Publications

Impact of government pyrotechnics ban on emergency department usage rates around the turn of the years.

Ehrentreich S, Kamer N, Drynda S, Otto R, Walcher F, Lucas B.Eur J Trauma Emerg Surg. 2025 Nov 14;51(1):337. doi: 10.1007/s00068-025-03002-6.PMID: 41238806

Implementation report on pioneering federated data access for the German National Emergency Department Data Registry.

Bienzeisler J, Kombeiz A, Ehrentreich S, Otto R, Schirrmeister W, Pegoraro M, Brammen D, Puladi B, Röhrig R, W Majeed R. NPJ Digit Med. 2025 Feb 11;8(1):94. doi: 10.1038/s41746-025-01481-w. PMID: 39934366; PMCID: PMC11814142.

[Children and adolescents in German emergency departments : The most common reasons for presentation throughout the day-current insights from the AKTIN emergency department registry].

Bergmann J, Balandin A, Drynda S, Elke G, Klein M, Otto R, Schunk D. Med Klin Intensivmed Notfmed. 2025 Mar 6. doi: 10.1007/s00063-025-01254-z. Online ahead of print. PMID: 40050497

Establishing and validating syndromic surveillance of gastrointestinal infections using routine emergency department data, Germany, 2019-2023.

Baum JHJ, Dörre A, Boender TS, Heldt K, Wilking H, Drynda S, Erdmann B, Grashey R, Grupp C, Habbinga K, Hamelmann E, Heining A, Höger-Schmidt H, Kill C, Reichert F, Riße J, Schilling T; AKTIN Research Group; Schranz M. Sci Rep. 2025 Nov 3;15(1):38281. doi: 10.1038/s41598-025-13675-z. PMID: 41184312; PMCID: PMC12583625.

Embedding FHIR in Medical PDF: A Migration Path for Interoperable Documentation.

Bienzeisler J, Kombeiz A, Heidemeyer H, Hertwig M, Erdmann B, Pegoraro M, Ehrentreich S, Eder PA, Mosebach J, Rashid A, Majeed RW. Stud Health Technol Inform. 2025 Sep 3;331:186-194. doi: 10.3233/SHTI251395. PMID: 40899541.

[Can information on patients' whereabouts after an emergency department visit be used for analyses? A comparison between linked electronic health records and health claims data].

Goldhahn L, Bienzeisler J, Otto R, Swart E, Drynda S. Public Health. 2025 Nov;87(S 02):S260-S271. doi: 10.1055/a-2592-5734. Epub 2025 Sep 4. PMID: 40907545

Designing a User-Friendly Data Request Management System for a Growing Health Data Network - A Case Study in the AKTIN Registry.

Kombeiz A, Bienzeisler J, Majeed RW, Röhrig R, Aktin Research Group. Stud Health Technol Inform. 2024 Nov 22;321:69-73. doi: 10.3233/SHTI241065. PMID: 39575782.

Local Approval Processes in a Federated and Distributed Research Infrastructure - Lessons Learned from the AKTIN-Project.

Kombeiz A, Bienzeisler J, Ehrentreich S, Röhrig R, Majeed RW; Aktin Research Group. Stud Health Technol Inform. 2023 May 18;302:362-363. doi: 10.3233/SHTI230141. PMID: 37203685.

Changes in emergency department utilisation in Germany before and during different phases of the COVID-19 pandemic, using data from a national surveillance system up to June 2021.

Schranz M, Boender TS, Greiner T, Kocher T, Wagner B, Greiner F, Bienzeisler J, Diercke M, Grabenhenrich L; AKTIN-Research Group; Aigner A, Ullrich A. BMC Public Health. 2023 May 2;23(1):799. doi: 10.1186/s12889-023-15375-7. PMID: 37131165

Establishing Syndromic Surveillance of Acute Coronary Syndrome, Myocardial Infarction, and Stroke: a Registry Study Based on Routine Data From German Emergency Departments

Schranz M, Rupprecht M, Aigner A, Benning L, Schlump C, Charfeddine N, Diercke M, Grabenhenrich L, Ullrich A, Neuhauser H, Maier B, AKTIN Research Group, Hans FP, Blaschke S. JMIR Public Health and Surveillance. 20/01/2025:66218 DOI: 10.2196/66218

The Effects of Displaying the Time Targets of the Manchester Triage System to Emergency Department Personnel: Prospective Crossover Study.

