Publikationen im NUM

Hier finden Sie eine Liste der Publikationen, die im Zusammenhang mit dem Netzwerk Universitätsmedizin in der ersten und zweiten Förderphase entstanden sind.

P. R. Wratil, M. Stern, A. Priller and et al, "Three exposures to the spike protein of SARS-CoV-2 by either infection or vaccination elicit superior neutralizing immunity to all variants of concern", Nat Med, 2022.
DOI:10.1038/s41591-022-01715-4
M. Voigtlaender, C. Edler, M. Gerling, J. Schädler, B. Ondruschka, A. S. Schröder, J. Sperhake, S. Ehrhardt, L. Wang, M. Haddad, V. Kiencke, T. Renné, K. Roedl, S. Kluge, D. Wichmann and F. Länger, "Thromboembolic events in deceased patients with proven SARS-CoV-2 infection: Frequency, characteristics and risk factors", Thrombosis Research, vol. 218, pp. 171—176, Okt. 2022.
DOI:10.1016/j.thromres.2022.08.021
Datei:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420077/

Abstract:
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[eng] J. C. Kamp, L. Neubert, M. Ackermann, H. Stark, C. Werlein, J. Fuge, A. Haverich, A. Tzankov, K. Steinestel, J. Friemann, P. Boor, K. Junker, M. M. Hoeper, T. Welte, F. Laenger, M. P. Kuehnel and D. D. Jonigk, "Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19", International Journal of Molecular Sciences, vol. 23, no. 3, pp. 1583, Jan. 2022.
DOI:10.3390/ijms23031583

Abstract:
(1) Background: In COVID-19 survivors there is an increased prevalence of pulmonary fibrosis of which the underlying molecular mechanisms are poorly understood; (2) Methods: In this multicentric study, n = 12 patients who succumbed to COVID-19 due to progressive respiratory failure were assigned to an early and late group (death within ≤7 and \textgreater7 days of hospitalization, respectively) and compared to n = 11 healthy controls; mRNA and protein expression as well as biological pathway analysis were performed to gain insights into the evolution of pulmonary fibrogenesis in COVID-19; (3) Results: Median duration of hospitalization until death was 3 (IQR25-75, 3-3.75) and 14 (12.5-14) days in the early and late group, respectively. Fifty-eight out of 770 analyzed genes showed a significantly altered expression signature in COVID-19 compared to controls in a time-dependent manner. The entire study group showed an increased expression of BST2 and IL1R1, independent of hospitalization time. In the early group there was increased activity of inflammation-related genes and pathways, while fibrosis-related genes (particularly PDGFRB) and pathways dominated in the late group; (4) Conclusions: After the first week of hospitalization, there is a shift from pro-inflammatory to fibrogenic activity in severe COVID-19. IL1R1 and PDGFRB may serve as potential therapeutic targets in future studies.
J. Kamp, L. Neubert, M. Ackermann and et al, "Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19", Int J Mol Sci, vol. 23, 2022.
DOI:10.3390/ijms23031583
A. Wulff, P. Biermann, T. Landesberger, T. Baumgartl, C. Schmidt, A. Y. Alhaji, K. Schick, P. Waldstein, Y. Zhu, D. Krefting, S. Scheithauer and M. Marschollek, "Tracing COVID-19 Infection Chains Within Healthcare Institutions - Another Brick in the Wall Against SARS-CoV-2", Studies in health technology and informatics, vol. 290, pp. 699—703, 2022.
DOI:10.3233/SHTI220168

Abstract:
Early anticipation of COVID-19 infection chains within hospitals is of high importance for initiating suitable measures at the right time. Infection control specialists can be supported by application systems able of consolidating and analyzing heterogeneous, up-to-now non-standardized and distributed data needed for tracking COVID-19 infections and infected patients' hospital contacts. We developed a system, Co-Surv-SmICS, assisting in infection chain detection, in an open and standards-based way to ensure reusability of the system across institutions. Data is modelled in alignment to various national modelling initiatives and consensus data definitions, queried in a standardized way by the use of OpenEHR as information modelling standard and its associated model-based query language, analyzed and interactively visualized in the application. A first version has been published and will be enhanced with further features and evaluated in detail with regard to its potentials to support specialists during their work against SARS-CoV-2.
