Publications in the NUM

Buchka S, Hapfelmeier A, Kirschke JS, Steuerwald V, Naumann M, Soto-Rey I, Rohr SO, Kramer F, Behrens L, Oswald E, Kümpfel T, Zimmermann H, Hoffmann VS, Hagedorn M, Albashiti F, Krumbholz M, Ziemann U, Kohlbacher O, Sailer B, Braunmüller V, Biergans S, Arruda Botelho Herr M, Ernemann U, Bürkle E, Bender B, Daul A, Ruff C, Römhild J, Wiestler B, Sepp D, Spengler H, Pallaoro P, Boeker M, Kohlmayer F, Dehmelt V, Berthele A, Mühlau M, Uibel P, Wauschkuhn J, Kuhn K, Senel M, Vardakas I, Taranu D, Kestler HA, Sollmann N, Irmak Ön B, Bilger S, Mansmann U, Bayas A, Havla J, Kowarik MC, Tumani H, Hemmer B. External validation of a multiple sclerosis treatment decision score using data from the ProVal-MS cohort study.. Therapeutic advances in neurological disorders. 2025;      [DOI] 

Schluessel S, Mueller B, Tausendfreund O, Rippl M, Deissler L, Martini S, Schmidmaier R, Stoecklein S, Ingrisch M, Blaschke S, Brandhorst G, Spieth P, Lehnert K, Heuschmann P, Miranda SMN, Drey M. Impact of sarcopenia and obesity on mortality in older adults with SARS-CoV-2 infection: automated deep learning body composition analysis in the NAPKON-SUEP cohort. Infection. 2025; 53(5):2111—2124.      [DOI] 

Erdekian A, Glock M, Huetter S, Rueb M, Riedinger D, Stoffers-Winterling J, Lindner S, Baum F, Tüscher O, Hölzel L, Lieb K, Adorjan K, Wiegand H. Inanspruchnahme psychiatrisch-psychotherapeutischer Versorgung in Deutschland während des ersten Jahres der COVID-19-Pandemie – Systematischer Review und Metaanalyse.. Der Nervenarzt. 2025;      [DOI]      [File] 

Höppner J, Maier C, Schlegtendal A, Hoffmann A, Petersmann A, Lücke T, Toepfner N, Brinkmann F. Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort. Scientific reports. 2025 Jan.; 15(1):2921.      [DOI]      [File] 

Valentin H, Rau H, Stahl D. Managing withdrawals and exclusions in randomized controlled trials: results from a methodological survey. BMC Anesthesiology. 2025; 25(1):148.      [DOI] 

Hartung TJ, Steigerwald F, Romanello A, Kodde C, Endres M, Frank S, Heuschmann P, Koehler P, Krohn S, Pape D, Schaller J, Stöcklein S, Vadasz I, Vehreschild J, Witzenrath M, Zoller T, Finke C. Post-COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization. Annals of clinical and translational neurology. 2025;      [DOI] 

Ziegler A, Kunzler A, Voigt-Radloff S, Schmitt J, Moerer O, Scheithauer S, Heytens H, Apfelbacher C, Meerpohl J. Priorisierung von Forschungsfragen in Gesundheitskrisen – Vorstellung eines Konzeptes, entwickelt in der COVID-19 Pandemie / Prioritization of research questions in health crises—presentation of a concept developed during the COVID-19 pandemic.. Bundesgesundheitsblatt - Gesundheitsforschung – Gesundheitsschutz. 2025;      [DOI]      [File] 

Nowak S, Wulff B, Layer YC, Theis M, Isaak A, Salam B, Block W, Kuetting D, Pieper CC, Luetkens JA, Attenberger U, Sprinkart AM. Privacy-ensuring Open-weights Large Language Models Are Competitive with Closed-weights GPT-4o in Extracting Chest Radiography Findings from Free-Text Reports. Radiology. 2025 Jan.; 314(1):e240895.      [DOI]      [File] 

Gallée L, Lisson CS, Ropinski T, Beer M, Götz M. Proto-Caps: interpretable medical image classification using prototype learning and privileged information. PeerJ. Computer science. 2025; 11e2908.      [DOI]      [File] 