Bienzeisler J, Becker G, Erdmann B,Kombeiz A, Majeed RW, Röhrig R, Greiner F, Otto R, Otto-Sobotka F, AKTIN Research Group. J Med Internet Res 2024;26:e45593 doi: 10.2196/45593

Emergency care: The digital rescue chain

Bienzeisler, Jonas; Bax, Sönke Nils; Schunk, Domagoj; Wrede, Christian; Erdmann, Bernadett; Walcher, Felix Dtsch Arztebl 2024; 121(12): A-828 / B-712

[Characteristics of older versus younger emergency patients : Analysis of over 356,000 visits from the AKTIN German emergency department data registry].

Langhoop K, Habbinga K, Greiner F, Hoffmann F, AKTIN emergency department registry. Med Klin Intensivmed Notfallmed. 2022 November 04. DOI: 10.1007/s00063-022-00968-8

Medical and cardio-vascular emergency department visits during the COVID-19 pandemic in 2020: is there a collateral damage? A retrospective routine data analysis.

Slagman A, Pigorsch M, Greiner F, Behringer W, Bernhard M, Bienzeisler J, Blaschke S, Burst V, Dechant K, Dommasch M, Ewen S, Gries A, Hans FP, Kanz KG, Klein M, Kümpers P, Napp M, Plata C, Ramshorn-Zimmer A, Risse J, Röhrig R, Somasundaram R, Schunk D, Walcher F, Walter T, Weismann D, Wolfrum S, Wörnle M, Wu YN, Möckel M. Clin Res Cardiol. 2022 Oct;111(10):1174-1182. doi: 10.1007/s00392-022-02074-3. Epub 2022 Aug 5. PMID: 35931896

Documentation standard instead of data patchwork - the AKTIN emergency admission register.

Manych, M. Z Orthop Trauma. 2022 April ;160(2):135-137. DOI: 10.1055/a-1287-0010

Establishing a Data Quality Baseline in the AKTIN Emergency Department Data Registry - A Secondary Use Perspective.

Triefenbach L, Otto R, Bienzeisler J, Kombeiz A, Ehrentreich S, Röhrig R, Majeed RW; Aktin Research Group. Stud Health Technol Inform. 2022 May 25;294:209-213. DOI: 10.3233/SHTI220439

Using Explainable Artificial Intelligence Models (ML) to Predict Suspected Diagnoses as Clinical Decision Support.

Ritter, Z., Vogel, S., Schultze, F., Pischek-Koch, K., Schirrmeister, W., Walcher, F., Röhrig, R., Kesztyüs, T., Krefting, D., Blaschke, S. Stud Health Technol Inform. 2022 May 25;294:573-574. DOI: 10.3233/SHTI220529

A Federated and Distributed Data Management Infrastructure to Enable Public Health Surveillance from Intensive Care Unit Data.

Bienzeisler, J., Triefenbach, L., Kombeiz, A., Lottes, M., Vogel, C., Grabenhenrich, L., Fischer, M., Kocher, T., Niekrenz, L., Dreher, M., Müller, C., Röhrig, R., Majeed, R.W.; AKTIN and SPoCK Research Group. Stud Health Technol Inform. 2022 May 25;294:490-494. DOI: 10.3233/SHTI220507

Length of stay as quality indicator in emergency departments: analysis of determinants in the German Emergency Department Data Registry (AKTIN registry).

Otto, R., Blaschke, S., Schirrmeister, W. et al. Intern Emerg Med. 2022 January 06;17:1199-1209. DOI: 10.1007/s11739-021-02919-1

German emergency department measures in 2018: a status quo based on the Utstein reporting standard.