S. Stillfried, B. Freeborn, S. Windeck and P. Boor, "Update zur kooperativen autopsiebasierten Forschung in der deutschen Pathologie, Neuropathologie und Gerichtsmedizin", Pathologie (Heidelberg, Germany), vol. 43, no. Suppl 1, pp. 101—105, 2022.
DOI:10.1007/s00292-022-01117-w
Datei:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483541/

Abstract:
Hintergrund Obduktionen sind ein wichtiges Instrument zum Verständnis von Krankheiten, einschließlich COVID-19. Material und Methoden Das im April 2020 eingerichtete und gestartete Deutsche Register für COVID-19-Obduktionen (DeRegCOVID) dient als elektronisches Rückgrat des Nationalen Obduktionsnetzwerks (NATON), das Anfang 2022 im Anschluss an DEFEAT PANDEMIcs gestartet worden ist. Ergebnisse Die vernetzte, kollaborative Obduktionsforschung des NATON-Konsortiums wird durch eine beispiellose Zusammenarbeit von 138 Personen an mehr als 35 universitären und nichtuniversitären Obduktionszentren ermöglicht, durch die Daten, einschließlich Daten zu Biomaterialien aus Pathologie, Neuropathologie und Rechtsmedizin, im DeRegCOVID gesammelt sowie gewebebasierte Forschung und Methodenentwicklung betrieben werden. Aus den teilnehmenden Obduktionszentren sind inzwischen mehr als 145 Publikationen hervorgegangen, die verschiedene grundlagenwissenschaftliche und klinische Aspekte von COVID-19 beleuchten, z. B. thromboembolische Ereignisse, Organtropismus, Nachweismethoden von SARS-CoV‑2 oder die Infektiosität von SARS-CoV‑2 bei der Obduktion. Schlussfolgerungen Die teilnehmenden Zentren haben den hohen Wert der Autopsie und der aus der Autopsie gewonnenen Daten und Biomaterialien für die moderne Medizin unter Beweis gestellt. Die geplante langfristige Fortführung und Weiterentwicklung des Registers und Netzwerks und die offene und partizipative Gestaltung ermöglichen es, alle interessierten Partner miteinzubeziehen.
C. Schug, Y. Erim, F. Geiser, N. Hiebel, P. Beschoner, L. Jerg-Bretzke, C. Albus, K. Weidner, S. Steudte-Schmiedgen, A. Borho, M. Lieb and E. Morawa, "Vaccination willingness against COVID-19 among healthcare workers in Germany: Results from a University Medicine Network survey between November 2020 and January 2021", Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, vol. 65, no. 1, pp. 74—85, Jan. 2022.
DOI:10.1007/s00103-021-03418-6
Datei:pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458789/pdf/103_2021_Article_3418.pdf
C. Struwe, M. Golinski, C. Grimm, S. Dickel, K. Grummich, M. Nothacker, S. Voigt-Radloff, J. Meerpohl and O. Moerer, "Vergleich und Bewertung internationaler Leitlinien zur Behandlung schwerer Verläufe von SARS-CoV-2-Infektionen", Dtsch Arztebl Int, vol. 119, pp. 23-30, 2022.
DOI:10.3238/arztebl.m2022.0006
K. Mayer, "Pandemic Disruptions and Transnational Care Relations: Towards Closing the “Care Gap” in International Relations Theories" in In the Realm of Corona Normativities II, Gephart, W, Eds. Verlag Vitorrio Klostermann, 2022.
K. Kades, J. Scherer, M. Zenk, M. Kempf and K. Maier-Hein, "Towards Real-World Federated Learning in Medical Image Analysis Using Kaapana" in Lecture Notes in Computer Science, Springer Nature Switzerland, 2022, pp. 130—140.
