Publications in the NUM

Kesselmeier M, Thalheim T, Schmidt F, Peschel T, Palm J, Strübing A, Medek A, Przybilla J, Wermund AM, Maas R, Härterich S, Redeker L, Federbusch M, Steinbach D, Gewehr J, Wurlitzer M, Riedel A, Meineke F, Neumann D, Scherag A, Loeffler M, Polar_mi OBO. A distributed analysis approach for pharmacovigilance data from electronic medical records in German university hospitals: the POLAR_MI ETL Pipeline. BMC Medical Informatics and Decision Making. 2026 Jun.; 26(1):      [DOI]      [File] 

Wällisch W, Dittrich S, Purbojo A, Schöffl I, Ganslandt T, Prokosch H, Kapsner LA, Mang JM. Quality Assessment in Paediatric Cardiology: Experiences from Leveraging a Clinical Data Warehouse. Life. 2026 Jun.; 16(6):941.      [DOI]      [File] 

Fischer C, Gulden C, Quell D, Ziegler J, Hellwig D, Ganslandt T, Pukrop T, Pallaoro P. Studies in health technology and informatics. 2026 May. p. 1257—1261.      [DOI]      [File] 

Bankole J, Anywar M, Heykendorf J, Lütje K, Riemenschneider H, Rupp J, Ross P, Schreiweis B. Studies in health technology and informatics. 2026 May. p. 1332—1336.      [DOI]      [File] 

Schreiweis B, Kinast B, Ulrich H, Bronsch T, Kock-Schoppenhauer A, Bergh B. A Data-Centric Approach for Health Care and Research in a Health Knowledge Management Platform: Implementation and Requirement-Based Evaluation Study. JMIR Medical Informatics. 2026 Mar.; 14e83608.      [DOI]      [File] 

Grube S, Latus S, Moebius D, Fischer M, Raudonis V, Heinemann A, Ondruschka B, Schlaefer A. An AI Based Mobile Robot for Autonomous Ultrasound in Legal Medicine. IEEE Access. 2026 Jul.; 14108851-108865.      [DOI] 

Schultebraucks K, Gershov S, Fischer F, Wingenfeld K, Schmidt S, Steinbrecher S, Zoller T, Steinbeis F, P"utz SM, Deckert J, Scherer M, Br"ohl I, Wagner P, Appel KS, Kohls M, Jiru-Hillmann S, Nauck M, Lorenz-Depiereux B, Blaschke S, Muzalyova A, Stellbrink C, Steinmetz A, Addo MM, Dahl E, Zettler M, Hansch S, Dinkel A, Keitel V, Vehreschild MJGT, Vehreschild JJ, Paul F, Witzenrath M, Rose M, Otte C. An externally validated machine learning algorithm for predicting mental and physical health outcomes three months post-hospitalization for severe viral infection with SARS-CoV-2. Brain Behav. Immun. Health. 2026 Jul.; 54(101267):101267.

Leberzammer J, Abplanalp WT, Grikscheit K, Solomonidis EG, Glaser S, Schuhmacher B, Merten M, Jeremijev G, Wilken-Schmitz A, Korth L, John D, G"unther S, Kuenne C, Looso M, Valasarajan C, Benes V, Jung F, Niehaus V, Anton G, Stellbrink C, R"ommele C, G"opel S, Pullamsetti SS, Vehreschild J, Vehreschild M, Ciesek S, Leistner DM, Zeiher AM, Dimmeler S, Cremer S. Atherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells. Cardiovasc. Res.. 2026 Feb.; 122(1):81—97.

Allgoewer K, Lavenia A, Secco L, Schaller T, Fitzek A, Kriebel C, Azeke AT, Kondo T, Tse R, Chui P, Schmiedel S, Ondruschka B. Autopsy practices for high-consequence infectious diseases: Global guidelines, alternatives, and the BSL-4 gap. Emerging Microbes & Infections. 2026 Dec.; 15(1):2678656.      [DOI]      [File] 

Abolhassani A, Alawathurage TM, Schmidt A, Brand F, Kilarski LL, Altmann H, Dahl E, Frank S, G"opel S, Hanses F, Hellmuth JC, Herr C, Kaasch AJ, Kobbe R, Konik MJ, Pink I, R"ommele C, Rupp J, Scheer CS, Schneider MA, Stellbrink C, Stubbe HC, Tepasse P, Teufel A, Vadasz I, Vehreschild MJGT, Witzenrath M, Anton G, Br"ohl I, Herold S, Illig T, Jiru-Hillmann S, Krawitz P, Mitrov L, Philipsen A, P"utz SM, Noethen MM, Nuernberg P, Reese J, Riess O, Schreiber S, Schultze J, Steinbeis F, Vehreschild JJ, Wildberg C, Ludwig KU, Schulte EC. Genetic contribution to severe COVID-19 in adults under 60 years without major comorbidities in the German National Pandemic Cohort Network (NAPKON). Hum. Genomics. 2026 Jan.; 20(1):23.