Wallstab F, Greiner F, Schirrmeister W, Wehrle M, Walcher F, Wrede C, Habbinga K, Behringer W, Brammen D. BMC Emerg Med. 2022 Jan 11;22(1):5. DOI: 10.1186/s12873-021-00563-8

[Using emergency department routine data for the surveillance of suicide attempts and psychiatric emergencies].

Schlump C, Thom J, Boender TS, Wagner B, Diercke M, Kocher T, Ullrich A, Grabenhenrich L, Greiner F, Zöllner R, Mauz E, Schranz M. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022 Jan;65(1):30-39. DOI: 10.1007/s00103-021-03467-x.Epub 2021 Dec 10

Extracting real-time data from medical care to guide action in public health.

Grabenhenrich, MPH, L., Schranz, M., Boender, S. et al. Bundesgesundheitsbl. 2021 March 24;64:412-417. DOI: 10.1007/s00103-021-03300-5

Using routine emergency department data for syndromic surveillance of acute respiratory illness before and during the COVID-19 pandemic in Germany, week 10-2017 and 10-2021.

Boender, TS., Cai, W., Schranz, M., Kocher, T., Wagner, B., Ullrich, A., Buda, S., Zoellner, R., Greiner, F., Diercke, M., Grabenhenrich, L. Euro Surveill. 2022 July 07;27(27). DOI: 10.2807/1560-7917.ES.2022.27.27.2100865

The AKTIN monthly report: a plea for standardised reporting in the Emergency Departments.

Greiner, F., Erdmann, B., Thiemann, V.S. et al. Emergency Rescue Med. 2021 June 23. DOI: 10.1007/s10049-021-00910-z

The AKTIN Emergency Departments Register - continuously updated data from acute medicine : results of the register set-up and first data analyses from 15 Emergency Departments with special consideration of the Federal Joint Committee's requirements for initial assessment.

Brammen, D., Greiner, F., Kulla, M., Otto, R., Schirrmeister, W., Thun, S., Drösler, S. E., Pollmanns, J., Semler, S. C., Lefering, R., Thiemann, V. S., Majeed, R. W., Heitmann, K. U., Röhrig, R., Walcher, F., & AKTIN Emergency Department Register. Medical Clinic, Intensive Care and Emergency Medicine. 2020 December 21;117:24-33. DOI: 10.1007/s00063-020-00764-2

Evaluation of outcome relevance of quality indicators in the emergency department (ENQuIRE): study protocol for a prospective multicentre cohort study.

Drynda S, Schindler W, Slagman A, Pollmanns J, Horenkamp-Sonntag D, Schirrmeister W, Otto R, Bienzeisler J, Greiner F, Drösler S, Lefering R, Hitzek J, Möckel M, Röhrig R, Swart E, Walcher F. BMJ Open. 2020 Sep 17;10(9):e038776. DOI: 10.1136/bmjopen-2020-038776

Routine Data from Emergency Departments: Varying Documentation Standards, Billing Modalities and Data Custodians at an Identical Unit of Care.

Greiner F, Slagman A, Stallmann C, March S, Pollmanns J, Dröge P, Günster C, Rosenbusch ML, Heuer J, Drösler SE, Walcher F, Brammen D. Public Health. 2020 Mar; 82 (S 01):S72-S82. DOI: 10.1055/a-0996-8371 Epub 2019 Oct 9.

Implementation of Emergency Department Performance Benchmarking Using R and LaTeX.

Otto R, Schirrmeister W, Majeed RW et al. Stud Health Technol Inform. 2019; 267:238-246. DOI: 10.3233/SHTI190833

Requirements for sustainable standardisation and digitalisation in clinical emergency and acute medicine

Lucas, B., Brammen, D., Schirrmeister, W., Aleyt, J., Kulla, M., Röhrig, R., Walcher, F. Trauma Surgeon; 2019 March;122:243-246. DOI: 10.1007/s00113-019-0603-2

Comparing the German Emergency Department Medical Record with the US HL7 Data Elements for Emergency Department Systems.