DOI:10.1007/978-3-031-18523-6_13
S. Dickel, C. Grimm, M. Popp, C. Struwe, A. Sachkova, M. Golinski, C. Seeber, F. Fichtner, D. Heise, P. Kranke, W. Meissner, S. Laudi, S. Voigt-Radloff, J. Meerpohl, O. Moerer and Group On Behalf Of The German CEOsys Study, "A Nationwide Cross-Sectional Online Survey on the Treatment of COVID-19-ARDS: High Variance in Standard of Care in German ICUs", J Clin Med, vol. 10, no. 15, pp. 3363, Jul. 2021.
DOI:10.3390/jcm10153363
K. Evert, T. Dienemann, C. Brochhausen, D. Lunz, M. Lubnow, M. Ritzka and et al, "Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation", Virchows Arch, vol. 479, pp. 97-108, Jan. 2021.
DOI:https://doi.org/10.1007/s00428-020-03014-0
C. Grimm, S. Dickel, A. Sachkova, M. Popp, M. Golinksi, F. Fichtner, P. Kranke, C. Seeber, S. Laudi, S. Voigt-Radloff and O. Moerer, "Targeted Minimal Staff-to-Patient Ratios Are Unachievable - A Nationwide Survey in German ICUs During the COVID-19 Pandemic", Cureus, vol. 13, no. 6, pp. e15755, Jun. 2021.
DOI:10.7759/cureus.15755
C. Holzmann-Littig, M. C. Braunisch, P. Kranke, M. Popp, C. Seeber, F. Fichtner, B. Littig, J. Carbajo-Lozoya, C. Allwang, T. Frank, J. J. Meerpohl, B. Haller and C. Schmaderer, "COVID-19 Vaccination Acceptance and Hesitancy among Healthcare Workers in Germany", Vaccines (Basel), vol. 9, no. 7, pp. 777, Jul. 2021.
DOI:10.3390/vaccines9070777
M. Ackermann, C. Werlein, F. Länger, M. Kühnel and D. Jonigk, "COVID-19: Auswirkungen auf Lunge und Herz", Pathologe, vol. 42, pp. 164-171, Feb. 2021.
DOI:https://doi.org/10.1007/s00292-021-00918-9
M. Jansky, F. Schade, N. Rieder, D. Lohrmann, C. Gebel and others, "‘It felt like a black hole, great uncertainty, but we have to take care for our patients’–Qualitative findings on the effects of the COVID-19 pandemic on specialist palliative home care", PLOS ONE, vol. 16, no. 12, pp. e0260767, 2021.
DOI:10.1371/journal.pone.0260767
K. Schloesser, S. T. Simon, B. Pauli and others, "“Saying goodbye all alone with no close support was difficult”- Dying during the COVID-19 pandemic: an online survey among bereaved relatives about end-of-life care for patients with or without SARS-CoV2 infection", BMC Health Serv Res, vol. 21, no. 998, 2021.
DOI:10.1186/s12913-021-06987-z
C. Gebel, L. Kloppenburg, M. K. Jansky, F. Nauck, F. Schade and U. Weddin, "„Es waren Kreativität und Umdenken erforderlich.“ Auswirkungen der COVID-19 Pandemie auf die spezialisierte ambulante Palliativversorgung (SAPV). Eine bundesweite Onlinebefragung", Gesundheitswesen, 2021.
DOI:10.1055/a-1714-8336
M. Reichardt, P. Moller Jensen, V. Andersen Dahl, A. Bjorholm Dahl, M. Ackermann, H. Shah, F. Länger, C. Werlein, M. P. Kuehnel, D. Jonigk and T. Salditt, "3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography", eLife, vol. 10, pp. e71359, 2021.