Hoffmann W, Berg N, Schmitt J, Ihle P, Anton G, Datzmann T, Franke B, Geraedts M, Gloystein S, Hanß S, Heinrich P, Henke E, Hennings A, Heuschmann P, Illig T, Kraus M, Lang C, M"uller G, Neumann A, Ortmann S, Priya V, Reese J, Sax U, Scheithauer S, Schoffer O, Sedlmayr M, Semler SC, Swart E, Wissing F, Zeißig SR, Heyder R. Health research requires the linking of healthcare-related data. Gesundheitswesen. 2026 Apr.;

Kraus T, Napierala H, Schrimpf A, Joos S, Blaschke S, Hanses F, Vehreschild MJGT, Hamelmann E, Schmidt J, Scheer CS, R"ommele C, G"opel S, Almahfoud M, Dahl E, Hamprecht A, Kaasch AJ, Wendel J, Ole Jensen B, Tepasse P, Dashti H, Vehreschild JJ, Scherer M, Br"ohl I, Raquib S, N"urnberger C, Reese J, Appel KS, Krefting D, F"orster C, Group NS. Impact of COVID-19 vaccination on post-COVID syndrome across clinical definitions and phenotypes: a prospective multicenter cohort study. Mayo Clin. Proc.. 2026 Mar.;

Benesch Vidal ML, Haack A, Anders-Lohner S, Munzinger J, Keil LD, Albrecht JN, Borger L, Twerenbold R, Ondruschka B, Blankenberg S, Becher PM. Implementation of post-mortem examinations within a large population-based cohort: results from the Hamburg City Health Study. Clinical Research in Cardiology. 2026 Jan.; Epub ahead of print.      [DOI]      [File] 

Kuderna AK, Schneider NK, Heyder R, Schmidt G, Boor P. Infrastructure and policy reforms to facilitate collaboration in medical research. Nature Reviews Nephrology. 2026 Jun.; Epub ahead of print.      [DOI]      [File] 

Sailer B, Sari-Yavuz S, Biergans S, Verb"ucheln R, Achauer L, Rosenberger P, Hardt M, Koeppen M. Interpretable machine learning models for predicting perioperative myocardial injury in non-cardiac surgery. Eur. Heart J. Digit. Health. 2026 Jul.; 7(6):ztag093.

Sailer B, Sari-Yavuz S, Biergans S, Verb"ucheln R, Achauer L, Rosenberger P, Hardt M, Koeppen M. Interpretable machine learning models for predicting perioperative myocardial injury in non-cardiac surgery. Eur. Heart J. Digit. Health. 2026 Jul.; 7(6):ztag093.

Bartsch P, Krebs O, Augustin C, Aepfelbacher M, Rohde H, Berinson B. IS-Pro-based pathogen detection in explanted heart valves of suspected endocarditis patients. Microbiology Spectrum. 2026 Apr.; 14(4):e0398425.      [DOI]      [File] 

Bergmann J, Balandin A, Drynda S, Elke G, Klein M, Otto R, Schunk D. Kinder und Jugendliche in deutschen Notaufnahmen. Medizinische Klinik - Intensivmedizin und Notfallmedizin. 2026 Apr.; 121(3):193—200.      [DOI]      [File] 

Düsing H, Otto R, Raschke M, Walcher F, Drynda S, Waydhas C, Oeckenpöhler S. Orthopädie und Unfallchirurgie in deutschen Notaufnahmen. Die Unfallchirurgie. 2026 Feb.;      [DOI]      [File] 

Hartung TJ, Steigerwald F, Romanello A, Kodde C, Endres M, Frank S, Heuschmann P, Koehler P, Krohn S, Pape D, Schaller J, St"ocklein S, Vadasz I, Vehreschild J, Witzenrath M, Zoller T, Finke C, Group NS. Post-COVID fatigue is associated with reduced cortical thickness after hospitalization. Ann. Clin. Transl. Neurol.. 2026 Apr.; 13(4):755—766.

