Publikationen aus Organo-Strat
37.
P. Georg,
R. Astaburuaga-García,
L. Bonaguro,
S. Brumhard,
L. Michalick and
e. a. Lippert,
"Complement activation induces excessive T cell cytotoxicity in severe COVID-19",
Cell,
vol. 185,
pp. 493—512.e425,
2022.
36.
M. Pietzner,
R. L. Chua,
E. Wheeler,
K. Jechow,
H. Radbruch and
e. a. Trump,
"ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19",
medRxiv,
2022.
| DOI: | 10.1101/2022.01.17.22269283 |
35.
K. Hönzke,
B. Obermayer,
C. Mache,
D. Fathykova,
M. Kessler and
e. a. Dökel,
"Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages",
Eur Respir J,
vol. 60,
no. 6,
pp. 2102725,
2022.
| DOI: | 10.1183/13993003.02725-2021 |
34.
A. Schreiber,
D. Viemann,
J. Schöning,
S. Schloer,
A. Mecate Zambrano and
e. a. Brunotte,
"The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses",
Cell Mol Life Sci,
vol. 79,
pp. 65,
2022.
| DOI: | 10.1007/s00018-021-03917-x |
33.
Z. Wang,
A. Cryar,
O. Lemke,
D. Ludwig,
P. Tober-Lau and
e. a. Helbig,
"A multiplex protein panel assay determines disease severity and is prognostic about outcome in COVID-19 patients",
medRxiv,
2021.
| DOI: | 10.1101/2021.12.03.21267253 |
32.
V. Demichev,
P. Tober-Lau,
O. Lemke,
T. Nazarenko,
C. Thibeault and
e. a. Whitwell,
"A time-resolved proteomic and prognostic map of COVID-19",
Cell Syst,
vol. 12,
pp. 780—+,
2021.
31.
M. L. Stanifer and
S. Boulant,
"Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions",
JoVE,
no. 166,
pp. e62857,
2021.
| DOI: | 10.3791/62857 |
30.
J. Schulze,
C. Mache,
A. Balazs,
D. Frey,
D. Niemeyer and
e. a. Olze,
"Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses",
J Infect Dis,
2021.
| DOI: | 10.1093/infdis/jiab489 |
29.
T. Aschman,
J. Schneider,
S. Greuel,
J. Meinhardt,
S. Streit and
e. a. Goebel,
"Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died",
JAMA Neurol,
vol. 78,
pp. 948—960,
2021.
28.
S. Kumar,
D. Çalışkan,
J. Janowski,
A. Faist,
B. Conrad and
e. a. Lange,
"Beyond Vaccines: Clinical Status of Prospective COVID-19 Therapeutics",
Front Immunol,
vol. 12,
pp. 752227,
2021.
27.
M. Ochs,
S. Timm,
S. Elezkurtaj,
D. Horst,
J. Meinhardt and
e. a. Heppner,
"Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient",
Eur Respir J,
vol. 57,
2021.
| DOI: | 10.1183/13993003.02311-2020 |
26.
L. Brunotte,
S. Zheng,
A. Mecate-Zambrano,
J. Tang,
S. Ludwig and
e. a. Rescher,
"Combination Therapy with Fluoxetine and the Nucleoside Analog GS-441524 Exerts Synergistic Antiviral Effects against Different SARS-CoV-2 Variants In Vitro",
Pharmaceutics,
vol. 13,
2021.
25.
N. Ritschel,
H. Radbruch,
C. Herden,
N. Schneider,
C. Dittmayer and
e. a. Franz,
"COVID-19 and the central and peripheral nervous system",
Pathologe,
vol. 42,
pp. 172—182,
2021.
| DOI: | 10.1007/s00292-021-00923-w |
24.
P. Adhikary,
Q. Ul Ain,
A. Hocke and
S. Hedtrich,
"COVID-19 highlights the model dilemma in biomedical research",
Nat Rev Mater,
pp. 1—3,
2021.
23.
L. Loyal,
J. Braun,
L. Henze,
B. Kruse,
M. Dingeldey and
e. a. Reimer,
"Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination",
Science,
2021.
22.
S. Deinhardt-Emmer,
D. Wittschieber,
J. Sanft,
S. Kleemann,
S. Elschner and
e. a. Haupt,
"Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage",
Elife,
vol. 10,
2021.
21.
A. Gruber,
T. Firsching,
J. Trimpert and
K. Dietert,
"Hamster models of COVID-19 pneumonia reviewed: How human can they be?",
Vet Pathol,
2021.
20.
M. Lehmann,
K. Allers,
C. Heldt,
J. Meinhardt,
F. Schmidt and
e. a. Rodriguez-Sillke,
"Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8(+) T cells",
Mucosal Immunol,
vol. 14,
pp. 1381—1392,
2021.
19.
S. Trump,
S. Lukassen,
S. M. Anker,
R. L. Chua,
J. Liebig and
e. a. Thurmann,
"Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19",
Nat Biotechnol,
vol. 39,
pp. 705—716,
2021.
| DOI: | 10.1038/s41587-021-00937-2 |
18.