Brammen D, Eggert P, Lucas B, Heermann-Langford L, McClay JC. Stud Health Technol Inform. 2018; 247:216-220. DOI: 10.3233/978-1-61499-852-5-216

Asynchronous Query Distribution Between Multiple i2b2 Research Data Warehouses: Li2b2-SHRINE.

Majeed RW, Stöhr MR, Thiemann VS, Röhrig R, Günther A. Stud Health Technol Inform. 2017;245:1276. DOI: 10.3233/978-1-61499-830-3-1276

Automated Report Generation for Research Data Repositories: From i2b2 to PDF.

Thiemann VS, Xu T, Röhrig R, Majeed RW. Stud Health Technol Inform. 2017;245:1289. DOI: 10.3233/978-1-61499-830-3-1289

Li2b2-Façade: Simulation of i2b2 Data Warehouse Server and Client for Interaction with Other Systems.

Majeed RW, Xu T, Stöhr MR, Röhrig R. Stud Health Technol Inform. 2017;245:1275. DOI: 10.3233/978-1-61499-830-3-1275

Secure Electronic Communications and Data Transfers in a Clinical Environment.

Xu T, Thiemann VS, Röhrig R, Brammen D, Majeed RW. Stud Health Technol Inform. 2017;245:1315. DOI: 10.3233/978-1-61499-830-3-1315

Mapping Equivalence of German Emergency Department Medical Record Concepts with SNOMED CT After Implementation with HL7 CDA.

Brammen D, Dewenter H, Heitmann K, Thiemann V, Majeed R, Walcher F, Röhrig R, Thun S. Stud Health Technol Inform. 2017;243:175-179. DOI: 10.3233/978-1-61499-808-2-175

Disseminating a Standard for Medical Records in Emergency Departments Among Different Software Vendors Using HL7 CDA.

Brammen D, Dewenter H, Thiemann V, Majeed R, Xu T, Heitmann K, Walcher K, Thun S, Röhrig R. Stud Health Technol Inform. 2017;243:132-136. DOI: 10.3233/978-1-61499-808-2-132

Standardised collection of reasons for presentation in the Emergency Departments - Implementation of coded reasons for presentation in the electronic emergency department information system of a primary care provider and their potential for health services research.

Greiner F, Brammen D, Kulla M, Walcher F, Erdmann B. Medical Clinic - Intensive Care and Emergency Medicine; 2018 March;113:115-123 [Epub ahead of print] DOI: 10.1007/s00063-017-0286-9

Lessons learned in applying the International Society for Pharmacoeconomics and Outcomes Research methodology to translating Canadian Emergency Department Information System Presenting Complaints List into German.

Brammen D, Greiner F, Dormann H. Eur J Emerg Med. 2018 Aug;25(4):295-299. [Epub ahead of print], DOI: 10.1097/MEJ.0000000000000450

Potential for capturing internationally established quality indicators through a national emergency department register - a systematic literature review

Hörster A C, Kulla M, Brammen D, Lefering R. Medical Clinic, Intensive Care Medicine and Emergency Medicine. 2018 June; 113: 409-417. DOI: 10.1007/s00063-016-0180-x

Balancing the need for big data and patient data privacy - an IT infrastructure for a decentralised emergency care research database.

Ahlbrandt J, Brammen D, Majeed R W, Lefering R, Semler S C, Thun S, Walcher F, Röhrig R. Stud Health Technol Inform. 2014;205:750-4. DOI: 10.3233/978-1-61499-432-9-750

Evaluation of quality indicators for the Emergency Departments - first application of a modified QUALIFY approach followed by an interprofessional expert discussion.

Kulla M, Goertler M, Somasundaram R, Walcher F, Greiner F, Lefering R, Wrede C, Rubak K, Hörster A, Baacke M, Erdmann B, Dormann H, Harth A, Brammen D. Emergency Rescue Med. 2016 November 24;19:646-656 DOI: 10.1007/s10049-016-0236-8

Core data set "Emergency Departments" of the DIVI - Basis for quality management and health services research in emergency departments.

