The NUM Study Network builds on the preliminary work of the National Pandemic Cohort Network (NAPKON), the NUM Clinical Epidemiology and Study Platform (NUKLEUS) and the NUM Data Integration Centres (NUM-DIZ). These established concepts and resulting infrastructures, organisational units and empirical values serve as the basis for a gradually growing, efficient network for the efficient implementation of clinical and clinical-epidemiological studies in Germany and will be rolled out uniformly among the participating network partners.