Wiegand HF, Adorjan K, Stoffers-Winterling J, Scheithauer S, Schmitt J, Tuescher O, Falkai P, Lieb K. Psychische Gesundheit und psychiatrisch-psychotherapeutische Versorgung als Elemente von „pandemic and crisis preparedness“ [Mental health and mental healthcare as elements of pandemic and crisis preparedness]. Der Nervenarzt. 2025;      [DOI]      [File] 

Bujotzek MR, Akünal Ü, Denner S, Neher P, Zenk M, Frodl E, Jaiswal A, Kim M, Krekiehn NR, Nickel M, Ruppel R, Both M, Döllinger F, Opitz M, Persigehl T, Kleesiek J, Penzkofer T, Maier-Hein K, Bucher A, Braren R. Real-world federated learning in radiology: hurdles to overcome and benefits to gain.. Journal of the American Medical Informatics Association : JAMIA. 2025 Jan.;      [DOI] 

Bucher AM, Dietz J, Ehrengut C, Müller L, Schramm D, Akinina A, Drechsel M, Kloeckner R, Sieren M, Isfort P, Sähn M, Fink MA, Móré D, Melekh B, Meinel FG, Schön H, May MS, Siegler L, Münzfeld H, Ruppel R, Penzkofer T, Kim M, Balzer M, Borggrefe J, Meyer HJ, Surov A. The prognostic relevance of pleural effusion in patients with COVID-19 - A German multicenter study. Clinical imaging. 2025 Jan.; 117110303.      [DOI]      [File] 

Persigehl T, Fervers P, Bucher A, Isfort P, Maintz D, Penzkofer T, Sähn M, Vogl T, Kottlors J, Doellinger F. The RACOON viral pneumonia score for structured reporting of pre-existing, acute, and post-pneumonic findings on chest CT.. Frontiers in medicine. 2025;      [DOI] 

Bludau A, Jack A, Fischer N, Dreesman J, Drosten C, Egelkamp R, Ehlkes L, Feil F, Grundhoff A, Grundmann H, Kreuzer P, Monazahian M, Overesch I, Schmitt D, Troeger M, Reiswitz A, Weber J, Dilthey A, Hornberg C, Reuter S, Scheithauer S. Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Germany, 2023. Eurosurveillance. 2025;      [DOI]      [File] 

Liebl ME, Reisshauer A, Loudovici-Krug D, Baumbach P, Appel KS, Blaschke S, Erber J, Grewe I, Hagen M, Heim E, Pütz SM, Lehnert K, Meybohm P, Miljukov O, Milovanovic M, Miranda SM, Römmele C, Tepasse P, Vehreschild JJ, Weinert N, Weigl M, Wendel J, Lemhöfer C. Utilization of interdisciplinary in-hospital early rehabilitation in COVID-19 patients - a multicenter cohort study in the National Pandemic Cohort Network (NAPKON) in Germany. PloS one. 2025; 20(10):e0334941.      [DOI] 

Glock M, Erdekian A, Rueb M, Uhl F, Husemann R, Stoffers-Winterling J, Lindner S, Hölzel L, Lieb K, Adorjan K, Wiegand H. Utilization of mental health services during the first year of the COVID-19 pandemic - a systematic review and meta-analysis. Eur Psychiatry. 2025;      [DOI]      [File] 

Heming M, B"orsch A, Melnik S, Gmahl N, M"uller-Miny L, Dambietz C, Fisch L, Kühnel T, Brix TJ, Janssen A, Schumann E, Gross CC, Varghese J, Hahn T, Wiendl H, Meyer Zu H"orste G. Atlas of Cerebrospinal Fluid Immune Cells Across Neurological Diseases. Ann Neurol. 2024 Dec. 12; 97(4):779—790.