Kulla M, Baacke M, Schöpke T, Walcher F, Ballaschk A, Röhrig R, Ahlbrandt J, Helm M, Lampl L, Bernhard M, Brammen D. Notfall Rettungsmed. 2014 November 20;17:671-681. DOI: 10.1007/s10049-014-1860-9

Emergency and acute medical registers in Germany.

Schirrmeister W, Wehrle M, Lefering R et al. 2019; DIVI10:148-157

From protocol to register - developments for nationwide quality management in German Emergency Departments.

Kulla M; Brammen D, Greiner F, Hörster A, Lefering R, Somasundaram R, Wrede C, Röhrig R; Erdmann B, Walcher F. 2016;DIVI 2016;7:12-19. DOI: 10.3238/DIVI.2016.0012-0020

Opportunities for the use of reference terminology within the German healthcare system - findings from the AKTIN research project

e-Health 2016

Development of a decentralised emergency admission register based on e-health standards.

Dewenter H, Thun S, Brammen D, Walcher F, Heitmann K U, Lefering R, Semler S C, Röhrig R. e-Health 2016

The DIVI emergency admission protocol becomes interoperable, E-health-compass / Intensiv- und Notfallmedizin.

Brammen D, Walcher F, Röhrig R, Heitmann K U, Majeed R W, Thun S. Health-Care-Com. 2016;-:08-11. article

AKTIN- life-saving information in a standardised guise.

Dewenter H. HL7. 2014;34. article

Health data in the national and international data space.

Waltemath, D., Beyan, O., Crameri, K. et al. FAIRe Bundesgesundheitsbl67, 710-720 (2024). doi. org/10.1007/s00103-024-03884-8

Emergency department visits by nursing home residents: analysis of routine data from an urban primary care clinic

Hoffmann, F., Habbinga, K. Med Klin Intensivmed Notfmed118, 549-555 (2023). doi. org/10.1007/s00063-022-00952-2

Digital emergency management in the network of acute and emergency care. Key issues paper of the expert council of the ZTM.

Eder, P.A., Soda, H., Kumle, B. et al.Notfall Rettungsmed(2023). doi. org/10.1007/s10049-023-01241-x

Some machine's doin' that for you* - electronic triage systems in the Emergency Departments.

Schacher, S., Kuehl, M. & Gräff, I. Notfall Rettungsmed26, 331-338 (2023). doi. org/10.1007/s10049-021-00874-0

Early warning in times of COVID-19

Evers-Wölk, M., Uhl, A. and Behrendt, S. (2023) , TATuP - Journal for Technology Assessment in Theory and Practice. DE, 32(2), pp. 24-29. doi: 10.14512/tatup.32.2.24.

General medical treatment cases in a university Emergency Departments before and after the introduction of a structured initial assessment system.

Schleef, T., Engeleit, K., Krause, O. et al.Med Klin Intensivmed Notfmed118, 382-388 (2023). doi. org/10.1007/s00063-022-00950-4

Internal hospital reporting and external benchmarking - quality management in the AKTIN emergency admission registry.

Schirrmeister W, Greiner F, Thiemann V, Majeed R, Röhrig R, Brammen D, Walcher F. TMF Registry Days 2019, 07 May 2019.

Standards and interoperability in routine documentation - insights from the development of the emergency admission register.

Schirrmeister W, Greiner F, Thiemann V, Quer O, Majeed R, Röhrig R, Brammen D, Walcher F. 20th Annual Conference of the EbM Network 2019, Berlin, 22 March 2019. DOI: 10.3205/19ebm015

Interim report AKTIN.

Brammen D. 13th Annual Conference of the German Society for Interdisciplinary Emergency and Acute Medicine 2018, Leipzig, 29 September 2018.

Challenges of health services research in acute/emergency medicine based on routine data.

Greiner F. German Congress for Orthopaedics and Trauma Surgery 2018, Berlin, 23 October - 26 October 2018

Is the Manchester triage system suitable for guiding emergency patients between the inpatient and outpatient sector?