E. Wyler,
J. M. Adler,
K. Eschke,
G. T. Alves,
S. Peidli and
e. a. Pott,
"Insights into standards of care – dexamethasone and antibodies against COVID-19 in hamster models",
bioRxiv,
2021.
| DOI: | 10.1101/2021.12.17.473180 |
17.
S. Schroeder,
F. Pott,
D. Niemeyer,
T. Veith,
A. Richter and
e. a. Muth,
"Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics",
Lancet Microbe,
vol. 2,
pp. e210—e218,
2021.
| DOI: | 10.1016/S2666-5247(21)00069-0 |
16.
P. Laise,
M. Stanifer,
G. Bosker,
X. Sun,
S. Triana and
e. a. Doldan,
"Network-based identification and pharmacological targeting of host cell master regulators induced by SARS-CoV-2 infection",
bioRxiv,
2021.
| DOI: | 10.1101/2021.07.03.451001 |
15.
C. Aguilar,
M. Silva,
M. Saraiva,
M. Neyazi,
I. Olsson and
S. Bartfeld,
"Organoids as host models for infection biology - a review of methods",
Exp Mol Med,
vol. 53,
pp. 1471—1482,
2021.
14.
L. Michalick,
S. Weidenfeld,
B. Grimmer,
D. Fatykhova,
P. D. Solymosi,
F. Behrens,
M. Dohmen,
M. Brack,
S. Schulz,
E. Thomasch,
S. Simmons,
H. Müller-Redetzky,
N. Suttorp,
F. Kurth,
J. Neudecker,
M. Toennies,
T. T. Bauer,
S. Eggeling,
V. M. Corman,
A. C. Hocke,
M. Witzenrath,
S. Hippenstiel and
W. M. Kuebler,
"Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure",
Eur Respir J,
vol. 57,
no. 3,
pp. 2002384,
2021.
| DOI: | 10.1183/13993003.02384-2020 |
13.
D. Niemeyer,
S. Schroeder,
K. Friedmann,
F. Weege,
J. Trimpert and
e. a. Richter,
"Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line",
bioRxiv,
2021.
| DOI: | 10.1101/2021.10.20.465121 |
12.
S. Deinhardt-Emmer,
S. Bottcher,
C. Haring,
L. Giebeler,
A. Henke and
e. a. Zell,
"SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction",
J Virol,
2021.
11.
D. Wendisch,
O. Dietrich,
T. Mari,
S. Stillfried,
I. L. Ibarra and
e. a. Mittermaier,
"SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis",
Cell,
vol. 184,
pp. 6243—6261.e6227,
2021.
| DOI: | 10.1016/j.cell.2021.11.033 |
10.
N. Gassen,
J. Papies,
T. Bajaj,
J. Emanuel,
F. Dethloff and
e. a. Chua,
"SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals",
Nat Commun,
vol. 12,
pp. 3818,
2021.
9.
F. Günl,
A. Mecate-Zambrano,
S. Rehländer,
S. Hinse,
S. Ludwig and
L. Brunotte,
"Shooting at a Moving Target-Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine Development",
Vaccines (Basel),
vol. 9,
2021.
8.
G. Nouailles,
E. Wyler,
P. Pennitz,
D. Postmus,
D. Vladimirova and
e. a. Kazmierski,
"Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19",
Nat Commun,
vol. 12,
pp. 4869,
2021.
| DOI: | 10.1038/s41467-021-25030-7 |
7.
C. Ramirez Alvarez,
C. Kee,
A. K. Sharma,
L. Thomas,
F. I. Schmidt and
e. a. Stanifer,
"The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated with disease severity",
PLOS Pathogens,
vol. 17,
no. 5,
pp. e1009687,
2021.
| DOI: | 10.1371/journal.ppat.1009687 |
6.
F. Hornung,
J. Rogal,
P. Loskill,
B. Löffler and
S. Deinhardt-Emmer,
"The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections",
Int J Mol Sci,
vol. 22,
2021.
5.
K. Kitazawa,
S. Deinhardt-Emmer,
T. Inomata,
S. Deshpande and
C. Sotozono,
"The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies",
Cells,
vol. 10,
2021.
4.
E. Wyler,
K. Mosbauer,
V. Franke,
A. Diag,
L. T. Gottula and
e. a. Arsie,
"Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy",
iScience,
vol. 24,
pp. 102151,
2021.
| DOI: | 10.1016/j.isci.2021.102151 |
3.
S. Schuster,
J. Lisack,
I. Subota,
H. Zimmermann,
C. Reuter and
e. a. Mueller,
"Unexpected plasticity in the life cycle of Trypanosoma brucei",
Elife,
vol. 10,
2021.
| DOI: | 10.7554/eLife.62090 |
2.
M. Witkowski,
C. Tizian,
M. Ferreira-Gomes,
D. Niemeyer,
T. C. Jones and
e. a. Heinrich,
"Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells",
Nature,
2021.
| DOI: | 10.1038/s41586-021-03859-9 |
1.
A. Gruber,
N. Osterrieder,
L. Bertzbach,
D. Vladimirova,
S. Greuel and
e. a. Ihlow,
"Standardization of Reporting Criteria for Lung Pathology in SARS-CoV-2–infected Hamsters: What Matters?",
Am. J. Respir. Cell Mol. Biol.,
vol. 63,
pp. 856—859,
2020.