Gupta V, Erdal B, Ramirez C, Floca R, Genereaux B, Bryson S, Bridge C, Kleesiek J, Nensa F, Braren R, Younis K, Penzkofer T, Bucher AM, Qin MM, Bae G, Lee H, Cardoso MJ, Ourselin S, Kerfoot E, Choudhury R, White RD, Cook T, Bericat D, Lungren M, Haukioja R, Shuaib H. Current State of Community-Driven Radiological AI Deployment in Medical Imaging.. JMIR AI. 2024 Dec.;      [DOI] 

Theis M, Garajová L, Salam B, Nowak S, Block W, Attenberger UI, Kütting D, Luetkens JA, Sprinkart AM. Deep learning for opportunistic, end-to-end automated assessment of epicardial adipose tissue in pre-interventional, ECG-gated spiral computed tomography.. Insights into imaging. 2024 Dec.;      [DOI] 

Sayed M, Saba-Sadiya S, Wichtlhuber B, Dietz J, Neitzel M, Keller L, Roig G, Bucher AM. Evaluating Medical Image Segmentation Models Using Augmentation.. Tomography (Ann Arbor, Mich.). 2024 Dec.;      [DOI] 

Hoffmann AT, Kobbe R, Denz R, Maier C, Toepfner N, Timmesfeld N, Petersmann A, Giesbrecht K, Hovardovska O, Vehreschild JJ, Scherer M, Miranda SMN, Mitrov L, Friedrichs A, Caliebe A, Skipiol KE, Holzwarth S, Kaur Y, Schlegtendal A, Hojenski L, Ruß A, Vehreschild MJGT, Brinkmann F. Health and socio-demographic background of Ukrainian minors and their families in Germany - challenges for refugee medicine : A cross-sectional study from the German Network University Medicine (NUM). European journal of pediatrics. 2024 Dec.; 184(1):64.      [DOI]      [File] 

Wolf D, Payer T, Lisson CS, Lisson CG, Beer M, Götz M, Ropinski T. Less is More: Selective reduction of CT data for self-supervised pre-training of deep learning models with contrastive learning improves downstream classification performance. Computers in biology and medicine. 2024 Dec.; 183109242.      [DOI]      [File] 

Rong Z, Mai H, Ebert G, Kapoor S, Puelles VG, Czogalla J, Hu S, Su J, Prtvar D, Singh I, Schädler J, Delbridge C, Steinke H, Frenzel H, Schmidt K, Braun C, Bruch G, Ruf V, Sühs K, Nemati M, Hopfner F, Ulukaya S, Jeridi D, Mistretta D, Caliskan OS, Wettengel JM, Cherif F, Kolabas ZI, Molbay M, Horvath I, Zhao S, Krahmer N, Yildirim AÖ, Ussar S, Herms J, Huber TB, Tahirovic S, Schwarzmaier SM, Plesnila N, Höglinger G, Ondruschka B, Bechmann I, Protzer U, Elsner M, Bhatia HS, Hellal F, Erturk A. Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19. Cell Host & Microbe. 2024 Dec.; 32(12):2112-2130.      [DOI]      [File] 

Meyer H, Ehrengut C, Aghayev A, Hinnerichs M, Schramm D, Meinel FG, Borggrefe J, Surov A. Pleural and pericardial effusions as prognostic factors in patients with acute pulmonary embolism: a multicenter study. Emergency radiology. 2024 Dec.; 31(6):815-821.      [DOI]      [File] 

Schlegtendal A, Maier C, Stein J, Höpner J, Petersmann A, Drinka D, Berner R, Lücke T, Toepfner N, Brinkmann F. Post-coronavirus disease 2019-associated symptoms among children and adolescents in the SARS-CoV-2 Omicron era.. European journal of pediatrics. 2024 Dec.;      [DOI] 

Penzkofer T. Prostate MRI: what to consider when shopping for AI tools.. European radiology. 2024 Dec.;      [DOI] 

Penzkofer T. Prostate-MRI reporting should be done with the aid of AI systems: Pros.. European radiology. 2024 Dec.;      [DOI] 

Steeg K, Bohrer E, Schäfer SB, Vu VD, Scherberich J, Windfelder AG, Krombach GA. Re-identification of anonymised MRI head images with publicly available software: investigation of the current risk to patient privacy.. EClinicalMedicine. 2024 Dec.;      [DOI] 

Kottlors J, Fervers P, Froelich MF, Grunz J, Booz C, Iuga A, Maintz D, Heneweer C, Persigehl T, Große Hokamp N. The worldwide COVID-19 pandemic caused a decline in sonographic examinations - is this a continuing trend?. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 2024 Dec.;      [DOI] 

