-247, 2022.
DOI:10.3201/eid2801.211749
[eng] F. Heinrich, A. S. Schröder, A. Gerberding, M. Gerling, F. Langenwalder, P. Lange, A. Heinemann, E. Bibiza-Freiwald, D. S. Nörz, M. Aepfelbacher, S. Pfefferle, B. Ondruschka and M. Lütgehetmann, "Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths", Emerging Infectious Diseases, vol. 28, no. 1, pp. 244—247, Jan. 2022.
DOI:10.3201/eid2801.211749
T. Schwarz and et al, "Preserved T cell responses to SARS-CoV-2 in anti-CD20 treated multiple sclerosis", Multiple Sclerosis Journal, 2022.
DOI:10.1101/2021.10.11.21264694
H. Gorji, N. Stauffer, I. Lunati and et al, "Projection of healthcare demand in Germany and Switzerland urged by omicron wave (January-March 2022)", MedRxiv, 2022.
DOI:10.1101/2022.01.24.22269676
C. Dächert, M. Muenchhoff, A. Graf and et al, "Rapid and sensitive identification of omicron by variant-specific PCR and nanopore sequencing: paradigm for diagnostics of emerging SARS-CoV-2 variants", Med Microbiol Immunol, vol. 211, no. 1, 2022.
DOI:10.1007/s00430-022-00728-7
Datei:https://doi.org/10.1007/s00430-022-00728-7
M. Zickler, S. Stanelle-Bertram, S. Ehret and et al, "Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans", Cell Metab, vol. 34, pp. 1-2, 2022.
DOI:10.1016/j.cmet.2021.12.002
[eng] M. Zickler, S. Stanelle-Bertram, S. Ehret, F. Heinrich, P. Lange, B. Schaumburg, N. M. Kouassi, S. Beck, M. Y. Jaeckstein, O. Mann, S. Krasemann, M. Schroeder, D. Jarczak, A. Nierhaus, S. Kluge, M. Peschka, H. Schlüter, T. Renné, K. Pueschel, A. Kloetgen, L. Scheja, B. Ondruschka, J. Heeren and G. Gabriel, "Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans", Cell Metabolism, vol. 34, no. 1, pp. 1—2, Jan. 2022.
DOI:10.1016/j.cmet.2021.12.002

Abstract:
Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.
M. Neidhardt, S. Gerlach, R. Mieling and et al, "Robotic Tissue Sampling for Safe Post-Mortem Biopsy in Infectious Corpses", IEEE Trans. Med. Robot. Bionics, vol. 4, pp. 94-105, 2022.
DOI:10.1109/TMRB.2022.3146440
S. Hammerschmidt, C. Thurm, B. Bošnjak and et al, "Robust induction of neutralizing antibodies against the SARS‐CoV‐2 Delta variant after homologous Spikevax or heterologous Vaxzevria‐Spikevax vaccination", Eur J Immunol, vol. 52, no. 2, 2022.
DOI:10.1002/eji.202149645
S. Momsen Reincke and et al, "SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies", Science (New York, N.Y.), 2022.
DOI:10.1126/science.abm5835
E. Layer, S. Hoehl, M. Widera, D. Bojkova, T. Westphal, R. Gottschalk, B. Boeddinghaus, J. Schork, S. Ciesek and U. Goetsch, "SARS-CoV-2 screening strategies for returning international travellers: Evaluation of a rapid antigen test approach", International Journal of Infectious Diseases, vol. 118, pp. 126—131, 2022.
DOI:10.1016/j.ijid.2022.02.045
I. Backhaus, D. Hermsen, J. Timm, F. Boege, N. Lübke, T. Degode, K. Göbels and N. Dragano, "SARS-CoV-2 seroprevalence and determinants of infection in young adults: A population-based seroepidemiological study", Public Health, 2022.
DOI:https://doi.org/10.1016/j.puhe.2022.03.009
P. Arora and et al, "SARS-CoV-2 variants C.1.2 and B.1.621 (Mu) partially evade neutralization by antibodies elicited upon infection or vaccination", Cell Reports, vol. 39, pp. 110754, 2022.
DOI:10.1016/j.celrep.2022.110754
F. Steinbeis, C. Thibeault, F. Doellinger, R. Ring, M. Mittermaier, C. Ruwwe-Glösenkamp, P. Knape, H. Meyer, L. Lippert, E. Helbig, B. Temmesfeld, N. Suttorp, L. E. Sander, F. Kurth, T. Penzkofer, M. Witzenrath, T. Zoller and D. Grund, "Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.", Respir Med. 2022;191:106709., 2022.
F. Steinbeis, C. Thibeault, F. Doellinger, R. M. Ring, M. Mittermaier, C. Ruwwe-Glösenkamp, F. Alius, P. Knape, H. Meyer, L. J. Lippert, E. T. Helbig, D. Grund, B. Temmesfeld-Wollbrück, N. Suttorp, L. E. Sander, F. Kurth, T. Penzkofer, M. Witzenrath and T. Zoller, "Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.", Respiratory medicine, Jan. 2022.