DOI:10.7554/eLife.71359
Datei:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8747495/

Abstract:
For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue from patients who succumbed to Covid-19. By extending conventional histopathological examination by a third dimension, the delicate pathological changes of the vascular system of severe Covid-19 progressions can be analyzed, fully quantified and compared to other types of viral myocarditis and controls. To this end, cardiac samples with a cross-section of 3.5mm were scanned at a laboratory setup as well as at a parallel beam setup at a synchrotron radiation facility the synchrotron in a parallel beam configuration. The vascular network was segmented by a deep learning architecture suitable for 3d datasets (V-net), trained by sparse manual annotations. Pathological alterations of vessels, concerning the variation of diameters and the amount of small holes, were observed, indicative of elevated occurrence of intussusceptive angiogenesis, also confirmed by high-resolution cone beam X-ray tomography and scanning electron microscopy. Furthermore, we implemented a fully automated analysis of the tissue structure in the form of shape measures based on the structure tensor. The corresponding distributions show that the histopathology of Covid-19 differs from both influenza and typical coxsackie virus myocarditis.
M. Reichardt, P. Moller Jensen, V. Andersen Dahl and et al, "3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography", Elife, vol. 10, pp. e71359, 2021.
DOI:10.7554/eLife.71359
N. Vesper and et al, "A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its Variants", Frontiers in immunology, vol. 12, 2021.
DOI:10.3389/fimmu.2021.730766
E. N. Iftekhar, V. Priesemann, R. Balling, S. Bauer, P. Beutels, A. C. Valdez, S. Cuschieri, T. Czypionla, U. Dumpis, E. Glaab, E. Grill, C. Hanson, P. Hotulainen, P. Klimek, M. Kretzschmar, T. Krüger, J. Krutzinna, N. Low, H. Machado, C. Martins, M. McKee, S. B. Mohr, A. Nassehi, M. Perc, E. Petelos, M. Pickersgrill, B. Prainsack, J. Rocklöv, E. Schernhammer, A. Staines, E. Szczurek, S. Tsiodras, S. Van Gucht and P. Willeit, "A look into the future of the COVID-19 pandemic in Europe: an expert consultation", The Lancet Regional Health-Europe, vol. 8, pp. 100185, 2021.
DOI:10.1016/j.lanepe.2021.100185
Z. Wang, A. Cryar, O. Lemke, D. Ludwig, P. Tober-Lau and e. a. Helbig, "A multiplex protein panel assay determines disease severity and is prognostic about outcome in COVID-19 patients", medRxiv, 2021.
DOI:10.1101/2021.12.03.21267253
M. Mahoney and et al, "A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells", Proceedings of the National Academy of Sciences of the United States of America, vol. 118, 2021.
DOI:10.1073/pnas.2108728118
A. S. Peter and et al, "A pair of non-competing neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model", European journal of immunology, 2021.
DOI:10.1002/eji.202149374
A. S. Peter, E. Roth, S. R. Schulz and et al, "A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS‐CoV‐2 infection model", Eur J Immunol, 2021.
DOI:10.1002/eji.202149374
Datei:https://doi.org/10.1002/eji.202149374
G. A. Salg, M. K. Ganten, A. M. Bucher, H. G. Kenngott and others, "A reporting and analysis framework for structured evaluation of COVID-19 clinical and imaging data", NPJ Digit Med, vol. 4, no. 1, pp. 6, 2021.
W. Schuh and et al, "A surrogate cell-based SARS-CoV-2 spike blocking assay", European journal of immunology, 2021.
DOI:10.1002/eji.202149302
V. Demichev and et al, "A time-resolved proteomic and prognostic map of COVID-19", Cell Systems, 2021.
DOI:10.1016/j.cels.2021.05.005
V. Demichev, P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault, H. Whitwell, A. Röhl, A. Freiwald, L. Szyrwiel, D. Ludwig and others, "A time-resolved proteomic and prognostic map of COVID-19", Cell Syst, vol. 12, no. 8, pp. 780—794.e7, 2021.