Bucher AM, Egger J, Dietz J, Strecker R, Hilbert T, Frodl E, Wenzel M, Penzkofer T, Hamm B, Chun FK, Vogl T, Kleesiek J, Beeres M. Value of MRI - T2 Mapping to Differentiate Clinically Significant Prostate Cancer.. Journal of imaging informatics in medicine. 2024 Dec.;      [DOI] 

Hoffmann T, Teichgräber U, Lassen-Schmidt B, Renz D, Brüheim LB, Krämer M, Oelzner P, Böttcher J, Güttler F, Wolf G, Pfeil A. Artificial intelligence-based quantification of pulmonary HRCT (AIqpHRCT) for the evaluation of interstitial lung disease in patients with inflammatory rheumatic diseases.. Rheumatology international. 2024 Nov.;      [DOI] 

Canalini L, Becker EG, Risch F, Bette S, Hellbrueck S, Becker J, Rippel K, Scheurig-Muenkler C, Kroencke T, Decker JA. Radiomics Feature Stability in True and Virtual Non-Contrast Reconstructions from Cardiac Photon-Counting Detector CT Datasets.. Diagnostics (Basel, Switzerland). 2024 Nov.;      [DOI] 

Erley J, Jahnke CM, Schüttler S, Molwitz I, Chen H, Meyer M, Muellerleile K, Cavus E, Lund GK, Blankenberg S, Adam G, Tahir E. Sex-specific ventricular morphology, function, and tissue characteristics in arterial hypertension: a magnetic resonance study of the Hamburg city health cohort.. European radiology. 2024 Nov.;      [DOI] 

Starck S, Sideri-Lampretsa V, Ritter JJM, Zimmer VA, Braren R, Mueller TT, Rueckert D. Using UK Biobank data to establish population-specific atlases from whole body MRI.. Communications medicine. 2024 Nov.;      [DOI] 

Kombeiz A, Bienzeisler J, Majeed RW, Röhrig R, Group AR. Designing a User-Friendly Data Request Management System for a Growing Health Data Network – A Case Study in the AKTIN Registry. In: Stoicu-Tivadar, Lăcrămioara and Benis, Arriel and Deserno, Thomas M. and Bolboacă, Sorana D. and Saranto, Kaija and Crişan-Vida, Mihaela and Gallos, Parisis and Chirila, Oana S. and Weber, Patrick and Mihalaş, George and Tamburis, Oscar, editors. Studies in Health Technology and Informatics. IOS Press; 2024 Nov..      [DOI]      [File] 

Zhou L, Pereiro MT, Li Y, Derigs M, Kuenne C, Hielscher T, Huang W, Kränzlin B, Tian G, Kobayashi K, Lu GN, Roedl K, Schmidt C, Günther S, Looso M, Huber J, Xu Y, Wiech T, Sperhake J, Wichmann D, Gröne H, Worzfeld T. Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. Science Translational Medicine. 2024 Oct.; 16(767):eadk5005.      [DOI] 

Surov A, Zimmermann S, Hinnerichs M, Meyer H, Aghayev A, Borggrefe J. Radiomics parameters of epicardial adipose tissue predict mortality in acute pulmonary embolism.. Respiratory research. 2024 Oct.;      [DOI] 

Li H, Liu H, Busch H, Grimm R, Huisman H, Tong A, Winkel D, Penzkofer T, Shabunin I, Choi MH, Yang Q, Szolar D, Shea S, Coakley F, Harisinghani M, Oguz I, Comaniciu D, Kamen A, Lou B. Deep Learning-based Unsupervised Domain Adaptation via a Unified Model for Prostate Lesion Detection Using Multisite Biparametric MRI Datasets.. Radiology. Artificial intelligence. 2024 Sep.;      [DOI] 

Iancu A, Bauer J, May MS, Prokosch H, Dörfler A, Uder M, Kapsner LA. Large-Scale Integration of DICOM Metadata into HL7-FHIR for Medical Research. Methods of information in medicine. 2024 Sep.; 63(3-04):77-84.      [DOI]      [File] 