Heinrich F, Lücke J, Zhang S, Sabihi M, Bernreuther C, Giersch K, Allweiss L, Hartmann K, Thies E, Lange P, Matschke J, Kühl AA, Mothes R, Radbruch H, Schröder AS, Heinemann A, Dandri M, Aepfelbacher M, Huber S, Giannou A, Glatzel M, Ondruschka B, Lütgehetmann M, Krasemann S. Spatiotemporal distribution of SARS-CoV-2 vaccines and vaccine-related proteins in mice and humans. Scientific Reports. 2026 May; 16(1):15479.      [DOI]      [File] 

Bienzeisler J, Hertwig MK, Heidemeyer H, Alhaskir M, Majeed RW, Kombeiz A, Hoy W, Huening S, Goettgens F, Unterkofler J, Rademacher S, Panagiotidis D, Marewski V, Sommer A, Schirrmeister W, Walcher F, Otto R, Ehrentreich S, Beyel HH, Peeva V, Schwanen CT, Pegoraro M, Zoch-Lesniak B, Pollmanns J, Wittmar R, Stillfried DG, Röhrig R, Beckers SK, Aalst WMP, Brokmann JC. Trans-sectoral patient pathways in urgent and emergency care (TRANSPARENT study): protocol for a prospective, mixed-methods study in Germany. BMJ Open. 2026; 16(2):      [DOI] 

Mirus M, Dietze A, Tiebel O, Beyer-Westendorf J, Grottke O, Tesch F, Spieth PM, Heubner L. Viscoelastic point-of-care testing for monitoring unfractionated heparin in critically ill patients: a prospective observational study comparing ClotPro™ IN/HI-Test, aPTT and Anti-Xa activity. BMC Anesthesiol.. 2026 Mar.; 26(1):

TRANSPARENT , Group AR, Bienzeisler J, Heidemeyer H, Roehrig R, Kombeiz A, Alhaskir M, Hertwig M, Unterkofler J, Brokmann J, Otto R, Panagiotidis D, Beyel HH, Pegoraro M, Peeva V, Schwanen CT, Van Der Aalst WMP, Zoch-Lesniak B, Wittmar R, Majeed RW. A Regional Data Space for Urgent and Emergency Care in Germany. In: Giacomini, Mauro and Delgado, Jaime and Arvanitis, Theodoros N. and Andrikopoulou, Elisavet and Benis, Arriel and Balestra, Gabriella and Bellazzi, Riccardo and Gallos, Parisis and Gatta, Roberto and Giacobbe, Daniele Roberto and Giordano, Noemi and Hägglund, Maria and Lindsköld, Lars and Lhotska, Lenka and Marceglia, Sara and Parimbelli, Enea and Sacchi, Lucia and Soda, Paolo and Stoicu-Tivadar, Lăcrămioara and Veltri, Pierangelo and Vizza, Patrizia, editors. Studies in Health Technology and Informatics. IOS Press; 2026 May.      [DOI]      [File] 

Heidemeyer H, Wedek E, Majeed RW, Heitmann KU, Kombeiz A, Ehrentreich S, Drynda S, Otto R, Schirrmeister W, Röhrig R, Bienzeisler J. Extending Interoperable Emergency Department Data: Standards-Based Design and Evaluation in AKTIN. In: Giacomini, Mauro and Delgado, Jaime and Arvanitis, Theodoros N. and Andrikopoulou, Elisavet and Benis, Arriel and Balestra, Gabriella and Bellazzi, Riccardo and Gallos, Parisis and Gatta, Roberto and Giacobbe, Daniele Roberto and Giordano, Noemi and Hägglund, Maria and Lindsköld, Lars and Lhotska, Lenka and Marceglia, Sara and Parimbelli, Enea and Sacchi, Lucia and Soda, Paolo and Stoicu-Tivadar, Lăcrămioara and Veltri, Pierangelo and Vizza, Patrizia, editors. Studies in Health Technology and Informatics. IOS Press; 2026 May.      [DOI]      [File] 

Tahar K, Schirrmeister W, Ehrentreich S, Drynda S, Bienzeisler J, Walcher F, Otto R. Harmonized Data Quality Assessments on Emergency Data Across Multiple Hospitals. In: Giacomini, Mauro and Delgado, Jaime and Arvanitis, Theodoros N. and Andrikopoulou, Elisavet and Benis, Arriel and Balestra, Gabriella and Bellazzi, Riccardo and Gallos, Parisis and Gatta, Roberto and Giacobbe, Daniele Roberto and Giordano, Noemi and Hägglund, Maria and Lindsköld, Lars and Lhotska, Lenka and Marceglia, Sara and Parimbelli, Enea and Sacchi, Lucia and Soda, Paolo and Stoicu-Tivadar, Lăcrămioara and Veltri, Pierangelo and Vizza, Patrizia, editors. Studies in Health Technology and Informatics. IOS Press; 2026 May.      [DOI]      [File] 