DOI:10.1016/j.cels.2021.05.005
V. Demichev, P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault and e. a. Whitwell, "A time-resolved proteomic and prognostic map of COVID-19", Cell Syst, vol. 12, pp. 780—+, 2021.
V. Demichev, P. Tober-Lau, O. Lemke, T. Nazarenko, C. Thibeault, H. Whitwell, A. Röhl, A. Freiwald, L. Szyrwiel, D. Ludwig, E. Helbig, P. Stubbemann, L. Lippert, S. Klein, M. Mittermaier, F. Machleidt, C. V. García, C. Ruwwe-Glösenkamp, T. Lingscheid, M. S. Stegemann, P. Enghard, A. Uhrig, H. C. Müller-Redetzky, S. Hippenstiel, M. Witzenrath, N. Suttorp, M. Mülleder, L. E. Sander, P. group, M. Ralser, F. Kurth, C. Correia-Melo, S. Aulakh, N. Grüning, O. Blyuss, S. Vernardis, M. White, C. Messner, M. Joannidis, T. Sonnweber, A. Pizzini, Y. Wohlfarter, S. Sahanic, R. Hilbe, B. Schaefer, S. Wagner, L. Bosquillon de Jarcy, M. Pfeiffer, L. Jürgens, S. Denker, D. Zickler, A. Zelezniak, A. Campbell, C. Hayward, D. Porteous, R. Marioni, H. Zoller, J. Löffler-Ragg, M. Keller, I. Tancevski, J. Timms, A. Zaikin, M. Ramharter and K. Lilley, "A time-resolved proteomic and prognostic map of COVID-19", Cell Syst. 2021;12(8):780-794.e7, 2021.
L. Brümmer, S. Katzenschlager, M. Gaeddert and others, "Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis", PLOS Medicine, vol. 18, no. 8, 2021.
DOI:10.1371/journal.pmed.1003735
Datei:https://doi.org/10.1371/journal.pmed.1003735
M. L. Stanifer and S. Boulant, "Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 (BSL-3) Conditions", JoVE, no. 166, pp. e62857, 2021.
DOI:10.3791/62857
D. Mürbe, M. Kriegel, J. Lange and et al, "Aerosol emission in professional singing of classical music", Sci Rep, vol. 11, 2021.
DOI:10.1038/s41598-021-93281-x
D. Mürbe, M. Kriegel, J. Lange and et al, "Aerosol emission of adolescents voices during speaking, singing and shouting", PLoS ONE, vol. 16, no. 2, 2021.
DOI:10.1371/journal.pone.0246819
J. Schwartz, M. C. Reuters, M. Schallenburger and others, "Allgemeine Palliativversorgung in Pandemiezeiten", Onkologe, vol. 27, pp. 686-690, 2021.
DOI:10.1007/s00761-021-00970-3
J. P. Weber, J. M. Tielker, N. Kamandi and et al, "Ambulante Betreuung onkologischer Patienten in palliativer Behandlungssituation und ihrer Angehörigen in der COVID-19-Pandemie", Onkologe, vol. 27, pp. 783-789, 2021.
DOI:10.1007/s00761-021-00974-z
V. Priesemann, R. Balling, M. M. Brinkmann, S. Ciesek, T. Czypionka, I. Eckerle, G. Giordano, C. Hanson, Z. Hel, P. Hotulainen, P. Klimek, A. Nassehi, A. Peichl, M. Perc, E. Petelos, B. Prainsack and E. Szczurek, "An action plan for pan-European defence against new SARS-CoV-2 variants", The Lancet, vol. 397, no. 10273, pp. 469—470, 2021.
DOI:10.1016/S0140-6736(21)00150-1
G. Bagheri, B. Thiede, B. Hejazi and et al, "An upper bound on one-to-one exposure to infectious human respiratory particles", PNAS, vol. 118, no. 49, 2021.
DOI:10.1073/pnas.2110117118
J. Schulze, C. Mache, A. Balazs, D. Frey, D. Niemeyer and e. a. Olze, "Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses", J Infect Dis, 2021.