Misailovski M, Koller D, Blaschke S, Berens M, Köster A, Strobl R, Berner R, Boor P, Eisenmann M, Stillfried S, Krefting D, Krone M, Liese J, Meybohm P, Ulrich- Merzenich G, Zenker S, Scheithauer S, Grill E. Refining the hospitalization rate: A mixed methods approach to differentiate primary COVID-19 from incidental cases. Infection Prevention in Practice. 2024 Sep.; 6(3):100371.      [DOI]      [File] 

Hoffmann T, Teichgräber U, Lassen-Schmidt B, Kroegel C, Krämer M, Förster M, Renz D, Oelzner P, Böttcher J, Franz M, Wolf G, Güttler F, Pfeil A. [Is JAK inhibition an option in the treatment of interstitial lung disease in rheumatoid arthritis?].. Zeitschrift fur Rheumatologie. 2024 Aug.;      [DOI] 

Manzke M, Iseke S, Böttcher B, Klemenz A, Weber M, Meinel FG. Development and performance evaluation of fully automated deep learning-based models for myocardial segmentation on T1 mapping MRI data.. Scientific reports. 2024 Aug.;      [DOI] 

Bucher AM, Koppold A, Kettner M, Kölzer S, Dietz J, Frodl E, Surov A, Pinto Dos Santos D, Vogl TJ, Verhoff MA, Beeres M, Lux C, Heinbuch S. Enhancing Forensic Diagnostics: Structured Reporting of Post-Mortem CT versus Autopsy for Laryngohyoid Complex Fractures in Strangulation.. Bioengineering (Basel, Switzerland). 2024 Aug.;      [DOI] 

Rothoeft T, Maier C, Talarico A, Schlegtendal A, Lange B, Petersmann A, Denz R, Timmesfeld N, Toepfner N, Vidal-Blanco E, Pfaender S, Lücke T, Brinkmann F. Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents.. Infection. 2024 Aug.;      [DOI] 

Gehrmann J, Soenarto DJ, Hidayat K, Beyer M, Quakulinski L, Alkarkoukly S, Berressem S, Gundert A, Butler M, Grönke A, Lennartz S, Persigehl T, Zander T, Beyan O. Seeing the primary tumor because of all the trees: Cancer type prediction on low-dimensional data.. Frontiers in medicine. 2024 Aug.;      [DOI] 

Shahzadi I, Zwanenburg A, Frohwein LJ, Schramm D, Meyer HJ, Hinnerichs M, Moenninghoff C, Niehoff JH, Kroeger JR, Borggrefe J, Surov A. Short-term mortality prediction in acute pulmonary embolism: Radiomics values of skeletal muscle and intramuscular adipose tissue.. Journal of cachexia, sarcopenia and muscle. 2024 Aug.;      [DOI] 

Lassen-Schmidt B, Baessler B, Gutberlet M, Berger J, Brendel JM, Bucher AM, Emrich T, Fervers P, Kottlors J, Kuhl P, May MS, Penzkofer T, Persigehl T, Renz D, Sähn M, Siegler L, Kohlmann P, Köhn A, Link F, Meine H, Thiemann MT, Hahn HK, Sieren MM. Cooperative AI training for cardiothoracic segmentation in computed tomography: An iterative multi-center annotation approach. European journal of radiology. 2024 Jul.; 176111534.      [DOI]      [File] 

Schwabenland M, Hasavci D, Frase S, Wolf K, Deigendesch N, Buescher JM, Mertz KD, Ondruschka B, Matschke J, Glatzel M, Frank S, Thimme R, Beck J, Hosp JA, Blank T, Bengsch B, Prinz M. High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains. Acta Neuropathologica. 2024 Jul.; 148(1):11.      [DOI] 

Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, Van Den Heuvel D, Belz L, Sobirova G, Zhang Z, Titova A, Navarro AM, Pekayvaz K, Lorenz M, Von Baumgarten L, Kranich J, Straub T, Popper B, Zheden V, Kaufmann WA, Guo C, Piontek G, Von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Brocker T, Walzog B, Scheiermann C, Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendorp RAJ, Iannacone M, Heinig M, Massberg S. Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis. Nature. 2024 Jul.; 631(8021):645—653.      [DOI]      [File] 

Misera L, Müller-Franzes G, Truhn D, Kather JN. Weakly Supervised Deep Learning in Radiology. Radiology. 2024 Jul.; 312(1):e232085.      [DOI]      [File]