Group AR, Kombeiz A, Wedek E, Hüning S, Heidemeyer H, Majeed RW, Röhrig R, Bienzeisler J. Implementing a Secure CI/CD Pipeline for Verifiable Trust in a Federated Health Data Network. In: Giacomini, Mauro and Delgado, Jaime and Arvanitis, Theodoros N. and Andrikopoulou, Elisavet and Benis, Arriel and Balestra, Gabriella and Bellazzi, Riccardo and Gallos, Parisis and Gatta, Roberto and Giacobbe, Daniele Roberto and Giordano, Noemi and Hägglund, Maria and Lindsköld, Lars and Lhotska, Lenka and Marceglia, Sara and Parimbelli, Enea and Sacchi, Lucia and Soda, Paolo and Stoicu-Tivadar, Lăcrămioara and Veltri, Pierangelo and Vizza, Patrizia, editors. Studies in Health Technology and Informatics. IOS Press; 2026 May.      [DOI]      [File] 

TODO

Bartenschlager C, Frey R, Freitag M, et al . Managing hospital visitor admission during Covid-19: A discrete-event simulation by the data of a German University Hospital.      [DOI] 

Klein C, Borsche M, Balck A, et al . One-year surveillance of SARS-CoV-2 transmission of the ELISA Cohort: A model for population-based monitoring of infection risk. Science Adv.

Jukic M, Dunkel A, Haller B, et al . Persistent loss of smell and taste perception in subjects with anti-SARS-CoV-2 antibodies.

Kahn M, Zellmer S, Ebigbo A, et al . Progress of the vaccination campaign among HCW in AGP in Germany.

Wulff A, Biermann P, von Landesberger T, et al . A Smart Infection Control System for COVID-19 Infections in Hospitals. In: Conference on 66. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS) 2021.     [File] 

Sobkowiak A, Scherff N, Almsick V, Schuler F, Brix TJ, Mellmann A, Schwierzeck V. Characterization of vanA-harboring plasmids supports differentiation of outbreak-related and sporadic vancomycin-resistant Enterococcus faecium isolates in a tertiary care hospital. BMC Microbiology. 2025 May 28; 25(1):337.

Kinast B, Wiedekopf J, Ulrich H, Schreiweis B. Extracting LOINC Codes from a Laboratory Information System's Index: Addressing Semantic Interoperability with Web Scraping. Stud Health Technol Inform. 2025 Apr. 24; 324234—239.

Grikscheit K, Berger A, Rabenau H, Kohmer N, Appel KS, Scherer M, Bals R, Blaschke S, Hamprecht A, Hopff SM, Krefting D, Meybohm P, Nürnberger C, Heuschmann P, Pley C, Miranda SMN, Dahl E, Jensen B, Illig T, Anton G, Vehreschild JJ, Ciesek S. Occurrence and clinical correlates of SARS-CoV-2 viremia in two German patient cohorts. Emerging Microbes & Infections. 2025 01 23; 14(1):2459137.      [DOI] 

Buchka S, Hapfelmeier A, Kirschke JS, Steuerwald V, Naumann M, Soto-Rey I, Rohr SO, Kramer F, Behrens L, Oswald E, Kümpfel T, Zimmermann H, Hoffmann VS, Hagedorn M, Albashiti F, Krumbholz M, Ziemann U, Kohlbacher O, Sailer B, Braunmüller V, Biergans S, Herr M, Ernemann U, Bürkle E, Bender B, Daul A, Ruff C, Römhild J, Wiestler B, Sepp D, Spengler H, Pallaoro P, Boeker M, Kohlmayer F, Dehmelt V, Berthele A, Mühlau M, Uibel P, Wauschkuhn J, Kuhn K, Senel M, Vardakas I, Taranu D, Kestler HA, Sollmann N, Ön BI, Bilger S, Mansmann U, Bayas A, Havla J, Kowarik MC, Tumani H, and BH. External validation of a multiple sclerosis treatment decision score using data from the ProVal-MS cohort study. Therapeutic Advances in Neurological Disorders. 2025 Nov. 21; 1817562864251391095.      [DOI] 