DOI:10.1093/infdis/jiab489
M. Renn, E. Bartok, T. Zillinger, G. Hartmann and R. Behrendt, "Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions", Pharmacology & Therapeutics, pp. 107931, 2021.
DOI:10.1016/j.pharmthera.2021.107931
D. Gagiannis, V. G. Umathum, W. Bloch, C. Rother, M. Stahl, H. M. Witte, S. Djudjaj, P. Boor and K. Steinestel, "Antemortem vs Postmortem Histopathologic and Ultrastructural Findings in Paired Transbronchial Biopsy Specimens and Lung Autopsy Samples From Three Patients With Confirmed SARS-CoV-2", Am J Clin Pathol, 2021.
DOI:10.1093/ajcp/aqab087
O. Nikolai, C. Rohardt, F. Tobian and et al, "Anterior nasal versus nasal mid-turbinate sampling for a SARS-CoV-2 antigen-detecting rapid test: does localisation or professional collection matter?", Infect Dis, vol. 53, no. 12, 2021.
DOI:10.1080/23744235.2021.1969426
Datei:https://doi.org/10.1080/23744235.2021.1969426
M. Popp, M. Stegemann, M. Riemer, M. Metzendorf, C. S. Romero, A. Mikolajewska, P. Kranke, P. Meybohm, N. Skoetz and S. Weibel, "Antibiotics for the treatment of COVID‐19", Cochrane Database of Systematic Reviews, vol. 2021, pp. CD015025, 2021.
DOI:10.1002/14651858.CD015025
K. Althaus, P. Möller, G. Uzun, A. Singh, A. Beck, M. Bettag, H. Bösmüller, M. Guthoff, F. Dorn, G. C. Petzold, H. Henkes, N. Heyne, H. Jumaa, K. Kreiser, C. Limpach, B. Luz, M. Maschke, J. Müller, J. Münch, S. Nagel, B. Pötzsch, J. Müller, C. Schlegel, A. Viardot, H. Bäzner, M. Wolf, L. Pelzl, V. Warm, W. A. Willinek, J. Steiner, N. Schneiderhan-Marra, D. Vollherbst, U. J. Sachs, F. Fend and T. Bakchoul, "Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia", Haematologica, vol. 106, no. 8, pp. 2170-2179, Aug. 2021.
DOI:10.3324/haematol.2021.279000
T. Aschman, J. Schneider, S. Greuel, J. Meinhardt, S. Streit and e. a. Goebel, "Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died", JAMA Neurol, vol. 78, pp. 948—960, 2021.
T. Aschman, J. Schneider, S. Greuel, J. Meinhardt, S. Streit, H. Goebel, I. Büttnerova, S. Elezkurtaj, F. Scheibe, J. Radke, C. Meisel, C. Drosten, H. Radbruch, F. Heppner, V. Corman and W. Stenzel, "Association Between SARS-CoV-2 Infection and Immune-Mediated Myopathy in Patients Who Have Died", JAMA Neurol, vol. 78, no. 8, pp. 948-960, Aug. 2021.
DOI:10.1001/jamaneurol.2021.2004
K. Adorjan, O. Pogarell, L. Pröbstl, M. Rüb, H. F. Wiegand, O. Tüscher, K. Lieb, E. Wassiliwizky, G. Gerlinger, A. Heinz and P. Falkai, "Auswirkungen der COVID-19-Pandemie auf die Versorgungssituation in psychiatrischen Kliniken in Deutschland", Der Nervenarzt, vol. 92, no. 6, pp. 562—570, 2021.
DOI:10.1007/s00115-021-01129-6
J. Klüpfel, R. C. Koros, K. Dehne and et al, "Automated, flow-based chemiluminescence microarray immunoassay for the rapid multiplex detection of IgG antibodies to SARS-CoV-2 in human serum and plasma (CoVRapid CL-MIA)", Anal Bioanal Chem, vol. 413, no. 22, 2021.
DOI:10.1007/s00216-021-03315-6