In this tutorial from the NUM Methods & Biosamples Hub (NUM-MB) Dr Anne Kaman (University Hospital Hamburg-Eppendorf) provides an introduction to the collection and analysis of Patient-Reported Outcome Measures (PROMs), using the example of health-related quality of life in children and adolescents in clinical-epidemiological studies. Using practical examples, the tutorial covers the fundamentals of PRO measurement and clearly explains key aspects of data analysis.