Graefe ASL, Rehburg F, Alkarkoukly S, Danis D, Gr"onke A, H"ubner MR, Bartschke A, Debertshäuser T, Klopfenstein SAI, Sass J, Fleck J, Rehberg M, Zsch"untzsch J, Nyoungui EF, Kalashnikova T, Murgu\'ıa-Favela L, Derfalvi B, Wright NAM, Moosa S, Ogishima S, Semler O, Wiegand S, K"uhnen P, Mungall CJ, Haendel MA, Robinson PN, Thun S, Beyan O. RareLink: scalable REDCap-based framework for rare disease interoperability linking international registries to FHIR and Phenopackets. npj Genomic Medicine. 2025 Nov. 18; 10(1):72.

Kocman SE, K"oster H, Gulden C, Kapsner LA, Engel I, Prokosch H, Mang JM. Is Research Data Trustworthy? A Quality Comparison Between FHIR, Trinetx and Clinical Data Sources. Stud Health Technol Inform. 2025 May 15; 327703—707.

Arruda Botelho M, Ata Baykara C, Burak "Unal A, Pfeifer N, Akg"un M. Privacy-preserving AUC computation in distributed machine learning with PHT-meDIC. PLOS Digital Health. 2025 Nov. 13; 4(11):e0000753.

Macedo M, Wiedekopf J, Hillmer T, Schreiweis B, Saalfeld S, Ulrich H. From text to knowledge: An end-to-end extraction pipeline for clinical information. Stud. Health Technol. Inform.. 2025 Aug. 08; 3291074—1078.

Bronsch T, Anywar M, Kinast B, Ulrich H, Macedo M, Kruse J, Behrend P, Schreiweis B. Implementation of a patient consent management at a German medical data integration center. Stud. Health Technol. Inform.. 2025 Aug. 08; 3291626—1627.

Schramm A, Raidt J, Riepenhausen S, Nygaard CMT, Tenardi-Wenge R, Qvist T, Witt P, Storck M, Olbrich H, Nielsen KG, Omran H. Limitations of PICADAR as a diagnostic predictive tool for primary ciliary dyskinesia. Front. Mol. Biosci.. 2025 Dec. 08; 12(1691758):1691758.

Lohr C, Faller J, Riedel A, Nguyen HM, Wolfien M, Hofenbitzer J, Modersohn L, Romberg J, Prasser F, Omeirat J, Wen Y, Galusch O, Hahn U, Seiferling M, Dieterich C, Kl"ugl P, Matthies F, Kind J, Boeker M, L"offler M, Meineke F. GeMTeX's DE-identification in action: Lessons learned & devil's details. In: Studies in Health Technology and Informatics. IOS Press; 2025 Sep. 03.

Neidhardt M, Bosse L, Raudonis V, Allgoewer K, Heinemann A, Ondruschka B, Schlaefer A. A Digital Twin for Robotic Post Mortem Tissue Sampling using Virtual Reality. IEEE Robotics and Automation Letters. 2025 Sep.; 10(11):11141-11147.      [DOI]      [File] 

Hoffmann T, U T, Lassen-Schmidt B, D R, LB B, T W, M K, J B, F G, G W, A P. AI-based HRCT quantification reveals DLCO and TLC as key determinants of ILD severity in connective tissue diseases.. RMD open. 2025 Oct.;      [DOI] 

D S, S S, TT M, Zhang Y, L S, D R, R B. AI-driven preclinical disease risk assessment using imaging in UK biobank.. NPJ digital medicine. 2025 Jul.;      [DOI] 

D T, LP S, N B, S G, C F, AK R, Lieb W, S S, W M, C M, M K, N W, T B, S R, K F, JJ V, O J, C M, S A, M L. Alterations of the amygdala in post-COVID olfactory dysfunction.. Scientific reports. 2025 Oct.;      [DOI] 

Schulze-Weddige S, Baumgärtner G, T O, A T, M S, D W, MP W, U H, H K, T P, J N. An Explainable AI Exploration of the Machine Learning Classification of Neoplastic Intracerebral Hemorrhage from Non-Contrast CT.. Cancers. 2025 Jul.;      [DOI] 

Lindholz M, R R, Schulze-Weddige S, Baumgärtner G, I S, A P, R S, TA A, J N, AM H, L S, L P, R H, CA H, T P. Analyzing the TotalSegmentator for facial feature removal in head CT scans.. Radiography (London, England : 1995). 2025 Jan.;      [DOI]