DOI:10.1016/j.rmed.2021.106709

Abstract:
Prospektive und longitudinale Daten zur Lungenverletzung über ein Jahr nach akuter Coronavirus-Krankheit 2019 (COVID-19) sind spärlich. Die Patienten mit akutem COVID-19 wurden in ein laufendes, prospektives Beobachtungsstudium eingeschrieben und 6 Wochen, 3, 6 und 12 Monate nach Beginn der Symptome von COVID-19 untersucht. Chest CT-Scans, Lungenfunktion und Symptome, die von St. Georges Respiratory Questionnaire bewertet wurden, wurden verwendet, um Atembeschränkungen zu bewerten. Die Patienten wurden nach Schwere der akuten COVID-19 gestreut. Das mittlere Alter aller Patienten betrug 57 Jahre, 37,8% waren weiblich. Höheres Alter, männliches Geschlecht und höheres BMI wurden mit akuter COVID-19 Schwere verbunden (p < 0,0001, 0,001 bzw. 0,004). Auch die Lungenbeschränkung und die verringerte Kohlenmonoxiddiffusionskapazität war mit der Krankheitsschwere verbunden. Bei Patienten mit eingeschränkter und beeinträchtigter Diffusionskapazität verbesserte sich FVC über 12 Monate von 61,32 bis 71,82, DC von 68,92 bis 76,95, D<sub>LCO</sub> von 60,18 bis 68,98 und K<sub>CO</sub> von 81,28 bis 87,80 (prozentige prognostizierte Werte; p = 0,002, 0,045, 0,0002 und 0,0005). Der CT-Score der Lungenbeteiligung in der akuten Phase war mit einer Restriktion und Verringerung der Diffusionskapazität im Anschluss verbunden. Atemwegserkrankungen verbesserten sich bei Patienten in höheren Schweregruppen während der Folge, nicht aber bei Patienten mit zunächst milder Erkrankung. Schwere des Atemversagens während der COVID-19 korreliert mit dem Grad der Lungenfunktion Beeinträchtigung und Atmungsqualität des Lebens im Jahr nach akuter Infektion.
D. Medenwald, T. Brunner, H. Christiansen and et al, "Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient data", Strahlenther Onkol, vol. 198, no. 4, pp. 334—345, 2022.
DOI:10.1007/s00066-021-01883-1
C. Koll, S. Hopff, T. Meurers, C. Lee, M. Kohls, C. Stellbrink, C. Thibeault, L. Reinke, S. Steinbrecher, S. Schreiber and D. Stahl, "Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients", Sci Data, vol. 9, no. 1, pp. 776, 2022.
DOI:10.1038/s41597-022-01669-9
C. Koll, S. Hopff and T. Meurers, "Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients.", Sci Data 9, 776, 2022.
DOI:10.1038/s41597-022-01669-9
M. Mayer, S. Zellmer, J. Zenk and et al, "Status quo after one year of COVID-19 pandemic in otolaryngological hospital-based departments and private practices in Germany", Eur Arch Otorhinolaryngol, vol. 279, no. 2, 2022.
DOI:10.1007/s00405-021-06992-2
H. Hoven, N. Dragano, P. Angerer, C. Apfelbacher, I. Backhaus, B. Hoffmann, A. Icks, S. Wilm, F. Fangerau and F. Söhner, "Striving for health equality: The importance of social determinants of health and ethical considerations in pandemic preparedness planning", International Journal of Public Health, vol. 67, pp. 1604542, 2022.
DOI:10.3389/ijph.2022.1604542
L. Peter and et al, "Tacrolimus-resistant SARS-CoV-2-specific T cell products to prevent and treat severe COVID-19 in immunosuppressed patients", Molecular therapy. Methods & clinical development, vol. 25, pp. 52–73, 2022.
DOI:10.1016/j.omtm.2022.02.012
T. Czypionka, E. N. Iftekhar, B. Prainsack, V. Priesemann, S. Bauer, A. C. Valdez, S. Cuschieri, E. Glaab, E. Grill, J. Krutzinna, C. Lionis, H. Machado, C. Martins, G. N. Pavlakis, M. Perc, E. Petelos, M. Pickersgill, A. Skupin, E. Schernhammer, E. Szczurek, S. Tsiodras, P. Willeit and P. Wilmes, "The benefits, costs and feasibility of a low incidence COVID-19 strategy", The Lancet Regional Health-Europe, vol. 13, pp. 100294, 2022.
DOI:10.1016/j.lanepe.2021.100294
S. Krasemann, U. Haferkamp, S. Pfefferle and et al, "The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2", Stem Cell Reports, vol. 17, pp. 307-320, 2022.
DOI:10.1016/j.stemcr.2021.12.011
P. Tafforeau, W. Wagner and et al, "The Bronchial Circulation in COVID-19 Pneumonia", Am J Respir Crit Care Med, vol. 205, pp. 121-125, 2022.
DOI:10.1164/rccm.202103-0594IM
[eng] M. Ackermann, P. Tafforeau, W. L. Wagner, C. L. Walsh, C. Werlein, M. P. Kühnel, F. P. Länger, C. Disney, A. J. Bodey, A. Bellier, S. E. Verleden, P. D. Lee, S. J. Mentzer and D. D. Jonigk, "The Bronchial Circulation in COVID-19 Pneumonia", American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 1, pp. 121—125, Jan. 2022.
DOI:10.1164/rccm.202103-0594IM
P. Borusiak, Y. Mazheika, S. Bauer, E. Haberlandt, I. Krois, C. Fricke, L. Simon, P. Beschoner, L. Jerg-Bretzke, F. Geiser, N. Hiebel, K. Weidner, E. Morawa and Y. Erim, "The impact of the COVID-19 pandemic on pediatric developmental services: a cross-sectional study on overall burden and mental health status", Arch Public Health, vol. 80, no. 1, pp. 113, 2022.