Greiner F, Brammen D, Slagman A, Walcher F, Erdmann B. Healthcare. 2017;79(08/09):656-804. DOI: 10.1055/s-0037-1605760

Comparison of acute respiratory diseases (ARE) in the Emergency Departments of a primary care provider with data from the ARE surveillance of the Lower Saxony State Health Office between 2013 and 2016.

Greiner F, Brammen D, Erdmann B, Walcher F, Ziehm D. Public Health. 2017; 79(04): 299-374. 67th Scientific Congress of the BVÖGD and the BZÖG 2017, Munich, 03/05/05/2017. DOI: 10.1055/s-0037-1602043

Documentation and quality indicators in Emergency Departments.

Walcher F. 18th Munich Clinic Seminar 2017, Munich, 16.02-17.02.2017.

How much quality management is possible with the emergency admission register?

Hörster A. 16th Congress of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) 2016, Hamburg, 30.11-02.12.2016.

Emergency data of the specialist societies - DIVI emergency admission protocol.

Brammen D. HL7 Annual Conference 2016, Kassel, 26-28 October 2016.

Using coded presenting complaints in the symptom-based analysis of emergency department data.

Greiner F, Brammen D, Kulla M, Walcher F, Erdmann B. 20th Surgical Research Days 2016, Magdeburg, 08/09-10/09/2016. DOI: 10.1159/000448816

Data sources from ICD-10-GM for emergency admission registers.

Greiner F, Brammen D, Drösler S, Erdmann, B. AGENS Methods Workshop 2016, Munich, 03-04 March 2016 Abstract volume. - Munich, p. 29

Usability of the dataset "Emergency Departments" in a patient data management system regarding the establishment of a cda/xml Interface.

Lucas B, Schladitz P, Pliske G, Kulla M, Brammen D, Walcher F. Surgical Research Days 2016, Magdeburg, 08/09-10/09/2016.

Core data set Emergency Departments - Analyses of 15 model clinics.

Brammen D. 15th Congress of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) 2015, Leipzig, 2 - 4 December 2015.

Importing structured emergency room data from hl7:cda - lessons learned.

Thiemann V. The 2015 i2b2 European Academic User Group Meeting, 2015.

AKTIN - current status.

Brammen D. German Interdisciplinary Emergency Medicine Congress (DINK) 2015, Koblenz, 05.03.-06.03.2015.

Development of a decentralised emergency admission register in Germany.

Brammen D, Ahlbrandt J, Majeed R W, Lefering R, Semler S C, Thun S, Walcher F, Röhrig R. AGENS Methods Workshop 2015, Freiburg, 19-20 February 2015.

Semantic comparability through harmonisation and annotation of the DIVI emergency department protocol for a national emergency department register.

Brammen D, Ahlbrandt J, Majeed R W, Lefering R, Semler S C, Thun S, Walcher F, Röhrig R. TELEMED 2014 - 19th National Forum for Health Telematics and Telemedicine, Berlin, 13-14 October 2014.

IT architecture for a national emergency admission register.

Ahlbrandt J. 14th Congress of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI) 2014, Hamburg, 03 Dec - 05 Dec 2014.

An IT infrastructure for a decentralised emergency admission register.

Brammen D, Ahlbrandt J, Majeed R W, Lefering R, Semmler S C, Thun S, Walcher F, Röhrig R. 59th Annual Conference of the German Society for Medical Informatics, Biometry and Epidemiology e.V. (GMDS) 2014, Göttingen, 07-10 September 2014. DOI: 10.3205/14gmds126

IT infrastructure in the Emergency Departments and possibilities for integrating the emergency department protocol.

Brammen D. 9th Annual Conference of the German Society for Interdisciplinary Emergency and Acute Medicine (DGINA) e.V. 2014, Nuremberg, 06.11.-08.11.2014

The AKTIN project.

Brammen D. Interoperability Forum 2014, 10.03.2014, Berlin, 10.03.-11.03.2014. wiki. hl7.de/index.php?title=IF_2014-03-10